Compounds > Kumatakenin
Page last updated: 2024-08-01 16:02:00

Kumatakenin

Description

Kumatakenin : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5318869
CHEMBL ID349724
SCHEMBL ID3351483
CHEBI ID176665

Synonyms (39)

Synonym
jaranol
CHEBI:176665
5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxychromen-4-one
kaempferol 3,7-dimethyl ether
MEGXP0_000177
3301-49-3
kumatakenin
5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-chromen-4-one
4h-1-benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-
ACON1_000321
NCGC00169188-01
CHEMBL349724
kumatakillin
5,4'-dihydroxy-3,7-dimethoxyflavone
LMPK12112690
5faq11412t ,
unii-5faq11412t
3,7-di-o-methyl kaempferol
4',5-dihydroxy-3,7-dimethoxyflavone
kaempferol 3,7-o-dimethyl ether
kumatakenin a
flavone, 4',5-dihydroxy-3,7-dimethoxy-
3,7-dimethylkaempferol
kamatakenin
SCHEMBL3351483
5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4h-chromen-4-one #
BJBUTJQYZDYRMJ-UHFFFAOYSA-N
DTXSID90186645 ,
AKOS032948397
HY-N3415
5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4h-chromen-4-one
[2,2,2]-paracyclophane
Q10910637
CS-0024175
MS-24602
5,4''-dihydroxy-3,7-dimethoxyflavone
XK161815
E80609
dtxcid30109136

Drug Classes (2)

ClassDescription
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.

Bioassays (26)

Assay IDTitleYearJournalArticle
AID1651899Cytotoxicity against human insulin resistant HepG2 cells assessed as cell viability at 10 uM by CCK8 assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
ISSN: 1520-6025
AID199695Cytotoxic dose at which 50% growth of normal cells is inhibited against rhino virus infection.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID199696Minimum drug concentration at which 99% of the rhino virus is inhibited.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID1198229Antitrypanosomal activity against Trypanosoma brucei gambiense Feo assessed as parasite growth inhibition at 10 uM after 72 hrs by fluorescence assay relative to control2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID1651897Inhibition of recombinant human PTP1B (1 to 321 residues) expressed in Escherichia coli at 10 uM using p-nitrophenyl phosphate as substrate incubated for 30 mins relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
ISSN: 1520-6025
AID162249Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3)1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID235261Therapeutic Index measured as the ratio of CyD50 (rhino) / ED99 (rhino) values.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID458821Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase by noncompetitive inhibition assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
ISSN: 1464-3405		Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID1198228Antitrypanosomal activity against Trypanosoma brucei gambiense Feo assessed as parasite growth inhibition at 50 uM after 72 hrs by fluorescence assay relative to control2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID235260Therapeutic Index measured as the ratio of CyD50(polio) / ED99(polio) values1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID1546537Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
ISSN: 1464-3391		Artemisia: a promising plant for the treatment of cancer.
AID1198226Antiplasmodial activity against Plasmodium falciparum FcB1/Columbia infected in human red blood cells assessed as parasite growth inhibition at 10 uM after 48 hrs by [3H]-hypoxanthine incorporation assay relative to control2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID319548Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release2008Journal of natural products, Jan, Volume: 71, Issue:1
ISSN: 0163-3864		Benzoic acid derivatives, acetophenones, and anti-inflammatory constituents from Melicope semecarpifolia.
AID1651898Inhibition of alpha-Glucosidase (unknown origin) at 10 uM using pNPG as substrate incubated for 30 mins relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
ISSN: 1520-6025
AID162244The ratio of the poliovirus viral titer of the virus control (reduction factor) to the viral titer in the presence of the maximal non-toxic dose (RF MNTD)1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID1546536Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
ISSN: 1464-3391		Artemisia: a promising plant for the treatment of cancer.
