Compounds > shizukaol B
Page last updated: 2024-11-13

shizukaol B

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

shizukaol B: from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56661508
CHEMBL ID1813267
CHEBI ID69783

Synonyms (9)

Synonym
shizukaol b
chebi:69783 ,
CHEMBL1813267
methyl (2z)-2-(dihydroxy-trimethyl-pentaoxo-[?]ylidene)propanoate
142279-40-1
Q27138125
methyl (2z)-2-[(1s,13e,18s,19s,21r,22s,23s,26s,28r,29s,30r,33r,36r)-18,30-dihydroxy-14,22,29-trimethyl-3,7,10,15,31-pentaoxo-2,6,11,16-tetraoxanonacyclo[16.15.3.125,29.01,23.04,34.019,21.022,36.026,28.033,37]heptatriaconta-4(34),13,25(37)-trien-32-ylidene
DTXSID701316928
(-)-shizukaol b
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID611909Antiviral activity against Human immunodeficiency virus 1 NL 4.3 harboring reverse transcriptase Y181C mutant pseudotyped with VSV-G envelope co-transfected with luciferase gene infected in 293T cells assessed as inhibition of HIV1 replication administere2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID1437493Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green 1 assay2017Journal of natural products, 01-27, Volume: 80, Issue:1
Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships.
AID611910Cytotoxicity against human C8166 cells by MTT assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID1537348Cytotoxicity against mouse RAW264.7 cells assessed as cellular metabolic activity at 50 uM after 48 hrs by MTT assay relative to control2019Journal of natural products, 02-22, Volume: 82, Issue:2
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
AID611907Antiviral activity against wild type Human immunodeficiency virus 1 NL 4.3 pseudotyped with VSV-G envelope co-transfected with luciferase gene infected in human 293T cells assessed as inhibition of HIV1 replication administered 15 mins prior to infection 2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID1303557Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Natural nitric oxide (NO) inhibitors from Chloranthus japonicus.
AID611911Therapeutic index, ratio of CC50 for against human C8166 cells to EC50 for HIV-12011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID664752Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Terpenoids from Chloranthus serratus and their anti-inflammatory activities.
AID611912Antiviral activity against Human immunodeficiency virus 1 assessed as inhibition of virus-induced cytopathic effects by cell based assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID1437495Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-resistant Plasmodium falciparum Dd22017Journal of natural products, 01-27, Volume: 80, Issue:1
Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships.
AID611908Antiviral activity against Human immunodeficiency virus 1 NL 4.3 harboring reverse transcriptase K103N mutant pseudotyped with VSV-G envelope co-transfected with luciferase gene infected in 293T cells assessed as inhibition of HIV1 replication administere2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
AID1537347Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method2019Journal of natural products, 02-22, Volume: 82, Issue:2
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
AID1437494Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay2017Journal of natural products, 01-27, Volume: 80, Issue:1
Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.0610azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		2.0610acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.1510organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
doxorubicin hydrochloride
[no description available]		2.1510anthracycline
sesquiterpenes
[no description available]		2.1510
n(6)-(1-iminoethyl)lysine
N(6)-acetimidoyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group		2.2110L-lysine derivative;
non-proteinogenic L-alpha-amino acid
quercetin
[no description available]		2.13107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
shizukaol f
shizukaol F: an inhibitor of HIV-1 reverse transcriptase RNase H; structure in first source		3.0440triterpenoidmetabolite
shizukaol d
shizukaol D: isolated from Chloranthusjaponicus; structure in first source		2.8530triterpenoidmetabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.1510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.1510