Page last updated: 2024-11-12

dihydroconiferyl alcohol glucoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dihydroconiferyl alcohol glucoside : A primary alcohol that is dihydroconiferyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID14427336
CHEMBL ID460029
CHEBI ID85156

Synonyms (19)

Synonym
dihydroconiferyl alcohol-4-o-beta-d-glucopyranoside
dihydroconiferyl alcohol glucoside
chebi:85156 ,
dihydroconiferin
CHEMBL460029
4-(3-hydroxypropyl)-2-methoxyphenyl beta-d-glucopyranoside
beta-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl
05864he5ob ,
17609-06-2
glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl, beta-d-
unii-05864he5ob
glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl, .beta.-d-
.beta.-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl
ncgc00385227-01_c16h24o8_beta-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl
NCGC00385227-01
Q27158365
DTXSID401316600
(2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[4-(3-hydroxypropyl)-2-methoxyphenoxy]oxane-3,4,5-triol
AKOS040735557

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
monomethoxybenzeneCompounds containing a benzene skeleton substituted with one methoxy group.
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
beta-D-glucosideAny D-glucoside in which the anomeric centre has beta-configuration.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
monolignol glucosides biosynthesis111

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347161Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347169Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347157Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1092161Antifungal activity against Alternaria mali assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
AID357036Antioxidant activity assessed as radical scavenging activity in FMLP-stimulated human PMNC up to 30 uM by chemiluminescence assay2001Journal of natural products, Jul, Volume: 64, Issue:7
Flavonoid, iridoid, and lignan glycosides from Putoria calabrica.
AID1092162Antifungal activity against Athelia rolfsii assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
AID1092163Antifungal activity against Magnaporthe grisea assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
AID1092160Antifungal activity against Ceratocystis paradoxa assessed as mycelial growth inhibition at 100 ug/disc after 2 to 4 days by disk diffusion method relative to control2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
AID1092159Cytotoxicity against Spodoptera litura cells assessed as growth inhibition at 20 mg/L after 24 hr by MTT assay relative to control2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]