cudraxanthone l profile

cudraxanthone L: from the root bark of Cudrania tricuspidata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	11486277
CHEMBL ID	197916
MeSH ID	M0483815

Synonym
1,3,6,7-tetrahydroxy-2-(2-methylbut-3-en-2-yl)-5-(3-methylbut-2-enyl)xanthen-9-one
cudraxanthone l
CHEMBL197916 ,
bdbm50175013
1,3,6,7-tetrahydroxy-5-(3-methylbut-2-enyl)-2-(2-methylbut-3-en-2-yl)-9h-xanthen-9-one
2-(1,1-dimethyl-2-propenyl)-5-(3-methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9h-xanthen-9-one
135541-40-1
AKOS032948133
9h-xanthen-9-one, 2-(1,1-dimethyl-2-propenyl)-1,3,6,7-tetrahydroxy-5-(3-methyl-2-butenyl)-
1,3,6,7-tetrahydroxy-5-(3-methylbut-2-en-1-yl)-2-(2-methylbut-3-en-2-yl)-9h-xanthen-9-one
B0005-164772
FS-10313

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sterol O-acyltransferase 2	Homo sapiens (human)	IC50 (µMol)	74.4000	0.1100	3.2036	9.2000	AID276035
Sialidase	Clostridium perfringens	IC50 (µMol)	0.2280	0.0010	2.4572	9.8000	AID417656
Sialidase	Clostridium perfringens	Ki	0.3528	0.1030	1.9784	7.4100	AID417658; AID417659
Sterol O-acyltransferase 1	Homo sapiens (human)	IC50 (µMol)	68.0000	0.0250	1.7975	8.0000	AID276034
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
cholesterol metabolic process	Sterol O-acyltransferase 2	Homo sapiens (human)
macrophage derived foam cell differentiation	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol storage	Sterol O-acyltransferase 2	Homo sapiens (human)
intestinal cholesterol absorption	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol efflux	Sterol O-acyltransferase 2	Homo sapiens (human)
very-low-density lipoprotein particle assembly	Sterol O-acyltransferase 2	Homo sapiens (human)
low-density lipoprotein particle clearance	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol homeostasis	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol metabolic process	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol metabolic process	Sterol O-acyltransferase 1	Homo sapiens (human)
macrophage derived foam cell differentiation	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol storage	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol efflux	Sterol O-acyltransferase 1	Homo sapiens (human)
very-low-density lipoprotein particle assembly	Sterol O-acyltransferase 1	Homo sapiens (human)
low-density lipoprotein particle clearance	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol homeostasis	Sterol O-acyltransferase 1	Homo sapiens (human)
positive regulation of amyloid precursor protein biosynthetic process	Sterol O-acyltransferase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
fatty-acyl-CoA binding	Sterol O-acyltransferase 2	Homo sapiens (human)
sterol O-acyltransferase activity	Sterol O-acyltransferase 2	Homo sapiens (human)
protein binding	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol binding	Sterol O-acyltransferase 2	Homo sapiens (human)
acyltransferase activity	Sterol O-acyltransferase 2	Homo sapiens (human)
cholesterol O-acyltransferase activity	Sterol O-acyltransferase 2	Homo sapiens (human)
fatty-acyl-CoA binding	Sterol O-acyltransferase 1	Homo sapiens (human)
sterol O-acyltransferase activity	Sterol O-acyltransferase 1	Homo sapiens (human)
protein binding	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol binding	Sterol O-acyltransferase 1	Homo sapiens (human)
cholesterol O-acyltransferase activity	Sterol O-acyltransferase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endoplasmic reticulum	Sterol O-acyltransferase 2	Homo sapiens (human)
endoplasmic reticulum membrane	Sterol O-acyltransferase 2	Homo sapiens (human)
brush border	Sterol O-acyltransferase 2	Homo sapiens (human)
endoplasmic reticulum membrane	Sterol O-acyltransferase 2	Homo sapiens (human)
endoplasmic reticulum	Sterol O-acyltransferase 1	Homo sapiens (human)
endoplasmic reticulum membrane	Sterol O-acyltransferase 1	Homo sapiens (human)
membrane	Sterol O-acyltransferase 1	Homo sapiens (human)
endoplasmic reticulum membrane	Sterol O-acyltransferase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (23)

