Page last updated: 2024-11-12
dihydroconiferyl alcohol glucoside
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
dihydroconiferyl alcohol glucoside : A primary alcohol that is dihydroconiferyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 14427336 |
| CHEMBL ID | 460029 |
| CHEBI ID | 85156 |
Synonyms (19)
| Synonym |
|---|
| dihydroconiferyl alcohol-4-o-beta-d-glucopyranoside |
| dihydroconiferyl alcohol glucoside |
| chebi:85156 , |
| dihydroconiferin |
| CHEMBL460029 |
| 4-(3-hydroxypropyl)-2-methoxyphenyl beta-d-glucopyranoside |
| beta-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl |
| 05864he5ob , |
| 17609-06-2 |
| glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl, beta-d- |
| unii-05864he5ob |
| glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl, .beta.-d- |
| .beta.-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl |
| ncgc00385227-01_c16h24o8_beta-d-glucopyranoside, 4-(3-hydroxypropyl)-2-methoxyphenyl |
| NCGC00385227-01 |
| Q27158365 |
| DTXSID401316600 |
| (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[4-(3-hydroxypropyl)-2-methoxyphenoxy]oxane-3,4,5-triol |
| AKOS040735557 |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (1)
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (4)
| Class | Description |
|---|---|
| monomethoxybenzene | Compounds containing a benzene skeleton substituted with one methoxy group. |
| primary alcohol | A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. |
| beta-D-glucoside | Any D-glucoside in which the anomeric centre has beta-configuration. |
| monosaccharide derivative | A carbohydrate derivative that is formally obtained from a monosaccharide. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Pathways (1)
| Pathway | Proteins | Compounds |
|---|---|---|
| monolignol glucosides biosynthesis | 1 | 11 |
Bioassays (14)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1092161 | Antifungal activity against Alternaria mali assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. |
| AID357036 | Antioxidant activity assessed as radical scavenging activity in FMLP-stimulated human PMNC up to 30 uM by chemiluminescence assay | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Flavonoid, iridoid, and lignan glycosides from Putoria calabrica. |
| AID1092162 | Antifungal activity against Athelia rolfsii assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. |
| AID1092163 | Antifungal activity against Magnaporthe grisea assessed as mycelial growth inhibition at 100 ug/disk after 2 to 4 days by disk diffusion method relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. |
| AID1092160 | Antifungal activity against Ceratocystis paradoxa assessed as mycelial growth inhibition at 100 ug/disc after 2 to 4 days by disk diffusion method relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. |
| AID1092159 | Cytotoxicity against Spodoptera litura cells assessed as growth inhibition at 20 mg/L after 24 hr by MTT assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.28
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.28) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||