Assay ID | Title | Year | Journal | Article |
AID1867009 | Inhibition of human recombinant BRD4-BD2 expressed in Escherichia coli using C-Terminal-biotinylated histone H4 peptide as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by microplate reader method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7
| Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development. |
AID658255 | Cytotoxicity against human Huh7.5.1 cells by MTT assay | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. |
AID704067 | Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate at 1 uM incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704077 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID1167963 | Inhibition of mushroom tyrosinase | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase. |
AID704055 | Inhibition of Thermus aquaticus DNA polymerase using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate after 15 mins by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704069 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate at 1 uM incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704065 | Selectivity ratio of IC50 for tetrahymena telomerase to IC50 for telomerase in human HeLa cells by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704068 | Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID281992 | Inhibition of T3 RNA polymerase up to 2 uM | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Catecholic flavonoids acting as telomerase inhibitors. |
AID704076 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704058 | Mixed type inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID502292 | Antioxidant activity assessed as DDPH radical scavenging activity | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Relationships between structures of hydroxyflavones and their antioxidative effects. |
AID281990 | Inhibition of telomerase from A431 lysate at 1 uM by PCR-based cell-free TRAP assay | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Catecholic flavonoids acting as telomerase inhibitors. |
AID281989 | Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Catecholic flavonoids acting as telomerase inhibitors. |
AID704060 | Noncompetitive inhibition of telomerase in human HeLa cells using dNTP as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID298693 | Inhibition of CDK2 | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
| 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. |
AID704064 | Mixed type inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID1867010 | Antiproliferative activity against human MV4-11 cells by CCK-8 assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7
| Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development. |
AID1433314 | Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repeat amplification protocol assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Targeting telomerase with radiolabeled inhibitors. |
AID704070 | Binding affinity to Stenotrophomonas sp. TSG4 5'-(GGGATT)3GGGTT-3' DNA assessed as G-quadruplex stabilization at 2 uM by thermal melt analysis | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID281991 | Inhibition of telomerase in intact A431 cells at 1 uM | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Catecholic flavonoids acting as telomerase inhibitors. |
AID704075 | Inhibition of telomerase in human HEK293 cells by flashplate assay | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID704056 | Mixed type inhibition of tetrahymena telomerase using dNTP as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
AID658253 | Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |