| Assay ID | Title | Year | Journal | Article |
|---|
| AID720501 | qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds | 2012 | PloS one, , Volume: 7, Issue:10
| A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1199849 | Fluorescence quenching in HTS buffer assessed as fluorescence signal reduction at 10 uM after 10 mins | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1736891 | Antiproliferative activity against human RPMI-8226 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736899 | Induction of apoptosis in human KM3 cells assessed as early apoptotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 2.18%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1683278 | Inhibition of Bcl2 (unknown origin) using 5-FAM-Bid-BH3 as substrate incubated for 30 mins followed by substrate addition and measured after 20 mins by fluorescence polarization assay | 2021 | Bioorganic & medicinal chemistry, 01-01, Volume: 29 | Synthesis and evaluation of a UMI-77-based fluorescent probe for selective detecting Mcl-1 protein and imaging in living cancer cells. |
| AID1736889 | Antiproliferative activity against human KM3 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1140901 | Cytotoxicity against human K562 cells assessed as intracellular ATP level after 3 days by CellTiterGlo assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1199847 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K27 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1199846 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K56 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1199857 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1127817 | Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotropy assay | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search. |
| AID1736907 | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.71%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736915 | Induction of apoptosis in human HepG2 cells at 10 to 20 uM measured after 48 hrs by TUNEL staining based fluorescence microscopy | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736886 | Inhibition of 5-FAM-BH3 peptide binding to human N-terminal GST-tagged BCL-XL (1 to 212 residues) expressed in Escherichia coli BL21 (DE3) at 100 uM by fluorescence polarization assay relative to control | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736894 | Antiproliferative activity against human PC-3 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1199850 | Fluorescence quenching in HTS buffer with 7.5 uM CoA assessed as fluorescence signal reduction at 10 uM after 10 mins | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1140900 | Cytotoxicity against human MV4-11 cells assessed as intracellular ATP level after 3 days by CellTiterGlo assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1140883 | Binding affinity to His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of MCL1-N-terminal biotin-labeled BIM BH3 peptide interaction after 30 mins by surface plasmon resonance analysis | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1736912 | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.93%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736895 | Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1352836 | Inhibition of MCL1 (unknown origin) by fluorescence polarization assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. |
| AID1199845 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CoA-based HTS counter screen assay | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1140899 | Cytotoxicity against human HL60 cells assessed as intracellular ATP level after 3 days by CellTiterGlo assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1199854 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1736911 | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.71%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1140884 | Displacement of Flu-BID/FAM-BID from His-tagged BCL2 (1 to 202) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1736906 | Induction of apoptosis in human HepG2 cells assessed as viable cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 96.84%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736892 | Antiproliferative activity against human Jurkat cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1140879 | Displacement of Flu-BID/FAM-BID from His-tagged A1-BFL-1 (1 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1736904 | Induction of apoptosis in human KM3 cells assessed as late apoptotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.15%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736908 | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.93%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736909 | Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.52%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1599476 | Inhibition of human MCl-1 by fluorescence polarization assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | The chemical biology of apoptosis: Revisited after 17 years. |
| AID1736887 | Inhibition of 5-FAM-BH3 peptide binding to human N-terminal GST-tagged BCL-2 (1 to 34 residues)/BCL-XL (29 to 44 residues)/BCL-2 isoform 2 (92 to 207 residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736902 | Induction of apoptosis in human KM3 cells assessed as viable cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 96.24%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1544723 | Inhibition of 5-FAM-tagged Bid-BH3 peptide binding to Bcl2 (unknown origin) by fluorescence polarization assay | 2019 | Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
| Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. |
| AID1199858 | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1736900 | Induction of apoptosis in human KM3 cells assessed as late apoptotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.15%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1199859 | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1736903 | Induction of apoptosis in human KM3 cells assessed as early apoptotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 2.18%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736890 | Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1199855 | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1683279 | Inhibition of Mcl-1 (unknown origin) using 5-FAM-Bid-BH3 as substrate incubated for 30 mins followed by substrate addition and measured after 20 mins by fluorescence polarization assay | 2021 | Bioorganic & medicinal chemistry, 01-01, Volume: 29 | Synthesis and evaluation of a UMI-77-based fluorescent probe for selective detecting Mcl-1 protein and imaging in living cancer cells. |
| AID1736885 | Inhibition of 5-FAM-BH3 peptide binding to N-terminal His8-tagged human MCL-1 (209 to 327 residues)/mouse MCL-1 (152 to 189 residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1544725 | Inhibition of 5-FAM-tagged Bid-BH3 peptide binding to Mcl1 (unknown origin) by fluorescence polarization assay | 2019 | Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
| Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. |
| AID1736893 | Antiproliferative activity against human MOLT-4 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736901 | Induction of apoptosis in human KM3 cells assessed as necrotic cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.42%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1199862 | Fluorescence quenching in HTS buffer with 20 uM 7-diethylamino-3-(4'-maleimidyl-phenyl)-4-methylcoumarin assessed as fluorescence signal reduction at 10 uM after 10 mins | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1199856 | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1140885 | Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1736910 | Induction of apoptosis in human HepG2 cells assessed as viable cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 96.84%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1736898 | Induction of apoptosis in human KM3 cells assessed as viable cells at 10 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 96.24%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1140886 | Displacement of Flu-BID/FAM-BID from His-tagged BCLX-L (1 to 209) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1199844 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CPM based HTS assay | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1544724 | Inhibition of 5-FAM-tagged Bid-BH3 peptide binding to Bcl-XL (unknown origin) by fluorescence polarization assay | 2019 | Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
| Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. |
| AID1736913 | Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.52%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1199848 | Fluorescence quenching assessed as fluorescence signal reduction at 10 uM after 10 mins | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5
| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1140882 | Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| AID1736905 | Induction of apoptosis in human KM3 cells assessed as necrotic cells at 20 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.42%) | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. |
| AID1140891 | Inhibition of MCL1-biotin-labeled NOXA interaction in human 2LMP whole cell lysate at 100 uM by Western blotting analysis | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |