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naphthols
Any hydroxynaphthalene derivative that has a single hydroxy substituent.
ChEBI ID: 25392
Members (28)
| Member | Definition | Role |
|---|---|---|
| (s)-binol | (S)-(-)-1,1'-Bi-2-naphthol | |
| 1-[[(1-methyl-2-benzimidazolyl)amino]methyl]-2-naphthalenol | 1-[[(1-methyl-2-benzimidazolyl)amino]methyl]-2-naphthalenol | |
| 1-hydroxy-2-naphthoic acid | A naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. | 1-hydroxy-2-naphthoic acid |
| 1-nitroso-2-naphthol | 1-Nitroso-2-naphthol | |
| 2-[2-hydroxy-6,7-dimethoxy-4-(4-morpholinyl)-1-naphthalenyl]-N-phenylacetamide | 2-[2-hydroxy-6,7-dimethoxy-4-(4-morpholinyl)-1-naphthalenyl]-N-phenylacetamide | |
| 2-hydroxy-1-naphthaldehyde | A member of the class of naphthaldehydes that is naphthalene-1-carbaldehyde substituted by a hydroxy group at position 2. Active core of sirtinol (CHEBI:73158). | 2-hydroxy-1-naphthaldehyde |
| 2,6-dihydroxynaphthalene | 2,6-Dihydroxynaphthalene | |
| 4-hydroxypropranolol | 4'-hydroxypropanolol | |
| 6-bromo-2-naphthol | A member of the class of naphthols that is 2-naphthol carrying an additional bromo substituent at position 6. | 6-bromo-2-naphthol |
| 7-amino-4-hydroxy-2-naphthalenesulfonic acid | An aminonaphthalenesulfonic acid that is 2-naphthalenesulfonic acid substituted by an amino group at position 7 and a hydroxy group at position 4 respectively. | 7-amino-4-hydroxy-2-naphthalenesulfonic acid |
| allenolic acid | Allenolic acid | |
| aminaftone | aminaphthone | |
| dihydrobunolol | (+-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol | |
| dioncophylline c | An isoquinoline alkaloid that is the biaryl resulting from substitution of the hydrogen at the 5-position of (1R,3R)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol by a 5-hydroxy-4-methoxy-2-methylnaphthalen-1-yl group. It is a naphthylisoquinoline alkaloid isolated from the roots and stem barks of Triphyophyllum peltatum and exhibits antimalarial activity. | dioncophylline C |
| IPA-3 | An organic disulfide obtained by oxidative dimerisation of 1-sulfanylnaphthalen-2-ol. | IPA-3 |
| lasofoxifene | A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. | lasofoxifene |
| N-[(2-chlorophenyl)-(2-hydroxy-1-naphthalenyl)methyl]butanamide | N-[(2-chlorophenyl)-(2-hydroxy-1-naphthalenyl)methyl]butanamide | |
| N-[(2-hydroxy-1-naphthalenyl)-(4-methoxyphenyl)methyl]-2-methylpropanamide | N-[(2-hydroxy-1-naphthalenyl)-(4-methoxyphenyl)methyl]-2-methylpropanamide | |
| N-[(2-hydroxy-1-naphthalenyl)-(4-methylphenyl)methyl]cyclohexanecarboxamide | N-[(2-hydroxy-1-naphthalenyl)-(4-methylphenyl)methyl]cyclohexanecarboxamide | |
| N-[[(5-hydroxy-1-naphthalenyl)amino]-sulfanylidenemethyl]-2-furancarboxamide | N-[[(5-hydroxy-1-naphthalenyl)amino]-sulfanylidenemethyl]-2-furancarboxamide | |
| n'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide | A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. | dynasore |
| naphthol yellow | A naphthalenesulfonic acid that is naphthalene-2-sulfonic acid substituted by nitro groups at positions 5 and 7 as well as a hydroxy group at position 8. The disodium salt is the biological stain 'naphthol yellow S'. | flavianic acid |
| nepodin | Nepodin | |
| ponceau mx | A naphthalenesulfonic acid that is naphthalene-2,7-disulfonic acid carrying additional hydroxy and (2,4-dimethylphenyl)diazenyl substituents at positions 3 and 4 respectively. The disodium salt is the biological stain 'acid red 26'. | 4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid |
| scarlet red | A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan IV |
| sirtinol | A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine. | sirtinol |
| sudan iii | A bis(azo) compound that is 2-naphthol substituted at position 1 by a 4-{[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan III |
| vitamin k5 | 4-Amino-2-methyl-1-naphthol |
Research
Studies (918)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 183 (19.93) | 18.7374 |
| 1990's | 73 (7.95) | 18.2507 |
| 2000's | 230 (25.05) | 29.6817 |
| 2010's | 371 (40.41) | 24.3611 |
| 2020's | 61 (6.64) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 30 (2.86%) | 5.53% |
| Reviews | 43 (4.10%) | 6.00% |
| Case Studies | 9 (0.86%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 966 (92.18%) | 84.16% |