Assay ID	Title	Year	Journal	Article
AID1688692	Inhibition of jack bean alpha-mannosidase at 1 mM using PNPG as substrate incubated for 10 mins by spectrophotometric method	2020	European journal of medicinal chemistry, Feb-15, Volume: 188	Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
AID257312	Cytotoxicity against human cancer A549 cell line by MTT assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID1688690	Inhibition of bovine kidney alpha-fucosidase at 1 mM using PNPG as substrate incubated for 10 mins by spectrophotometric method	2020	European journal of medicinal chemistry, Feb-15, Volume: 188	Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
AID257309	Cytotoxicity against human cancer HL60 cell line by MTT assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID276035	Inhibition of human ACAT2 expressed in Hi5 cells	2006	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21	Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
AID310609	Inhibition of bakers yeast alpha-glucosidase by spectrophotometry	2007	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23	Xanthones from Cudrania tricuspidata displaying potent alpha-glucosidase inhibition.
AID257308	Cytotoxicity against human cancer HT29 cell line by MTT assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID417656	Inhibition of Clostridium perfringens neuraminidase by fluorimetry	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.
AID417659	Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plot	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.
AID276034	Inhibition of human ACAT1 expressed in Hi5 cells	2006	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21	Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
AID257311	Cytotoxicity against human cancer AGS cell line by MTT assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID257306	Superoxide radical scavenging activity of Cudriana tricuspidata extracts	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID257313	DPPH radical scavenging activity of Cudriana tricuspidata extracts	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID292582	Inhibition at monoamine oxidase in mouse brain	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Prenylated xanthones from the root bark of Cudrania tricuspidata.
AID1177572	Neuroprotective activity against 6-hydroxydopamine-induced human SH-SY5Y cell death after 24 hrs by MTT assay	2014	Journal of natural products, Aug-22, Volume: 77, Issue:8	Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata.
AID276033	Antioxidant activity against human plasma LDL oxidation by TBARS assay	2006	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21	Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
AID378560	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	2005	Journal of natural products, Mar, Volume: 68, Issue:3	Cytotoxic xanthones from Cudrania tricuspidata.
AID378559	Cytotoxicity against human A549 cells after 48 hrs by SRB assay	2005	Journal of natural products, Mar, Volume: 68, Issue:3	Cytotoxic xanthones from Cudrania tricuspidata.
AID417658	Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetry	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.
AID1688687	Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric method	2020	European journal of medicinal chemistry, Feb-15, Volume: 188	Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
AID257310	Cytotoxicity against human cancer SKOV3 cell line by MTT assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID257314	Cytotoxic activity in HL60 by DNA fragmentation assay	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
AID257307	Hydroxyl radical scavenging activity of Cudriana tricuspidata extracts	2005	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24	Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (66.67)	29.6817
2010's	1 (11.11)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.25	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
probucol Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).. probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.	2.03	1	dithioketal; polyphenol	anti-inflammatory drug; anticholesteremic drug; antilipemic drug; antioxidant; cardiovascular drug
rhein [no description available]	2.25	1	dihydroxyanthraquinone
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.25	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
4-chromone 4-chromone: structure given in first source. chromone : The simplest member of the class of chromones that is 4H-chromene with an oxo group at position 4.	2.25	1	chromones; enone
physcione physcione: structure. physcion : A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.	2.25	1	dihydroxyanthraquinone	anti-inflammatory agent; antibacterial agent; antifungal agent; antineoplastic agent; apoptosis inducer; hepatoprotective agent; metabolite
