Compounds > 2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
Page last updated: 2024-09-27

2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one

Description

2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one : A trimethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6 and 7 and a hydroxy group at position 4'. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID243759
CHEMBL ID74490
CHEBI ID79510
SCHEMBL ID735537

Synonyms (21)

Synonym
CHEMBL74490 ,
chebi:79510 ,
nsc53906
6938-18-7
nsc-53906
NCI60_004327
4'-hydroxy-5,6,7-trimethoxyflavone
2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4h-1-benzopyran-4-one
4h-1-benzopyran-4-one, 2-(4-hydroxyphenyl)-5,6,7-trimethoxy-
2-(4-hydroxyphenyl)-5,6,7-trimethoxy-chromen-4-one
bdbm50064136
2-(4-hydroxyphenyl)-5,6,7-trimethoxychromen-4-one
unii-ok09yo2bp5
ok09yo2bp5 ,
nsc 53906
SCHEMBL735537
2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4h-chromen-4-one
DTXSID40219472
PJRWXHDCKWSIRU-UHFFFAOYSA-N
Q27148597
flavone, 4'-hydroxy-5,6,7-trimethoxy-

Drug Classes (2)

ClassDescription
trimethoxyflavoneA methoxyflavone that is flavone substituted by three methoxy groups.
monohydroxyflavoneA hydroxyflavone carrying a single hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50 (µMol)100.00000.00000.94539.9400AID1193209
AcetylcholinesteraseRattus norvegicus (Norway rat)IC50 (µMol)300.00000.00020.52597.2000AID1192720; AID1484814
CholinesteraseEquus caballus (horse)IC50 (µMol)100.00000.00002.22149.4000AID1193211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1193211Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman spectrophotometric method2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1484831Metal chelating activity assessed as inhibition of Cu2+ induced amyloid beta (1 to 42) aggregation at 25 uM after 24 hrs by ThT-based fluorometric method relative to control2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID404008Cytotoxicity against human KB cells
AID1484818Antioxidant activity assessed as trolox equivalents of AAPH radical scavenging activity at 1 to 10 uM preincubated for 15 mins followed by AAPH addition measured every 60 sec for 90 mins by ORAC-FL assay2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1192721Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman method2015Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
AID404069In vivo antitumor activity against mouse L1210 cells
AID1484832Metal chelating activity assessed as disaggregation of Cu2+ induced amyloid beta (1 to 42) fibrils at 25 uM treated for 24 hrs post Cu2+ treatment for 24 hrs by ThT-based fluorometric method relative to control2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1193209Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman spectrophotometric method2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1484819Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1484814Inhibition of rat cortex homogenate AChE using acetylthiocholine iodide as substrate after 15 mins in presence of BuChE inhibitor iso-OMPA by Ellman's method2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1192729Neuroprotective effect against H2O2-induced rat PC12 cell injury assessed as cell viability at 10 uM incubated for 2 hrs prior to H2O2 challenge measured after 24 hrs by MTT assay (Rvb = 57.6%)2015Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
AID144650In vitro cytotoxic potency against NCI-60 human tumor cell line1998Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
AID1484815Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's method2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1192728Antioxidant activity assessed as trolox equivalent of APPH-induced radical scavenging activity by ORAC-FL method2015Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
AID1193214Inhibition of self-induced Abeta(1 to 42) (unknown origin) aggregation at 25 uM after 24 hrs by Thioflavin T-based fluorometric assay2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1192720Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method2015Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
AID1484816Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1193213Antioxidant activity assessed as Trolox equivalent per microM of compound after 15 mins by oxygen radical absorbance capacity fluorescein assay2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
AID404067In vivo antitumor activity against mouse S180 cells
AID1484828Inhibition of human erythrocyte AChE induced amyloid beta (1 to 40) aggregation at 100 uM after 24 hrs by ThT-based fluorometric method relative to control2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1193210Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman spectrophotometric method2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
AID1484826Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation at 25 uM after 24 hrs by ThT-based fluorometric method relative to control2017European journal of medicinal chemistry, Jul-28, Volume: 135Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
AID404070In vivo antitumor activity against mouse CA-755 cells
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
taxifolin[no description available]medium103'-hydroxyflavanones;
4'-hydroxyflavanones;
dihydroflavonols;
pentahydroxyflavanone;
secondary alpha-hydroxy ketone
flavanone[no description available]medium10flavanones
hesperidin[no description available]medium103'-hydroxyflavanones;
4'-methoxyflavanones;
dihydroxyflavanone;
disaccharide derivative;
flavanone glycoside;
monomethoxyflavanone;
rutinoside		mutagen
flavone[no description available]medium10flavonesmetabolite;
