| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID506977 | Anticancer activity against human NCI-N417 cells xenografted in ip dosed athymic mouse assessed as tumor caspase-3 cleavage administered daily for 5 consecutive days measured after 12 hrs post last dose by immunohistochemistry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334325 | Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506554 | Binding affinity to HSP90 in human NCI-H526 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334311 | Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha at 10 uM by fluorescence polarization assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334326 | Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334367 | Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334339 | Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1653909 | Ratio of IC50 for TRAP1 (unknown origin) to IC50 for recombinant HSP90alpha (unknown origin) incubated for 24 hrs in presence of 1-FITC3 probe | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID1334336 | Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1765860 | Inhibition of Grp94 in human HeLa cells assessed as reduction in HER2 protein expression at 25 uM after 12 hrs by Western blotting analysis | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID1648023 | Competitive inhibition of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) assessed as ratio of substrate Kcat to Km at 5 uM preincubated for 0.5 hrs followed by varying levels of ATP addition and measured after 3 | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334312 | Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648021 | Competitive inhibition of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) assessed as substrate Km at 5 uM preincubated for 0.5 hrs followed by varying levels of ATP addition and measured after 3 hrs using PiColo | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1765859 | Inhibition of Grp94 in human HeLa cells assessed as reduction in cdk4 protein expression at 25 uM after 12 hrs by Western blotting analysis | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID1334369 | Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1372052 | Antibacterial activity against Escherichia coli DC2 after 24 hrs by broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1334356 | Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334313 | Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1372064 | Binding affinity to recombinant Caulobacter vibrioides cell cycle histidine kinase CckA delta 3 mutant DHp domain (190 to 562 residues) expressed in Escherichia coli assessed as change in metlting temperature at 30 uM after 2 mins by SYPRO orange dye base | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID506578 | Inhibition of HSP90-mediated proliferation of human NCI-H187 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID767752 | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from dog Grp94 after 24 hrs by fluorescence polarization assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. |
| AID506576 | Inhibition of HSP90-mediated proliferation of human NCI-N417 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334328 | Cytotoxicity against human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506579 | Inhibition of HSP90-mediated proliferation of human NCI-H209 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334331 | Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506982 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 3 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID395896 | Inhibition of Hsp90 | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Discovery and development of heat shock protein 90 inhibitors. |
| AID1765856 | Inhibition of HSP90 in human HeLa cells assessed as reduction in cdk4 protein expression at 25 uM after 12 hrs by Western blotting analysis | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID506984 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 8 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID258971 | Growth inhibition in human breast cancer MDA-MB-468 cell line using SRB | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1648022 | Competitive inhibition of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) assessed as substrate Kcat at 5 uM preincubated for 0.5 hrs followed by varying levels of ATP addition and measured after 3 hrs using PiCo | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334322 | Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506583 | Inhibition of HSP90-mediated proliferation of human SKBR3cells after 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID506985 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 12 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID506959 | Inhibition of HSP90-mediated antiapoptotic activity in human WBA cells assessed as induction of cell growth arrest at 10 after 96 hrs by propidium iodide staining-based flow cytometry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334347 | Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258968 | Growth inhibition in human breast cancer SKBr3 cell line using SRB | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID506980 | Anticancer activity against human NCI-N417 cells xenografted in athymic mouse assessed as decrease in tumor Akt activity at 75 mg/kg, ip administered daily for 5 consecutive days measured after 36 hrs post last dose by immunohistochemistry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334358 | Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334305 | Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506559 | Binding affinity to HSP90 in human NCI-H510 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334342 | Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506577 | Inhibition of HSP90-mediated proliferation of human NCI-H146 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID258970 | Inhibitory activity against Hsp90 in human breast cancer MDA-MB-468 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1334363 | Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334309 | Growth inhibition of human MCF7 cells at 10 uM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334337 | Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334335 | Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334355 | Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506558 | Binding affinity to HSP90 in human NCI-H209 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1372054 | Antibacterial activity against Caulobacter crescentus NA1000 after 24 hrs by broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1653908 | Inhibition of GRP94 (unknown origin) | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID1334360 | Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258976 | Specificity towards transformed SKBr3 cell line over normal heart tissue Hsp90 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID395900 | Inhibition of Hsp90 in human SKBR3 cells assessed as Her2 degradation | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Discovery and development of heat shock protein 90 inhibitors. |
| AID1334330 | Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506575 | Inhibition of HSP90-mediated proliferation of human NCI-H526 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334366 | Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1765850 | Inhibition of PU-H71-FITC3 binding to recombinant full length TRAP1 (unknown origin) incubated for 2 hrs by fluorescence polarization assay | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID767754 | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. |
| AID1334317 | Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648020 | Stimulation of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) up to 20 uM preincubated for 0.5 hrs followed by 2 mM ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID270492 | Displacement of cy3B-GM from Hsp90alpha | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
| Synthesis of a red-shifted fluorescence polarization probe for Hsp90. |
| AID506584 | Binding affinity to HSP90 in human NCI-H526 cells at 1 uM after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1653907 | Inhibition of TRAP1 (unknown origin) | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID258972 | Antimitotic activity in human breast cancer MDA-MB-468 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID506581 | Inhibition of HSP90-mediated proliferation of human NCI-H69 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1765852 | Inhibition of PU-H71-FITC3 binding to recombinant N-terminal Grp94 (unknown origin) incubated for 2 hrs by fluorescence polarization assay | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID1648019 | Stimulation of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) up to 20 uM preincubated for 0.5 hrs followed by 0.2 mM ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID506557 | Binding affinity to HSP90 in human NCI-H187 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1372049 | Hemolytic activity against sheep RBC at 0.5 mM after 30 mins relative to control | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1334346 | Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID339642 | Inhibition of Hsp90 in human MCF7 cells assessed as Her2 level after 24 hrs by Western blot | 2008 | Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14
| Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. |
| AID1653910 | Ratio of IC50 for GRP94 (unknown origin) to IC50 for recombinant HSP90alpha (unknown origin) incubated for 24 hrs in presence of 1-FITC3 probe | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID1206608 | Selectivity ratio of IC50 for recombinant Hsp90alpha (unknown origin) to IC50 for recombinant Grp94 (unknown origin) | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
| Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
| AID1648054 | Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability up to 3 uM measured after 24 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID506987 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 36 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1653911 | Antiproliferative activity against human HeLa cells by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID1334362 | Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334340 | Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334352 | Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648015 | Inhibition of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) preincubated for 0.5 hrs followed by ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334306 | Growth inhibition of human HFF1 cells at 10 uM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334338 | Cytotoxicity against human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334368 | Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1765858 | Inhibition of HSP90alpha in human HeLa cells assessed as increase in HSP70 protein expression at 25 uM after 12 hrs by Western blotting analysis | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID258979 | Solubility in water | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID506981 | Anticancer activity against human NCI-N417 cells xenografted in athymic mouse assessed as tumor growth inhibition at nontoxic dose administered ip daily for 5 consecutive days measured on day 20 post tumor implantation | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1372066 | Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escherichia coli at 250 uM in presence of varying levels of ATP measured every 60 secs for 2 hrs by PK/LDH enzyme | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1765851 | Inhibition of PU-H71-FITC3 binding to recombinant N-terminal HSP90alpha (unknown origin) incubated for 2 hrs by fluorescence polarization assay | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID1334357 | Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334324 | Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1372068 | Inhibition of recombinant Caulobacter vibrioides N-terminal His6-tagged DHp-catalytic domain DivJ (188 to 585 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins followed by [gamma-32P]-ATP addition after 15 mins by phosphotransfer | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1334329 | Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334327 | Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1604455 | Antiproliferative activity against human MCF7 cells | 2020 | Journal of medicinal chemistry, 03-12, Volume: 63, Issue:5
| Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. |
| AID1648057 | Cytotoxicity against human LN229 cells assessed as reduction in cell viability up to 3 uM measured after 24 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID506582 | Binding affinity to HSP90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1170900 | Reduction in oxygen consumption rate in human NCI-H1299 cells incubated for 12 hrs | 2014 | Journal of medicinal chemistry, Dec-11, Volume: 57, Issue:23
| Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90. |
| AID1334320 | Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506986 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 24 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID339641 | Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay | 2008 | Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14
| Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. |
| AID506585 | Inhibition of HSP90-mediated proliferation of human NCI-H526 cells at 1 uM after 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334359 | Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1372053 | Antibacterial activity against Bacillus subtilis YB886 after 24 hrs by broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1334348 | Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334365 | Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334354 | Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258974 | Binding affinity to Hsp90 in heart tissue | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1765854 | Selectivity index, ratio of IC50 for inhibition of Grap94 (unkown origin) to IC50 for inhibition of TRAP1 (unknown origin) | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID506958 | Inhibition of HSP90-mediated antiapoptotic activity in human SKI-AC3 cells assessed as induction of cell growth arrest at 10 after 96 hrs by propidium iodide staining-based flow cytometry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334343 | Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258967 | Inhibitory activity against Hsp90 in human breast cancer SKBr3 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1372041 | Inhibition of recombinant Salmonella typhimurium N-terminal His6-SUMO-tagged DHp-catalytic domain PhoQ (257 to 487 residues) autophosphorylation expressed in Escherichia coli BL21(DE3) at 500 uM preincubated for 10 mins followed by [gamma-32P]-ATP additio | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID767751 | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from recombinant human Trap-1 after 24 hrs by fluorescence polarization assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. |
| AID1334316 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334364 | Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506954 | Inhibition of HSP90 in chemo-resistant human H69AR cells at 100 uM after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1648056 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability up to 3 uM measured after 24 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334345 | Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648032 | Binding affinity to recombinant wild-type human TRAP1 ATP site expressed in Escherichia coli BL21 (DE3) assessed as induction of conformational change by measuring closed state population of TRAP1 at 10 uM preincubated for 30 mins followed by ATP addition | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID506979 | Anticancer activity against human NCI-N417 cells xenografted in athymic mouse assessed as decrease in tumor Akt activity at 75 mg/kg, ip administered daily for 5 consecutive days measured after 6 hrs post last dose by immunohistochemistry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334307 | Growth inhibition of human HCT116 cells at 10 uM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1206607 | Displacement of PU-FITC3 from recombinant TRAP-1 (unknown origin) after 24 hrs by fluorescence polarization assay | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
| Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
| AID506580 | Inhibition of HSP90-mediated proliferation of human NCI-H510 cells at 0.3 to 0.5 uM after 72 to 96 hrs by sulforhodamine B assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID767753 | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from recombinant HSP90beta (unknown origin) after 24 hrs by fluorescence polarization assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. |
| AID1648053 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability up to 3 uM measured after 24 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1372042 | Inhibition of recombinant Caulobacter vibrioides N-terminal His6-tagged DHp-catalytic domain DivJ (188 to 585 residues) autophosphorylation expressed in Escherichia coli BL21(DE3) at 500 uM preincubated for 10 mins followed by [gamma-32P]-ATP addition aft | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1451173 | Inhibition of FITC3-labeled PU-H71 binding to recombinant human N-terminal His6-tagged TRAP1 (60 to 561 residues) expressed in Escherichia coli BL21(DE3) after 24 hrs by fluorescence polarization assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. |
| AID1334344 | Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1206606 | Displacement of Cy3B-GM from recombinant Grp94 (unknown origin) after 24 hrs by fluorescence polarization assay | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
| Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