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.02	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.02	1	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
acarbose [no description available]	2.25	1	tetrasaccharide derivative	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; geroprotector; hypoglycemic agent
1,4-dideoxy-1,4-imino-d-arabinitol [no description available]	2.25	1
quercetin [no description available]	2.05	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.05	1	trihydroxyflavone	antineoplastic agent; metabolite
genistein [no description available]	2.25	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
3-hydroxyblancoxanthone 3-hydroxyblancoxanthone: from the root of Calophyllum blancoi; structure in first source	2.51	2	pyranoxanthones
mangiferin shamimin: isolated from the leaves of Bombax ceiba; structure in first source	2.05	1	C-glycosyl compound; xanthones	anti-inflammatory agent; antioxidant; hypoglycemic agent; plant metabolite
norathyriol norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source. norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.	2.25	1	polyphenol; xanthones	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor; plant metabolite
Cudraflavone A [no description available]	2.03	1	extended flavonoid
muromonab-cd3 cudraflavone B: antiproliferative from Cudrania tricuspidata. cudraflavone B : An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.	2.44	2	extended flavonoid; pyranochromane; trihydroxyflavone	anti-inflammatory agent; plant metabolite
butylidenephthalide butylidenephthalide: structure in first source. (Z)-3-butylidenephthalide : A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.	2.25	1	isobenzofuranone
macluraxanthone b macluraxanthone B: from the plant Maclura tinctoria; structure in first source. macluraxanthone B : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7, a dimethylallyl group at position 2 and a prenyl group at position 4. Isolated from Maclura tinctoria and Cudrania tricuspidata, it exhibits anti-HIV and antineoplastic activity.	2.94	4	phenols; xanthones	anti-HIV agent; antineoplastic agent; metabolite
oleoylanilide oleoylanilide: alters lipid metabolism of lung & adipose tissue; do not confuse with oleoanilide; RN given refers to (Z)-isomer. oleylanilide : The fatty amide resulting from the formal condensation of oleic acid and aniline.	2.03	1	anilide; fatty amide
broussochalcone a broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source	2.25	1
casuarine casuarine: structure in first source; do not confuse with tannin casuariin	2.25	1
papyriflavonol a papyriflavonol A: isolated from Broussonetia papyrifera; structure in first source. papyriflavonol A : A pentahydroxyflavone that is flavone substituted with hydroxy groups at positions 3, 5, 7, 3' and 4' and prenyl groups at positions 6 and 5'. Isolated from Broussonetia papyrifera, it exhibits inhibitory activity against phospholipase A2 and tyrosinase.	2.25	1	3'-hydroxyflavonoid; flavonols; pentahydroxyflavone	EC 1.14.18.1 (tyrosinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; metabolite
2,3,6,8-tetrahydroxy-1-(3-methylbut-2-enyl)-5-(2-methylbut-3-en-2-yl)-9h-xanthen-9-one 2,3,6,8-tetrahydroxy-1-(3-methylbut-2-enyl)-5-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one: from the root bark of Cudrania tricuspidata; structure in first source. cudratricusxanthone A : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.	3.13	5	polyphenol; xanthones	anti-inflammatory agent; antineoplastic agent; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; metabolite
cudraflavanone a cudraflavanone A: antineoplastic from Cudrania tricuspidata; structure in first source	2.44	2

Condition	Relationship Strength	Studies
Atherogenesis [description not available]	2.03	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.03	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.1	1
Autoimmune Diabetes [description not available]	2.25	1
Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	2.25	1
Cancer of Stomach [description not available]	2.31	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.31	1

cudraxanthone l

Description

Cross-References

Synonyms (12)

Protein Targets (3)

Inhibition Measurements

Biological Processes (9)

Molecular Functions (6)

Ceullar Components (4)

Bioassays (23)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.21

Study Types

cudraxanthone l

Description

Cross-References

Synonyms (12)

Protein Targets (3)

Inhibition Measurements

Biological Processes (9)

Molecular Functions (6)

Ceullar Components (4)

Bioassays (23)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.21

Study Types

Related Drugs (26)

Related Conditions (7)