Page last updated: 2024-12-08

spinosin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

spinosin: isolated from seeds of Ziziph spinosa; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

spinosin : A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4', a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID155692
CHEBI ID81360
SCHEMBL ID2980651
MeSH IDM0156600

Synonyms (26)

Synonym
spinosin
6-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
72063-39-9
C17834
6-(2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4h-1-benzopyran-4-one
4h-1-benzopyran-4-one, 6-(2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
S9134
AKOS015897169
SCHEMBL2980651
(1s)-1,5-anhydro-2-o-beta-d-glucopyranosyl-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4h-1-benzopyran-6-yl]-d-glucitol
flavoayamenin
2''-o-glycosylswertisin
CHEBI:81360
DTXSID50222396
Q-100793
AC-31296
mfcd09754430
Q27155298
HY-N0651
6-((2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)tetrahydro-2h-pyran-2-yl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4h-chromen-4-one
BS-17968
HMS3886F18
CCG-270216
CS-0009676
A866326
P2887

Research Excerpts

Overview

Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var.

ExcerptReferenceRelevance
"Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. "( Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice.
Ahn, YJ; Jang, DS; Jo, YW; Jung, IH; Kang, SS; Kim, JS; Kwon, G; Lee, HE; Lee, SY; Park, SJ; Ryu, JH; Woo, H, 2014
)
2.16

Treatment

ExcerptReferenceRelevance
"Treatments of spinosin and 6'''‑feruloylspinosin led to the reduction of glycogen synthase kinase‑3β (GSK3β) phosphorylation at Tyr216, and the increase of peroxisome proliferator‑activated receptor γ coactivator (PGC)‑1α and its downstream signaling proteins, including nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) and hemeoxygenase1 (HO‑1)."( Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Cheng, S; Gu, M; Gu, Y; He, P; Jia, Y; Liu, X; Lyu, C; Xu, Y, 2019
)
2.3

Pharmacokinetics

ExcerptReferenceRelevance
" The main pharmacokinetic parameters T(0."( Pharmacokinetics and tissue distribution of spinosin after intravenous administration in rats.
Dai, YH; Deng, YL; Li, Y; Li, YJ; Yu, YL, 2007
)
0.6
" The validated method has been successfully applied to comparing pharmacokinetic profiles of analytes in rat plasma."( A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats.
Bi, K; Chen, X; He, B; Jia, Y; Li, Q; Lv, C; Xiao, F; Xu, H; Zhao, L, 2012
)
0.63
"To study the pharmacokinetic effect of different combined administration with monarch drug Ziziphi Spinosae Semen on its main components in rats."( [Pharmacokinetic effect of combined administration on spinosin and ferulic acid in monarch drug Ziziphi Spinosae Semen kernel].
Chen, XJ; Fang, MF; Gao, R; Li, S; Wang, SX; Wang, XF, 2015
)
0.67

Bioavailability

ExcerptReferenceRelevance
"The results showed that the absorption rate constant (0."( The preparation and investigation of spinosin-phospholipid complex self-microemulsifying drug delivery system based on the absorption characteristics of spinosin.
Lai, C; Song, P; Xie, J; Zhang, Y, 2019
)
0.79

Dosage Studied

ExcerptRelevanceReference
"The aim of this research was to investigate the intestinal absorption characteristics and mechanisms of spinosin (SPI), and a new dosage form was prepared to increase the intestinal absorption of SPI."( The preparation and investigation of spinosin-phospholipid complex self-microemulsifying drug delivery system based on the absorption characteristics of spinosin.
Lai, C; Song, P; Xie, J; Zhang, Y, 2019
)
1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
anxiolytic drugAnxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
flavone C-glycosideAny C-glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a flavone skeleton, thus creating a C-C bond.
dihydroxyflavoneAny hydroxyflavone in which two ring hydrogens are replaced by hydroxy substituents.
monomethoxyflavoneAny methoxyflavone with a single methoxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.56)18.7374
1990's0 (0.00)18.2507
2000's7 (17.95)29.6817
2010's22 (56.41)24.3611
2020's9 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.25 (24.57)
Research Supply Index3.69 (2.92)
Research Growth Index4.89 (4.65)
Search Engine Demand Index42.09 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other39 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]