Page last updated: 2024-12-07

rubiadin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rubiadin: highly genotoxic in Salmonella typhimurium [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

rubiadin : A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 3 and a methyl group at position 2. It has been isolated from Rubia yunnanensis. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
RubiagenusA plant genus of the family RUBIACEAE. The root is a source of red dyes (madder color and 1,2,4-trihydroxy-9,10-anthracenedione) and ANTHRAQUINONES.[MeSH]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]

Cross-References

ID SourceID
PubMed CID124062
CHEMBL ID251251
CHEBI ID69533
SCHEMBL ID1426928
MeSH IDM0196388

Synonyms (33)

Synonym
1,3-dihydroxy-2-methyl-9,10-anthraquinone
9,10-anthracenedione, 1,3-dihydroxy-2-methyl-
1,3-dihydroxy-2-methyl-anthracene-9,10-dione
117-02-2
rubiadin
ccris 4533
CHEMBL251251
chebi:69533 ,
1,3-dihydroxy-2-methylanthracene-9,10-dione
rubiadine
1,3-dihydroxy-2-methylanthraquinone
FT-0687288
unii-cy0uh3x06r
cy0uh3x06r ,
1,3-dihydroxy-2-methyl-9,10-anthracenedione
AKOS015914028
rubiadin [mi]
anthraquinone, 1,3-dihydroxy-2-methyl-
c.i. 75350
SCHEMBL1426928
AC-34383
Q-100965
A1-06841
DTXSID90151651
rubiadin, analytical standard
2-methylxanthopurpurin
1,3-dihydroxy-2-methylanthra-9,10-quinone
HY-N0444
mfcd02752095
Q15633911
CS-0008978
AS-79868
A893468

Research Excerpts

Overview

Rubiadin (Rub) is a genotoxic component of madder color. It is extracted from the root of Rubia tinctorum L.

ExcerptReferenceRelevance
"Rubiadin (Rub) is a genotoxic component of madder color (MC) that is extracted from the root of Rubia tinctorum L. "( Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats.
Ishii, Y; Mitsumoto, T; Namiki, M; Nohmi, T; Ogawa, K; Takasu, S; Takimoto, N; Umemura, T, 2023
)
2.64
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
antioxidantA substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
hepatoprotective agentAny compound that is able to prevent damage to the liver.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dihydroxyanthraquinone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID312303Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity2007Journal of natural products, Dec, Volume: 70, Issue:12
Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.
AID312305Chemoprevention index, ratio of IC50 for mouse Hepa lclc7 cells to activity against mouse quinone reductase2007Journal of natural products, Dec, Volume: 70, Issue:12
Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.
AID312304Cytotoxicity against mouse Hepa lclc7 cells2007Journal of natural products, Dec, Volume: 70, Issue:12
Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (12.50)18.2507
2000's11 (34.38)29.6817
2010's11 (34.38)24.3611
2020's6 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.21 (24.57)
Research Supply Index3.50 (2.92)
Research Growth Index4.91 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]