Page last updated: 2024-11-11

ginsenoside f1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ginsenoside F1: from ginseng [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ginsenoside F1 : A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
PanaxgenusAn araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).[MeSH]AraliaceaeThe ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).[MeSH]

Cross-References

ID SourceID
PubMed CID9809542
CHEMBL ID584011
CHEBI ID77150
MeSH IDM0155826

Synonyms (20)

Synonym
53963-43-2
ginsenoside f1
CHEMBL584011
chebi:77150 ,
S9299
CS-3842
ginsenosidef1
(beta,6alpha,12beta)-3,6,12-trihydroxydammar-24-en-20-yl beta-d-glucopyranoside
(20s)-ginsenoside f1
C20780
Q-100611
HY-N0598
ginsenoside f1, >=98% (hplc)
20(s)-ginsenoside f1
AKOS037514665
Q27146705
(2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[(2s)-6-methyl-2-[(3s,5r,6s,8r,9r,10r,12r,13r,14r,17s)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triol
DTXSID00968777
CCG-270314
AS-76768

Research Excerpts

Overview

Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenosides Re and Rg1 in Panax ginseng.

ExcerptReferenceRelevance
"Ginsenoside F1 (GF1) is a metabolite of ginsenoside Rg1. "( Role of epidermal γδ T-cell-derived interleukin 13 in the skin-whitening effect of Ginsenoside F1.
Han, J; Kim, E; Kim, K; Kwon, O; Lee, E; Lee, TR; Yeom, MH; Yoon, TH, 2014
)
2.07
"Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. "( Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signalling.
Baek, EJ; Kang, NJ; Kim, JH; Lee, EJ; Lee, KW; Park, JS; Yeom, MH, 2015
)
3.3

Pharmacokinetics

ExcerptReferenceRelevance
"To study the pharmacokinetics of ginsenosides Rg1 and its metabolites after iv and oral administration in Wistar rats, the LC-MS/MS method was selected to determine ginsenosides Rg1 and its metabolites in plasma and their pharmacokinetic parameters were calculated."( [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
Feng, L; Hu, CJ; Yu, LY, 2010
)
0.36

Compound-Compound Interactions

ExcerptReferenceRelevance
"Modulation of drug transporters via herbal medicines which have been widely used in combination with conventional prescription drugs may result in herb-drug interactions in clinical practice."( Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.
Hu, J; Li, X; Li, Y; Liu, Z; Sheng, L; Wang, B; Yang, S, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
apoptosis inhibitorAny substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (7)

ClassDescription
12beta-hydroxy steroid
3beta-hydroxy steroidA 3-hydroxy steroid in which the 3-hydroxy substituent is in the beta-position.
beta-D-glucosideAny D-glucoside in which the anomeric centre has beta-configuration.
ginsenosideTriterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives.
tetracyclic triterpenoidAny triterpenoid consisting of a tetracyclic skeleton.
6alpha-hydroxy steroid
3beta-hydroxy-4,4-dimethylsteroidAny 3beta-hydroxy steroid which is substituted by two methyl groups at position 4.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
ginsenosides biosynthesis1032

Bioassays (9)

Assay IDTitleYearJournalArticle
AID455592Inhibition of ultraviolet-B-induced apoptosis in human HaCaT cells2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.
AID455590Induction of apoptosis in human HL60 cells assessed as DNA accumulation at sub-G1 phase at IC50 concentration after 24 hrs by flow cytometry2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.
AID455589Cytotoxicity against human HL60 cells by MTT assay2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.
AID1370961Activation of SIRT1 (unknown origin) assessed as Fluor de Lys deacetylation at 10 to 20 uM incubated for 5 mins followed by substrate addition measured after 45 mins in presence of NAD/NADH by fluorescence assay2018Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng.
AID1172639Inhibition of cell proliferation of human U251 cells assessed as cell viability at 100 uM after 72 hrs by sulforhodamine B assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Bioactive triterpenoid saponins and phenolic compounds against glioma cells.
AID1317165Activation of recombinant human SIRT1 using TPE-GK(Ac)YDD as substrate at 50 uM by fluorescence assay relative to control2016European journal of medicinal chemistry, Aug-25, Volume: 119How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
AID1370960Inhibition of SIRT1 (unknown origin) assessed as reduction in Fluor de Lys deacetylation at 10 to 20 uM incubated for 5 mins followed by substrate addition measured after 45 mins in presence of NAD/NADH by fluorescence assay2018Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng.
AID1172640Inhibition of cell proliferation of rat C6 cells assessed as cell viability at 100 uM after 72 hrs by sulforhodamine B assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Bioactive triterpenoid saponins and phenolic compounds against glioma cells.
AID455591Induction of apoptosis in human HL60 cells assessed as increase of apoptotic bodies at IC50 concentration after 24 hrs using Hoechst 33342 staining by fluorescent microscopic analysis2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (3.13)18.7374
1990's0 (0.00)18.2507
2000's6 (18.75)29.6817
2010's22 (68.75)24.3611
2020's3 (9.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.01 (24.57)
Research Supply Index3.50 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (19.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]