viscosine: a GABA-A receptor agonist with anxiolytic and anticonvulsant activities; isolated from Dodonaea viscosa; structure in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 5352032 |
| CHEMBL ID | 351607 |
| SCHEMBL ID | 1156264 |
| MeSH ID | M0063692 |
| Synonym |
|---|
| trihydroxy-flavone |
| NSC271638 , |
| 3,6-dimethoxy-5,7,4'- |
| 22697-65-0 |
| nsc-271638 |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxychromen-4-one |
| 3,6-dimethoxy kaempferol |
| CHEMBL351607 , |
| 6-methoxykaempferol 3-methyl ether |
| LMPK12112867 |
| 5,7,4'-trihydroxy-3,6-dimethoxyflavone |
| bdbm50292535 |
| 5,7-dihydroxy-2-(4-hydroxy-phenyl)-3,6-dimethoxy-chromen-4-one |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4h-chromen-4-one |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4h-1-benzopyran-4-one |
| 5v53651jor , |
| 4',5,7-trihydroxy-3,6-dimethoxyflavone |
| unii-5v53651jor |
| SCHEMBL1156264 |
| 3,6-dimethoxyapigenin |
| AKOS025287972 |
| DTXSID00177221 |
| 4',5,7-trihydroxy-3,6-dimethoxyflavone, >=90% (lc/ms-elsd) |
| FS-9486 |
| 4h-1-benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy- |
| 6-hydroxykaempferol 3,6-dimethyl ether |
| 6-methoxy-3-o-methylkaempferol |
| viscosine |
| galetin 3,6-dimethyl ether |
| flavone, 4',5,7-trihydroxy-3,6-dimethoxy- |
| 6-hydroxykaempferol 3,6-dimethylether |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 0.0400 | AID1402016; AID338975 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1402017 | Potency index, ratio of IC50 for allopurinol to IC50 for test compound for inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by UV-VIS spectrophotometric a | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254 | Xanthine oxidase inhibitory activity of natural and hemisynthetic flavonoids from Gardenia oudiepe (Rubiaceae) in vitro and molecular docking studies. |
| AID162237 | Cytotoxic dose at which 50% growth of normal cells is inhibited | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID162242 | Maximal non-toxic dose (MNTD) that shows antiviral activity. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1198221 | Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID1402016 | Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by UV-VIS spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254 | Xanthine oxidase inhibitory activity of natural and hemisynthetic flavonoids from Gardenia oudiepe (Rubiaceae) in vitro and molecular docking studies. |
| AID1198220 | Cytotoxicity against rat L6 cells assessed as viable cells at 1 uM after 72 hrs by MTT assay relative to control | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID1198226 | Antiplasmodial activity against Plasmodium falciparum FcB1/Columbia infected in human red blood cells assessed as parasite growth inhibition at 10 uM after 48 hrs by [3H]-hypoxanthine incorporation assay relative to control | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID663896 | Adipogenic activity in mouse 3T3L1 cells assessed as increase in triglyceride level after 8 days relative to control | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 ISSN: 1520-6025 | Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa. |
| AID338975 | Inhibition of cow milk xanthine oxidase | Journal of natural products, , Volume: 51, Issue:2 ISSN: 0163-3864 | Inhibition of cow's milk xanthine oxidase by flavonoids. | |
| AID162238 | Minimum drug concentration at which 99% of the polio virus is inhibited | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID235260 | Therapeutic Index measured as the ratio of CyD50(polio) / ED99(polio) values | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1198229 | Antitrypanosomal activity against Trypanosoma brucei gambiense Feo assessed as parasite growth inhibition at 10 uM after 72 hrs by fluorescence assay relative to control | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | Journal of natural products, , Volume: 51, Issue:2 ISSN: 0163-3864 | Inhibition of cow's milk xanthine oxidase by flavonoids. | |
| AID162249 | Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID162244 | The ratio of the poliovirus viral titer of the virus control (reduction factor) to the viral titer in the presence of the maximal non-toxic dose (RF MNTD) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 ISSN: 0022-2623 | 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1198225 | Leishmanicidal activity against promastigote stage of Leishmania amazonensis MHOM/BR/PH8 after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID1198219 | Cytotoxicity against rat L6 cells assessed as viable cells at 10 uM after 72 hrs by MTT assay relative to control | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID1198228 | Antitrypanosomal activity against Trypanosoma brucei gambiense Feo assessed as parasite growth inhibition at 50 uM after 72 hrs by fluorescence assay relative to control | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| AID1198222 | Antivascular activity in human EAhy926 cells assessed as concentration require to adopt rounding shape after 2 hrs by microscopic analysis | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254 | Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Muscle Contraction | 0 | 2011 | 2015 | 11.0 | high | 0 | 0 | 0 | 0 | 2 | 0 |