| AID1334349 | Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1765857 | Inhibition of HSP90 in human HeLa cells assessed as reduction in HER2 protein expression at 25 uM after 12 hrs by Western blotting analysis | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID506560 | Binding affinity to HSP90 in human NCI-H69 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID506957 | Inhibition of HSP90-mediated antiapoptotic activity in human H69AR cells assessed as induction of cell growth arrest at 10 after 96 hrs by propidium iodide staining-based flow cytometry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1653906 | Inhibition of recombinant HSP90alpha (unknown origin) incubated for 24 hrs in presence of 1-FITC3 probe by fluorescence polarization assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID506555 | Binding affinity to HSP90 in human NCI-N417 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1765853 | Selectivity index, ratio of IC50 for inhibition of HSP90alpha (unkown origin) to IC50 for inhibition of TRAP1 (unknown origin) | 2021 | ACS medicinal chemistry letters, Jul-08, Volume: 12, Issue:7
| Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. |
| AID1334319 | Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506983 | Drug level in tumor of human NCI-N417 cell-xenograft athymic mouse model at 75 mg/kg, ip administered as single dose after 6 hrs by HPLC/MS/MS analysis | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1206604 | Displacement of Cy3B-GM from recombinant Hsp90alpha (unknown origin) after 24 hrs by fluorescence polarization assay | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
| Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
| AID258975 | Specificity towards transformed SKBr3 cell line over normal lung tissue Hsp90 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1334323 | Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258969 | Inhibition of Her2 degradation in human breast cancer SKBr3 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1206605 | Displacement of Cy3B-GM from recombinant Hsp90beta (unknown origin) after 24 hrs by fluorescence polarization assay | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
| Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
| AID1334332 | Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334315 | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334314 | Cytotoxicity against human Hs 578T cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1653912 | Antiproliferative activity against human PC3 cells by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. |
| AID258977 | Cytotoxicity against normal lung fibroblast MRC5 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1372065 | Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escherichia coli in presence of varying levels of ATP measured every 60 secs for 2 hrs by PK/LDH enzyme coupled a | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID258978 | Selectivity for noraml MRC5 cell line over SKBr3 cell line | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID506556 | Binding affinity to HSP90 in human NCI-H146 cells after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334321 | Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID506978 | Anticancer activity against human NCI-N417 cells xenografted in ip dosed athymic mouse assessed as decrease in tumor Akt activity administered daily for 5 consecutive days measured after 12 hrs post last dose by immunohistochemistry | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1648033 | Binding affinity to recombinant wild-type human TRAP1 ATP site expressed in Escherichia coli BL21 (DE3) assessed as induction of conformational change by measuring closed state population of TRAP1 at 10 uM measured after 30 mins in absence of ATP by TEM a | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334341 | Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648028 | Inhibition of recombinant wild-type human TRAP1 chaperone activity expressed in Escherichia coli BL21 (DE3) at 5 uM preincubated for 30 mins followed by denatured luciferase and ATP addition by luciferase refolding assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID506955 | Inhibition of HSP90 in chemo-resistant human SKI-AC3 cells at 100 uM after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1334370 | Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1648016 | Inhibition of PU-H71-FITC binding to recombinant wild-type human TRAP1 expressed in Escherichia coli BL21 (DE3) measured after 2 hrs by fluorescence polarization assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. |
| AID1334334 | Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334310 | Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1372038 | Inhibition of recombinant Salmonella typhimurium N-terminal His6-SUMO-tagged DHp-catalytic domain PhoQ (257 to 487 residues) autophosphorylation expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins followed by [gamma-32P]-ATP addition after 3 | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
| Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. |
| AID1334353 | Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334361 | Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334350 | Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID258973 | Binding affinity to Hsp90 in lung tissue | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. |
| AID1334351 | Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334318 | Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334333 | Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1334308 | Growth inhibition of human SKBR3 cells at 10 uM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
| Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. |
| AID1451174 | Inhibition of FITC3-labeled PU-H71 binding to recombinant HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. |
| AID506956 | Inhibition of HSP90 in chemo-resistant human WBA cells at 100 uM after 24 hrs by fluorescence polarization assay | 2007 | Nature chemical biology, Aug, Volume: 3, Issue:8
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |