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macrocyclic lactone

Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule.

ChEBI ID: 63944

Members (8)

MemberDefinitionRole
22,23-dihydroavermectin b(1)aA macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.22,23-dihydroavermectin B1a
beta-lipotropin, gln(9)-A crown compound that is enterobactin in which the pro-R hydrogens at positions 2, 6 and 10 of the trilactone backbone are replaced by methyl groups, and in which a glycine spacer separates the trilactone backbone from each of the catecholamide arms. It is the endogenous siderophore of Bacillus subtilis, used for the acquisition of iron.corynebactin
riddelliine n-oxideA pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent.riddelliine N-oxide
sch 642305A macrocyclic lactone isolated from the fermentation broth of the fungal culture Penicillium verrucosum and has been shown to exhibit inhibitory activity against bacterial DNA primase enzyme.sch 642305
spiruchostatin bA spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth.spiruchostatin B
surfactin AA cyclodepsipeptide that is N-[(3R)-3-hydroxy-11-methyldodecanoyl]-L-alpha-glutamyl-L-leucyl-D-leucyl-L-valyl-L-alpha-aspartyl-D-leucyl-L-leucine in which the C-terminal carboxy group has been lactonised by condensation with the alcoholic hydroxy group.surfactin A
surfactin cA cyclodepsipeptide that is N-[(3R)-3-hydroxy-13-methyltetradecanoyl]-L-alpha-glutamyl-L-leucyl-D-leucyl-L-valyl-L-alpha-aspartyl-D-leucyl-L-leucine in which the C-terminal carboxy group has been lactonised by condensation with the alcoholic hydroxy group.surfactin C
wilforgineA dihydroagarofuran sesquiterpenoid and pyridine alkaloid with formula C41H47NO19 originally isolated from the roots of Tripterygium wilfordii.wilforgine

Research

Studies (121)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19904 (3.31)18.7374
1990's5 (4.13)18.2507
2000's42 (34.71)29.6817
2010's43 (35.54)24.3611
2020's27 (22.31)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1 (0.83%)5.53%
Reviews9 (7.44%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other111 (91.74%)84.16%