AID458820Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
ISSN: 1464-3405		Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID1198221Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID1198220Cytotoxicity against rat L6 cells assessed as viable cells at 1 uM after 72 hrs by MTT assay relative to control2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID1198222Antivascular activity in human EAhy926 cells assessed as concentration require to adopt rounding shape after 2 hrs by microscopic analysis2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID162237Cytotoxic dose at which 50% growth of normal cells is inhibited1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID319546Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation2008Journal of natural products, Jan, Volume: 71, Issue:1
ISSN: 0163-3864		Benzoic acid derivatives, acetophenones, and anti-inflammatory constituents from Melicope semecarpifolia.
AID162238Minimum drug concentration at which 99% of the polio virus is inhibited1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
AID1198225Leishmanicidal activity against promastigote stage of Leishmania amazonensis MHOM/BR/PH8 after 48 hrs by MTT assay2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID1198219Cytotoxicity against rat L6 cells assessed as viable cells at 10 uM after 72 hrs by MTT assay relative to control2015European journal of medicinal chemistry, Mar-26, Volume: 93ISSN: 1768-3254Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
AID162242Maximal non-toxic dose (MNTD) that shows antiviral activity.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
ISSN: 0022-2623		4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
dimefline
0
ether;
flavonoids		00low000000
hesperetin
0
ether;
flavonoids		00low000000
4'-methoxyflavone
0
ether;
flavonoids		00low000000
5,7,4'-trimethylapigenin
0
ether;
flavonoids		00low000000
5-Methoxyflavone
0
ether;
flavonoids		00low000000
cellulose sulfate
0
ether;
flavonoids		00low000000
nepitrin
0
flavonoids;
glycoside		00low000000
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
0
ether;
flavonoids		00low000000
2'-methoxyflavone
0
ether;
flavonoids		00low000000
6-methoxyflavone
0
ether;
flavonoids		00low000000
3,3',4',5,6,7,8-heptamethoxyflavone
0
ether;
flavonoids		00low000000
sideritoflavone
0
ether;
flavonoids		00low000000
cirsimarin
0
flavonoids;
glycoside		00low000000
3'-demethylnobiletin
0
ether;
flavonoids		00low000000
3',4',5'-trimethoxyflavone
0
ether;
flavonoids		00low000000
5-demethylnobiletin
0
ether;
flavonoids		00low000000
5-Hydroxy-7-methoxy-6-methylflavone
0
ether;
flavonoids		00low000000
5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
7-methoxyflavone
0
ether;
flavonoids		00low000000
negletein
0
ether;
flavonoids		00low000000
5-hydroxy-6,7-dimethoxyflavone
0
ether;
flavonoids		00low000000
zapotin
0
ether;
flavonoids		00low000000
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
0
ether;
flavonoids		00low000000
6-methoxy-2-(3-methoxyphenyl)-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
3,7-dimethoxyflavone
0
ether;
flavonoids		00low000000
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
N-(2-ethylphenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-1-benzopyran-6-yl]oxy]acetamide
0
ether;
flavonoids		00low000000
6,3',4'-Trimethoxyflavanone
0
ether;
flavonoids		00low000000
demethoxysudachitin
0
ether;
flavonoids		00low000000
hidrosmin
0
flavonoids;
glycoside		00low000000
2-[[2-(4-methoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]-4-methylpentanoic acid
0
ether;
flavonoids		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one
0
C-glycosyl compound;
flavonoids		00low000000
2-[[2-(3,4-dimethoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]butanoic acid
0
ether;
flavonoids		00low000000
6-(5,6-Dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
0
flavonoids;
glucosiduronic acid		00low000000
alpinetin
0
ether;
flavonoids		00low000000
isovitexin
0
C-glycosyl compound;
flavonoids		00low000000
7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
rutin
0
flavonoids;
glycoside		00low000000
hydroxygenkwanin
0
ether;
flavonoids		00low000000
juglanin
0
flavonoids;
