null
ChEBI ID: 38456
| Member | Definition | Class |
|---|---|---|
| tebufenozide | A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by tert-butyl, 3,5-dimethylbenzoyl and 4-ethylbenzoyl groups respectively. It is an insecticide used widely against caterpillars. | tebufenozide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (10.60) | 18.2507 |
| 2000's | 83 (54.97) | 29.6817 |
| 2010's | 43 (28.48) | 24.3611 |
| 2020's | 9 (5.96) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (0.65%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 154 (99.35%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 60.1658 | 6 | 6 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 10.8707 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 58.1080 | 3 | 3 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 48.5577 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 36.6248 | 6 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 39.7411 | 2 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 21.8724 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 54.4827 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 63.6169 | 3 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 38.5809 | 3 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 64.8601 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 16.9794 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 54.4827 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | IC50 | 24.0000 | 2 | 2 |
| 20-hydroxy-ecdysone receptor | Anthonomus grandis (boll weevil) | Ki | 12.5892 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Chilo suppressalis (striped riceborer) | Ki | 0.0013 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Choristoneura fumiferana (eastern spruce budworm) | Ki | 0.0005 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Leptinotarsa decemlineata (Colorado potato beetle) | Ki | 2.5119 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Locusta migratoria (migratory locust) | Ki | 100.0000 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | Ki | 22.1781 | 5 | 5 |
| 20-hydroxy-ecdysone receptor | Plodia interpunctella (Indianmeal moth) | Ki | 0.0032 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 21.5000 | 1 | 1 |
| Ecdysone receptor | Aedes aegypti (yellow fever mosquito) | Ki | 0.0251 | 1 | 1 |
| Ecdysone receptor | Chironomus tentans | Ki | 0.0100 | 1 | 1 |
| Ecdysone receptor | Drosophila melanogaster (fruit fly) | Ki | 0.2512 | 1 | 1 |
| Ecdysone receptor | Heliothis virescens (tobacco budworm) | Ki | 0.0032 | 1 | 1 |
| Ecdysone receptor | Lucilia cuprina (Australian sheep blowfly) | Ki | 0.1585 | 1 | 1 |
| Ecdysone receptor | Bemisia tabaci | Ki | 501.1870 | 1 | 1 |
| Ecdysone receptor | Myzus persicae (green peach aphid) | Ki | 125.8930 | 1 | 1 |
| Gene regulation protein | Heliothis virescens (tobacco budworm) | Ki | 0.0032 | 1 | 1 |
| Nuclear receptor RXR-l | Locusta migratoria (migratory locust) | Ki | 100.0000 | 1 | 1 |
| Protein ultraspiracle | Drosophila melanogaster (fruit fly) | Ki | 0.2512 | 1 | 1 |
| Protein ultraspiracle homolog | Choristoneura fumiferana (eastern spruce budworm) | Ki | 0.0005 | 1 | 1 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | IC50 | 24.0000 | 2 | 2 |
| Ultraspiracle | Chilo suppressalis (striped riceborer) | Ki | 0.0013 | 1 | 1 |
| Ultraspiracle | Chironomus tentans | Ki | 0.0100 | 1 | 1 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | Ki | 22.1781 | 5 | 5 |
| Ultraspiracle | Leptinotarsa decemlineata (Colorado potato beetle) | Ki | 7.5505 | 2 | 2 |
| Ultraspiracle isoform-A | Aedes aegypti (yellow fever mosquito) | Ki | 0.0251 | 1 | 1 |
| Ultraspiracle protein | Lucilia cuprina (Australian sheep blowfly) | Ki | 0.1585 | 1 | 1 |
| Ultraspiracle protein | Bemisia tabaci | Ki | 501.1870 | 1 | 1 |
| Ultraspiracle protein | Myzus persicae (green peach aphid) | Ki | 125.8930 | 1 | 1 |
| USP | Plodia interpunctella (Indianmeal moth) | Ki | 0.0032 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 20-hydroxy-ecdysone receptor | Spodoptera littoralis (African cotton leafworm) | EC50 | 0.0022 | 1 | 1 |
| Ecdysone receptor | Bombyx mori (domestic silkworm) | EC50 | 0.0012 | 2 | 2 |
| Ecdysone receptor | Drosophila melanogaster (fruit fly) | EC50 | 3.5659 | 2 | 2 |
| Protein ultraspiracle | Drosophila melanogaster (fruit fly) | EC50 | 3.5659 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C19 | Homo sapiens (human) | Km | 1.7000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Km | 6.8000 | 1 | 1 |