Target type: molecularfunction
Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]
D-sorbitol dehydrogenase (acceptor) activity catalyzes the oxidation of D-sorbitol to D-fructose, using an electron acceptor other than NAD+ or NADP+. This enzyme is involved in the sorbitol pathway, which is a secondary pathway for glucose metabolism. In this pathway, glucose is first reduced to sorbitol by aldose reductase. Sorbitol can then be oxidized to fructose by sorbitol dehydrogenase. The sorbitol pathway is important in tissues such as the lens of the eye, where glucose is readily taken up but cannot be efficiently metabolized by glycolysis. The sorbitol pathway can also contribute to the development of diabetic complications, such as diabetic retinopathy and neuropathy. The electron acceptor used by D-sorbitol dehydrogenase (acceptor) activity varies depending on the organism and the specific enzyme. In some cases, the enzyme may use molecular oxygen as the electron acceptor, while in other cases, it may use other electron acceptors such as cytochrome c.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sorbitol dehydrogenase | A sorbitol dehydrogenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00796] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| coumarin | 2H-chromen-2-one: coumarin derivative | coumarins | fluorescent dye; human metabolite; plant metabolite |
| herniarin | herniarin : A member of the class of coumarins that is coumarin substituted by a methoxy group at position 7. herniarin: methoxy analog of umbelliferone; structure | coumarins | fluorochrome |
| 3-hydroxy-1-benzopyran-2-one | 3-hydroxycoumarin: Photoprotective from sea urchin gametes and embryonic cells; structure in first source hydroxycoumarin : Any coumarin carrying at least one hydroxy substituent. | hydroxycoumarin | |
| isoscopoletin | isoscopoletin : A hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. | aromatic ether; hydroxycoumarin | plant metabolite |
| cp-166,572 | |||
| epalrestat | epalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy. | monocarboxylic acid; thiazolidines | EC 1.1.1.21 (aldehyde reductase) inhibitor |
| quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
| scopoletin | hydroxycoumarin | plant growth regulator; plant metabolite | |
| hymecromone | Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID. | hydroxycoumarin | antineoplastic agent; hyaluronic acid synthesis inhibitor |
| esculetin | esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. esculetin: used in filters for absorption of ultraviolet light; structure | hydroxycoumarin | antioxidant; plant metabolite; ultraviolet filter |
| 7-hydroxycoumarin | 7-oxycoumarin: derivatives have anti-oxidant properties umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. | hydroxycoumarin | fluorescent probe; food component; plant metabolite |
| 4-methylesculetin | 4-methylesculetin: has antiinflammatory activity 6,7-dihydroxy-4-methylcoumarin : A hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. | hydroxycoumarin | anti-inflammatory agent; antioxidant; hyaluronan synthesis inhibitor |
| 7-hydroxycoumarin-4-acetic acid | 7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source | ||
| 4-hydroxycoumarin | 2-hydroxychromone: structure | hydroxycoumarin |