glycoside		00low000000
kaempferol 3-o-neohesperidoside
0
flavonoids;
glycoside		00low000000
apigenin-7-o-beta-d-glucuronide
0
flavonoids;
glucosiduronic acid		00low000000
neoisoliquiritin
0
flavonoids;
glycoside		00low000000
artemetin
0
ether;
flavonoids		00low000000
Diosmetin rutinoside
0
flavonoids;
glycoside		00low000000
apigenin-7-o-glucuronide
0
flavonoids;
glucosiduronic acid		00low000000
ternatin (flavonoid)
0
ether;
flavonoids		00low000000
icarrin
0
flavonoids;
glycoside		00low000000
vitexin rhamnoside
0
flavonoids;
glycoside		00low000000
epimedin b
0
flavonoids;
glycoside		00low000000
epimedin c
0
flavonoids;
glycoside		00low000000
hesperidin
0
flavonoids;
glycoside		00low000000
1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]hexitol
0
C-glycosyl compound;
flavonoids		00low000000
marein
0
flavonoids;
glycoside		00low000000
isoliquiritin apioside
0
flavonoids;
glycoside		00low000000
2''-galloylhyperin
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one
0
C-glycosyl compound;
flavonoids		00low000000
pinostrobin
0
ether;
flavonoids		00low000000
7-monohydroxyethylrutoside
0
flavonoids;
glycoside		00low000000
sagittatoside b
0
flavonoids;
glycoside		00low000000
calycopterin
0
ether;
flavonoids		00low000000
Diosmetin 7-O-beta-D-glucopyranoside
0
flavonoids;
glycoside		00low000000
5-Hydroxyauranetin
0
ether;
flavonoids		00low000000
Asebotin
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside
0
flavonoids;
glycoside		00low000000
sudachitin
0
ether;
flavonoids		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 2-O-hexopyranosylhexopyranoside
0
flavonoids;
glycoside		00low000000
3'',4''-Diacetylafzelin
0
flavonoids;
glycoside		00low000000
didymin
0
flavonoids;
glycoside		00low000000
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone
0
ether;
flavonoids		00low000000
multiflorin a
0
flavonoids;
glycoside		00low000000
typhaneoside
0
flavonoids;
glycoside		00low000000
acebutolol
0
aromatic amide;
ethanolamines;
ether;
monocarboxylic acid amide;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent		00low000000
cetirizine
0
ether;
monocarboxylic acid;
monochlorobenzenes;
piperazines		anti-allergic agent;
environmental contaminant;
H1-receptor antagonist;
xenobiotic		00low000000
diphenhydramine
0
ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative		00low000000
econazole
0
dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes		00low000000
enflurane
0
ether;
organochlorine compound;
organofluorine compound		anaesthetic00low000000
eprazinone
0
aromatic ketone;
ether;
N-alkylpiperazine		mucolytic00low000000
ether
0
ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant		00low000000
vanoxerine
0
ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor00low000000
gbr 12935
0
ether;
N-alkylpiperazine;
tertiary amino compound		dopamine uptake inhibitor00low000000
isoconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
ketoconazole
0
dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine		00low000000
methoxyflurane
0
ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic		00low000000
metolachlor
0
aromatic amide;
benzenes;
ether;
organochlorine compound		00low000000
miconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
orphenadrine
0
ether;
tertiary amino compound		antidyskinesia agent;
antiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist;
muscle relaxant;
NMDA receptor antagonist;
parasympatholytic		00low000000
salmeterol xinafoate
0
ether;
phenols;
primary alcohol;
secondary alcohol;
secondary amino compound		00low000000
sevoflurane
0
ether;
organofluorine compound		central nervous system depressant;
inhalation anaesthetic;
platelet aggregation inhibitor		00low000000
tioconazole
0
dichlorobenzene;
ether;
imidazoles;
thiophenes		00low000000
chloromethyl methyl ether
0
ether00low000000
bis(2-chloro-1-methylethyl) ether
0
ether00low000000
vinyl ether
0
ether00low000000
bis(2-chloroethyl)ether
0
ether00low000000
butyl carbitol
0
ether00low000000
dimethyl ether
0
ether00low000000
flurothyl
0
ether00low000000
bis(chloromethyl) ether
0
ether;
organochlorine compound		alkylating agent;
carcinogenic agent		00low000000
methoxyacetic acid
0
ether;
monocarboxylic acid		antineoplastic agent;
apoptosis inducer;
human xenobiotic metabolite;
mutagen		00low000000
ethyl tert-butyl ether
0
ether;
volatile organic compound		fuel additive00low000000
methyl tert-butyl ether
0
etherfuel additive;
metabolite;
non-polar solvent		00low000000
mitomycin a
0
ether;
mitomycin		alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin		00low000000
ethofumesate
0
1-benzofurans;
ether;
methanesulfonate ester		00low000000
enilconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
sufentanil
0
anilide;
ether;
piperidines;
thiophenes		anaesthesia adjuvant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic		00low000000
metalaxyl
0
alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester		00low000000
fenticonazole
0
aryl sulfide;
dichlorobenzene;
ether;
imidazoles		00low000000
oxadixyl
0
anilide fungicide;
aromatic amide;
carbohydrazide;
ether;
oxazolidinone		agrochemical00low000000
adefovir
0
6-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent		00low000000
adefovir dipivoxil
0
6-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug		00low000000
sertaconazole
0
1-benzothiophenes;
dichlorobenzene;
ether;
imidazoles		00low000000
tetraconazole
0
dichlorobenzene;
ether;
organofluorine compound;
triazoles		00low000000
raptors
0
ether;
imidazolines;
imidazolone;
pyridinemonocarboxylic acid		00low000000
dimethenamid
0
aromatic amide;
ether;
organochlorine compound;
thiophenes		00low000000
2'-o-methyladenosine
0
adenosines;
ether		fungal metabolite00low000000
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole
0
ether;
imidazoles;
monomethoxybenzene		TRP channel blocker00low000000
o-methyl threonine
0
ether;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid		antibacterial agent;
bleaching agent		00low000000
mycophenolate mofetil
0
carboxylic ester;
ether;
gamma-lactone;
phenols;
tertiary amino compound		anticoronaviral agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
immunosuppressive agent;
prodrug		00low000000
soraphen a
0
cyclic hemiketal;
ether;
macrolide;
olefinic compound		bacterial metabolite;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
teratogenic agent		00low000000
l 683590
0
ether;
lactol;
macrolide;
secondary alcohol		antifungal agent;
bacterial metabolite;
immunosuppressive agent		00low000000
acetylspiramycin
0
acetate ester;
aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite		00low000000
sirolimus
0
antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor		00low000000
oripavine
0
ether;
morphinane alkaloid;
organic heteropentacyclic compound;
organic hydroxy compound;
tertiary amino compound		bacterial xenobiotic metabolite;
opioid analgesic		00low000000
bongkrekic acid
0
ether;
olefinic compound;
tricarboxylic acid		apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin		00low000000
demycarosylturimycin h
0
aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite		00low000000
everolimus
0
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
primary alcohol;
secondary alcohol		anticoronaviral agent;
antineoplastic agent;
geroprotector;
immunosuppressive agent;
mTOR inhibitor		00low000000
l 744832
0
benzenes;
ether;
isopropyl ester;
secondary carboxamide;
sulfone;
thiol		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
geroprotector		00low000000
gs-7340
0
6-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug		00low000000
estin
0
1-benzofurans;
ether;
methyl ester;
organochlorine compound;
oxaspiro compound;
phenols		Aspergillus metabolite;
Penicillium metabolite		00low000000
selexipag
0
aromatic amine;
ether;
monocarboxylic acid amide;
N-sulfonylcarboxamide;
pyrazines;
tertiary amino compound		orphan drug;
platelet aggregation inhibitor;
prodrug;
prostacyclin receptor agonist;
vasodilator agent		00low000000
mre 269
0
aromatic amine;
ether;
monocarboxylic acid;
pyrazines;
sulfonamide;
tertiary amino compound		drug metabolite;
orphan drug;
platelet aggregation inhibitor;
prostacyclin receptor agonist;
vasodilator agent		00low000000
vilanterol
0
benzyl alcohols;
dichlorobenzene;
ether;
phenols;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent		00low000000
rolapitant
0
azaspiro compound;
ether;
organofluorine compound;
piperidines;
pyrrolidin-2-ones		antiemetic;
neurokinin-1 receptor antagonist		00low000000
iejimalide b
0
ether;
formamides;
macrolide		antineoplastic agent;
marine metabolite		00low000000
migrastatin
0
ether;
macrolide antibiotic;
piperidones;
secondary alcohol		antineoplastic agent;
metabolite		00low000000
episilvestrol
0
dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite		00low000000
tembotrione
0
aromatic ketone;
beta-triketone;
cyclic ketone;
ether;
monochlorobenzenes;
organofluorine compound;
sulfone		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
herbicide		00low000000
silvestrol
0
dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite		00low000000
cytotrienin a
0
cyclopropanecarboxylate ester;
ether;
hydroquinones;
lactam;
macrocycle;
secondary alcohol		antibacterial agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
metabolite		00low000000
nodularin
0
ether00low000000
debromoaplysiatoxin
0
aplysiatoxins;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
phenols;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist		00low000000
aplysiatoxin
0
aplysiatoxins;
bromophenol;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist		00low000000
novobiocin
0
carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent		00low000000
gs-5816
0
carbamate ester;
ether;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heteropentacyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor		00low000000
althiomycin
0
1,3-thiazoles;
aldoxime;
ether;
gamma-lactam;
pentapeptide;
peptide antibiotic;
primary alcohol;
pyrroline;
secondary carboxamide;
tertiary carboxamide		antibacterial agent;
bacterial metabolite;
protein synthesis inhibitor		00low000000
marineosin a
0
azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite		00low000000
marineosin b
0
azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
chloroquine
1
aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug		201520159.0low000010
diphenyleneiodonium
1
organic cation2008200816.0low000100
guanidine
1
carboxamidine;
guanidines;
one-carbon compound		1991199133.0low001000
pentamidine
1
aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic		201520159.0low000010
phenylmethylsulfonyl fluoride
1
acyl fluorideserine proteinase inhibitor2008200816.0low000100
colchicine
1
alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen		201520159.0low000010
scoparone
1
aromatic ether;
coumarins		anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite		202020204.0low000010
capillin
1
aromatic ketone;
ynone		202020204.0low000010
paclitaxel
1
taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent		202020204.0low000010
oseltamivir
1
acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic		2010201014.0low000100
artemisinin
1
organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite		202020204.0low000010
artemether
1
artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid		antimalarial202020204.0low000010
sesamin
1
benzodioxoles;
furofuran;
lignan		antineoplastic agent;
neuroprotective agent;
plant metabolite		202020204.0low000010
isoalantolactone
1
eudesmane sesquiterpenoid;
sesquiterpene lactone		antifungal agent;
apoptosis inducer;
plant metabolite		202020204.0low000010
eupatorin
1
dihydroxyflavone;
polyphenol;
trimethoxyflavone		anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
Brassica napus metabolite;
calcium channel blocker;
P450 inhibitor;
vasodilator agent		202020204.0low000010
triptolide
1
diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite		202020204.0low000010
liquiritigenin
1
4',7-dihydroxyflavanonehormone agonist;
plant metabolite		2010201014.0low000100
gu 7
1
isoflavonoid;
organic hydroxy compound		2010201014.0high000100
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
1
ether;
flavonoids		1991199133.0low001000
3,3',4',5,6,7,8-heptamethoxyflavone
1
ether;
flavonoids		1991199133.0low001000
5-hydroxy-3',4',6,7-tetramethoxyflavone
1
202020204.0low000010
cirsiliol
1
dimethoxyflavone;
trihydroxyflavone		plant metabolite202020204.0low000010
3-hydroxystigmast-5-en-7-one
1
steroid2008200816.0medium000100
cirsilineol
1
dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite		202020204.0low000010
leucodin
1
sesquiterpene lactone202020204.0low000010
yomogin
1
202020204.0medium000010
lupeol
1
pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite		202020204.0low000010
ononin
1
4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative		plant metabolite2010201014.0low000100
artenimol
1
202020204.0low000010
glycyrin
1
aromatic ether;
coumarins;
hydroxyisoflavans		antibacterial agent;
metabolite;
plant metabolite		2010201014.0medium000100
glyasperin D
1
aromatic ether;
hydroxyisoflavans;
methoxyisoflavan		plant metabolite2010201014.0low000100
licocoumarone
1
1-benzofurans;
aromatic ether;
resorcinols		antibacterial agent;
apoptosis inducer;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite		2010201014.0medium000100
likviriton
1
beta-D-glucoside;
flavanone glycoside;
monohydroxyflavanone;
monosaccharide derivative		anti-inflammatory agent;
anticoronaviral agent;
plant metabolite		2010201014.0low000100
isoliquiritigenin
1
chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist		2010201014.0low000100
chlorogenic acid
1
cinnamate ester;
tannin		food component;
plant metabolite		202020204.0low000010
artemotil
1
artemisinin derivative202020204.0low000010
Artemin
1
sesquiterpene lactone202020204.0medium000010
eupatilin
1
dihydroxyflavone;
trimethoxyflavone		anti-inflammatory agent;
anti-ulcer drug;
antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
metabolite		202020204.0low000010
quercetin
1
7-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger		1991199133.0low001000
3,7-dimethoxy-5,3',4'-trihydroxyflavone
1
dimethoxyflavone;
trihydroxyflavone		EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor;
metabolite		1991199133.0low001000
acacetin
1
dihydroxyflavone;
monomethoxyflavone		anticonvulsant;
plant metabolite		202020204.0low000010
apigenin
1
trihydroxyflavoneantineoplastic agent;
metabolite		202020204.0low000010
luteolin
1
3'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist		202020204.0low000010
scopoletin
1
hydroxycoumarinplant growth regulator;
plant metabolite		202020204.0low000010
quercetin 3-o-methyl ether
1
monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite		1991199133.0low001000
3-methylkaempferol
2
monomethoxyflavone;
trihydroxyflavone		plant metabolite1991201521.0medium001010
kaempferol
1
7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite		201520159.0low000010
amphotericin b
1
antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite		201520159.0low000010
capillarisin
1
coumarins202020204.0low000010
genkwanin
1
dihydroxyflavone;
monomethoxyflavone		metabolite202020204.0low000010
3-methylquercetin
1
7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone		anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite		202020204.0low000010
pachypodol
2
dihydroxyflavone;
trimethoxyflavone		antiemetic;
plant metabolite		1991200824.5medium001100
santin
2
dihydroxyflavone;
trimethoxyflavone		plant metabolite1991201521.0medium001010
isofraxidin
1
hydroxycoumarin202020204.0low000010
3-deoxysappanchalcone
1
chalcones;
monomethoxybenzene;
phenols		metabolite2010201014.0low000100
neoglycyrol
1
aromatic ether;
coumestans;
delta-lactone;
polyphenol		antineoplastic agent;
plant metabolite		2010201014.0low000100
artemetin
1
ether;
flavonoids		202020204.0low000010
5,4'-dihydroxy-3,6,7-trimethoxyflavone
1
1991199133.0medium001000
fosbretabulin
1
stilbenoid201520159.0low000010
ermanin
1
dihydroxyflavone;
dimethoxyflavone		anti-inflammatory agent;
antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
plant metabolite		1991199133.0low001000
5-hydroxy-3,3',4',7-tetramethoxyflavone
2
3'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone		plant metabolite1991200824.5medium001100
4',5,7-trihydroxy-3,6-dimethoxyflavone
2
1991201521.0medium001010
jaceosidin
1
dimethoxyflavone;
trihydroxyflavone		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
metabolite		202020204.0low000010
artesunate
1
artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer		202020204.0low000010
ludartin
1
202020204.0medium000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Benign Neoplasms0
1
202020204.0high000010
Experimental Neoplasms0
1
202020204.0high000010
Neoplasms0
1
202020204.0high000010