| Assay ID | Title | Year | Journal | Article |
|---|
| AID1447219 | Inhibition of alpha glucosidase (unknown origin) using alpha PNPG as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi. |
| AID334921 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 10000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | | | |
| AID1779095 | Antiangiogenic activity against VEGF-stimulated HUVEC cells assessed as reduction in number of sprouting tubules at 5 uM measured after 48 hrs by Matrigel assay based microscopic analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID334932 | Cytotoxicity in human HeLa cells assessed as effect on cell viability at 50 uM after 1 hr | | | |
| AID1779100 | Induction of apoptosis in VEGF-stimulated HUVEC cells assessed as increase in Cytochrome c protein expression at 5 uM measured after 48 hrs by DAPI staining based confocal microscopy | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1156795 | Retention time of the compound by chromatography | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. |
| AID1447211 | Inhibition of alpha glucosidase (unknown origin) using alpha PNPG as substrate at 0.25 mg/mL preincubated for 15 mins followed by substrate addition measured after 15 mins relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi. |
| AID334930 | Cytotoxicity in human HeLa cells assessed as decrease in cell number at 50 uM after 1 hr | | | |
| AID334928 | Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio | | | |
| AID1156796 | Binding affinity to Bcl-xL (unknown origin) | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. |
| AID334927 | Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio | | | |
| AID1779093 | Antiangiogenic activity against VEGF-induced HUVEC cells assessed as reduction in cell migration at 5 uM measured after 48 hrs by Transwell assay | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1243356 | Antioxidant activity assessed as ABTS radical scavenging activity after 6 mins | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18
| Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L. |
| AID458821 | Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase by noncompetitive inhibition assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. |
| AID1779112 | Effect on HIF-1beta expression in VEGF-stimulated HUVEC cells at 5 uM measured after 48 hrs by western blot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID334920 | Inhibition of TPA-stimulated [32P] incorporation into phospholipids in human HeLa cells at 50 uM after 1 hr | | | |
| AID334925 | Cytotoxicity against human Raji cells assessed as cell viability at 10000 molar ratio | | | |
| AID1779105 | Cytotoxicity against HUVEC cells assessed as reduction in cell vaibility at 5 uM incubated for 48 hrs by MTT assay | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID402462 | Antimicrobial activity against beta-hemolytic Streptococcus isolate 48 by paper-disk diffusion method | 1997 | Journal of natural products, Apr, Volume: 60, Issue:4
| Spinonin, a novel glycoside from Ononis spinosa subsp. leiosperma. |
| AID1779103 | Downregulation of HIF-1alpha expression in VEGF-stimulated HUVEC cells at 5 uM measured after 48 hrs by western blot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1447210 | Inhibition of alpha glucosidase (unknown origin) using alpha PNPG as substrate at 0.5 mg/mL preincubated for 15 mins followed by substrate addition measured after 15 mins relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi. |
| AID1779114 | Inhibition of ERK1/2 in VEGF-stimulated HUVEC cells assessed as reduction in phosphorylated MEK1/2 level at 5 uM incubated for 48 hrs by immunoblot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1779113 | Inhibition of MEK1/2 in VEGF-stimulated HUVEC cells assessed as reduction in phosphorylated MEK1/2 level at 5 uM incubated for 48 hrs by immunoblot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1779096 | Induction of apoptosis in VEGF-stimulated HUVEC cells at 5 uM measured after 48 hrs by AnnexinV-FITC/PI staining based flow cytometry | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID334923 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 100 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | | | |
| AID334924 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 10 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | | | |
| AID1779111 | Downregulation of HIF-1alpha expression in VEGF-stimulated HUVEC cells at 5 uM measured after 48 hrs by DAPI staining based confocal microscopy | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1447213 | Inhibition of alpha glucosidase (unknown origin) using alpha PNPG as substrate at 0.0625 mg/mL preincubated for 15 mins followed by substrate addition measured after 15 mins relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi. |
| AID1243355 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18
| Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L. |
| AID1779097 | Induction of apoptosis in VEGF-stimulated HUVEC cells assessed as mitochondrial membrane potential alteration at 5 uM measured after 48 hrs by JC-1 staining based flow cytometry | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1779107 | Induction of apoptosis in VEGF-stimulated HUVEC cells assessed as increase in cleaved caspase-9 protein expression at 5 uM measured after 48 hrs by western blot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID334922 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 1000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | | | |
| AID1243357 | Antioxidant activity assessed as reduction of Fe3+ to Fe2+ after 20 mins | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18
| Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L. |
| AID34047 | Inhibition of hamster liver aldehyde dehydrogenase ALDH-2 | 2001 | Journal of medicinal chemistry, Sep-27, Volume: 44, Issue:20
| Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. |
| AID334929 | Inhibition of EBV-early antigen activation in human Raji cells assessed as early antigen activation at 320 nM | | | |
| AID639826 | Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate at 15 uM preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase. |
| AID1204997 | Antioxidant activity of the compound assessed as inhibition of ABTS radicals after 20 mins by spectrophotometric analysis | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2
| Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata. |
| AID125225 | Inhibition of hamster liver mitochondrial monoamine oxidase MAO | 2001 | Journal of medicinal chemistry, Sep-27, Volume: 44, Issue:20
| Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. |
| AID458822 | Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase at 200 uM | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. |
| AID1875270 | Inhibition of MMP9 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10
| Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID1779102 | Induction of apoptosis in VEGF-stimulated HUVEC cells assessed as increase in cleaved caspase-3 protein expression at 5 uM measured after 48 hrs by western blot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1779101 | Induction of apoptosis in VEGF-stimulated HUVEC cells assessed as increase in Bax/Bcl2 ratio at 5 uM measured after 48 hrs by western blot analysis | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID1156800 | Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. |
| AID1156797 | Binding affinity to IL-2 (unknown origin) | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. |
| AID1779104 | Inhibition of VEGFR2 expression in VEGF-induced HUVEC cells at 5 uM incubated for 48 hrs by DAPI staining based confocal microscopy | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID334926 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio | | | |
| AID1447212 | Inhibition of alpha glucosidase (unknown origin) using alpha PNPG as substrate at 0.125 mg/mL preincubated for 15 mins followed by substrate addition measured after 15 mins relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi. |
| AID1779094 | Antiangiogenic activity against VEGF-induced HUVEC cells assessed as reduction in wound healing at 5 uM measured after 48 hrs by scratch-wound healing assay | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6
| Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |