Compounds > pentabromopseudilin
Page last updated: 2024-11-08

pentabromopseudilin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pentabromopseudilin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID324093
CHEMBL ID1235156
CHEBI ID70619
SCHEMBL ID3992636
MeSH IDM0248750

Synonyms (41)

Synonym
pbq ,
pentabromopseudilin
chebi:70619 ,
CHEMBL1235156 ,
nsc641543
nsc-641543
dibromo-6-(3,5-tribromopyrrol-2-yl)-phenol
10245-81-5
nsc-288032
nsc288032
phenol,4-dibromo-6-(3,4,5-tribromo-1h-pyrrol-2-yl)-
phenol,4-dibromo-6-(3,4,5-tribromopyrrol-2-yl)-
2,4-dibromo-6-(3,4,5-tribromo-1h-pyrrol-2-yl)phenol
phenol, 2,4-dibromo-6-(3,4,5-tribromo-1h-pyrrol-2-yl)-
inchi=1/c10h4br5no/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17
SCHEMBL3992636
bdbm50345502
2,4-dibromo-6-(2,4,5-tribromo-3-pyrrolyl)phenol
niosh/sk8150000
lovell substance
pyrrolantibiotic
bromine rich marine antibiotic
SK81500000
phenol, 2,4-dibromo-6-(2,4,5-tribromo-3-pyrrolyl)-
3,4,5-tribromo-2-( 3,5-dibromo-2-hydroxyphenyl )pyrrole
LXMNWKJHYOZUQL-UHFFFAOYSA-N
(1h)pyrrole, 2,3,4-tribromo-5-(2,4-dibromo-phenol-6-yl)-
dibromo-6-(3,4,5-tribromopyrrol-2-yl)-phenol
2,4-dibromo-6-(3,4,5-tribromo-1h-pyrrol-2-yl)phenol #
phenol, 2,4-dibromo-6-(3,4,5-tribromopyrrol-2-yl)-
2-(3,5-dibromo-2-hydroxyphenyl)-3,4,5-tribromopyrrol; 2,4-dibromo-6-(3,4,5-tribromo-1h-pyrrol-2-yl)phenol
c10h4br5no
HB4021
nsc641543; nsc288032
4NAK
DTXSID90314744
Q27138952
BUV7D4FJ9V ,
unii-buv7d4fj9v
HY-113604
CS-0062693

Research Excerpts

Overview

Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus.

ExcerptReferenceRelevance
"Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. "( Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation.
Chen, CL; Chih-Ling, C; Kao, YC; Knölker, HJ; Martin, R; Shiao, MS; Shih-Wei, W, 2018)		3.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
pyrrolesAn azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Myosin light chain kinase 2, skeletal/cardiac muscleOryctolagus cuniculus (rabbit)IC50 (µMol)5.10005.10005.10005.1000AID1693691
Unconventional myosin-VaGallus gallus (chicken)IC50 (µMol)1.20001.20001.20001.2000AID600880
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
vesicle-mediated transportUnconventional myosin-VaGallus gallus (chicken)
cellular response to insulin stimulusUnconventional myosin-VaGallus gallus (chicken)
protein localization to plasma membraneUnconventional myosin-VaGallus gallus (chicken)
vesicle transport along actin filamentUnconventional myosin-VaGallus gallus (chicken)
actin filament organizationUnconventional myosin-VaGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
microfilament motor activityUnconventional myosin-VaGallus gallus (chicken)
protein bindingUnconventional myosin-VaGallus gallus (chicken)
calmodulin bindingUnconventional myosin-VaGallus gallus (chicken)
ATP bindingUnconventional myosin-VaGallus gallus (chicken)
minus-end directed microfilament motor activityUnconventional myosin-VaGallus gallus (chicken)
actin filament bindingUnconventional myosin-VaGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
Golgi membraneUnconventional myosin-VaGallus gallus (chicken)
insulin-responsive compartmentUnconventional myosin-VaGallus gallus (chicken)
myosin complexUnconventional myosin-VaGallus gallus (chicken)
filamentous actinUnconventional myosin-VaGallus gallus (chicken)
actin cytoskeletonUnconventional myosin-VaGallus gallus (chicken)
vesicleUnconventional myosin-VaGallus gallus (chicken)
membraneUnconventional myosin-VaGallus gallus (chicken)
cytoplasmUnconventional myosin-VaGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1693698Antimigratory activity against human MDA-MB-231 cells assessed as cell migration at 2.5 uM by light microscopy relative to control2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693700Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 4 hrs by neutral red uptake assay2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693695Induction of cell morphological changes in human MDA-MB-231 cells assessed as membrane blebbing by inverted microscopy2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693704Cardiotoxicity in medaka embryo post hatching 24 hrs assessed as reduction in heart beat at 1.25 uM measured after 1 hr2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID550005Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 12 hrs by Broth microdilution method2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Highly brominated antimicrobial metabolites from a marine Pseudoalteromonas sp.
AID600880Inhibition of chicken myosin 5a assessed as ATP hydrolysis2011Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.
AID600882Inhibition of Dictyostelium discoideum myosin 2 motor domain-activated ATPase activity by spectrophotometry based PK/LDH coupled ATPase assay2011Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.
AID1693691Inhibition of rabbit skeletal muscle myosin-2 ATPase incubated for 20 mins followed by ATP addition and measured after 20 mins2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693705Antimigratory activity against human MDA-MB-231 cells assessed as cell migration by light microscopy2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693690Inhibition of rabbit muscle G-actin polymerization assessed as polymerized G-actin level at 25 uM incubated for 15 mins by spectrophotometric analysis (Rvb = 100 %)2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID1693699Antimigratory activity against human MDA-MB-231 cells assessed as minimum effective concentration by light microscopy2021Bioorganic & medicinal chemistry, 01-15, Volume: 30In vitro and in vivo effects of inhibitors on actin and myosin.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2014Angewandte Chemie (International ed. in English), Feb-17, Volume: 53, Issue:8
Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's7 (53.85)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.03 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.09 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pargyline
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.		2.4420aromatic amine
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.76100pyrrole;
secondary amine
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0510glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
rhenium
Rhenium: A metal, atomic number 75, atomic weight 186.207, symbol Re.		2.0210manganese group element atom
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0510copper group element atom;
elemental silver		Escherichia coli metabolite
gallocatechol
(-)-epigallocatechin : A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration.		2.3110catechin;
flavan-3,3',4',5,5',7-hexol		antioxidant;
food component;
plant metabolite
propargylamine
propargylamine: RN given refers to parent cpd; structure		2.4420
pentachloropseudilin
pentachloropseudilin: structure in first source		3.0140
blister
blebbistatin: structure in first source. blebbistatin : A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II.		2.1110cyclic ketone;
pyrroloquinoline;
tertiary alcohol;
tertiary alpha-hydroxy ketone		inhibitor
quercetin
[no description available]		2.31107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol
[no description available]		2.31107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
blebbistatin
(S)-blebbistatin : The (S)-enantiomer of blebbistatin.		2.3110blebbistatin;
tertiary alpha-hydroxy ketone
cytochalasin b
Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.		2.3110cytochalasin;
lactam;
lactone;
organic heterotricyclic compound		actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.0510
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510
Leukemia L 1210
[description not available]		01.9810
B16 Melanoma
[description not available]		01.9810