nematicide
3-hydroxyflavone[no description available]medium10flavonols;
monohydroxyflavone
quercetin pentaacetate[no description available]medium10
pinocembrin[no description available]medium10(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
tangeretin[no description available]medium20pentamethoxyflavoneantineoplastic agent;
plant metabolite
5-hydroxyflavone[no description available]medium10flavones
6-hydroxyflavone[no description available]medium10hydroxyflavonoid
hesperetin[no description available]medium103'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite
isoflavone[no description available]medium10isoflavones
nobiletin[no description available]medium20methoxyflavoneantineoplastic agent;
plant metabolite
4',5,6,7-tetramethoxyflavone[no description available]medium20tetramethoxyflavoneantimutagen;
plant metabolite
quercetin 5,7,3',4'-tetramethyl ether[no description available]medium20flavonols;
tetramethoxyflavone		plant metabolite
3,5,7,3',4'-pentamethoxyflavone[no description available]medium10
6-methoxyflavanone[no description available]medium10
4'-methoxyflavanone[no description available]medium104'-methoxyflavanones
4'-hydroxyflavone[no description available]medium10
nsc 36398[no description available]medium10
7-Acetoxy-2-methylisoflavone[no description available]medium10isoflavones
Poriol[no description available]medium10flavanones
sakuranetin[no description available]medium10
naringenin[no description available]medium10(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
flavoxate hydrochloride[no description available]medium10hydrochlorideantispasmodic drug;
muscarinic antagonist;
parasympatholytic
quercetin[no description available]medium207-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
biochanin a[no description available]medium104'-methoxyisoflavones;
7-hydroxyisoflavones		antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
formononetin[no description available]medium104'-methoxyisoflavones;
7-hydroxyisoflavones		phytoestrogen;
plant metabolite
acacetin[no description available]medium10dihydroxyflavone;
monomethoxyflavone		anticonvulsant;
plant metabolite
apigenin[no description available]medium10trihydroxyflavoneantineoplastic agent;
metabolite
quercetin 3-o-methyl ether[no description available]medium10monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite
apigetrin[no description available]medium10beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative		antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug
quercetin 3-o-glucopyranoside[no description available]medium10beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
rutin[no description available]medium10disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
apigenin dimethylether[no description available]medium10dimethoxyflavone;
monohydroxyflavone		plant metabolite
chrysin[no description available]medium107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fisetin[no description available]medium203'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
galangin[no description available]medium107-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
hispidulin[no description available]medium20monomethoxyflavone;
trihydroxyflavone		anti-inflammatory agent;
anticonvulsant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite
kaempferide[no description available]medium107-hydroxyflavonol;
monomethoxyflavone;
trihydroxyflavone		antihypertensive agent;
metabolite
morin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
myricetin[no description available]medium207-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
myricitrin[no description available]medium10alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone		anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
norwogonin[no description available]medium10trihydroxyflavoneantioxidant;
metabolite
orientin[no description available]medium103'-hydroxyflavonoid;
C-glycosyl compound;
tetrahydroxyflavone		antioxidant;
metabolite
pachypodol[no description available]medium10dihydroxyflavone;
trimethoxyflavone		antiemetic;
plant metabolite
rhamnetin[no description available]medium20monomethoxyflavone;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
metabolite
robinetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		plant metabolite
psi-baptigenin[no description available]medium107-hydroxyisoflavones;
benzodioxoles		antiprotozoal drug;
plant metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
tectochrysin[no description available]medium10monohydroxyflavone;
monomethoxyflavone		antidiarrhoeal drug;
antineoplastic agent;
plant metabolite
quercimeritrin[no description available]medium10beta-D-glucoside;
flavonols;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antioxidant;
metabolite
centaureidin[no description available]medium20trihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
plant metabolite
5,7-dihydroxy-4',6-dimethoxyflavone[no description available]medium20dihydroxyflavone;
dimethoxyflavone		plant metabolite
ermanin[no description available]medium20dihydroxyflavone;
dimethoxyflavone		anti-inflammatory agent;
antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
plant metabolite
5-hydroxy-3,3',4',7-tetramethoxyflavone[no description available]medium203'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone		plant metabolite
3',4',5'-O-trimethyltricetin[no description available]medium103',5'-dimethoxyflavone;
dihydroxyflavone;
trimethoxyflavone
5,7,3'-trihydroxy-3,4'-dimethoxyflavone[no description available]medium20dimethoxyflavone;
trihydroxyflavone		antineoplastic agent;
metabolite
7-Hydroxy-2-methylisoflavone[no description available]medium10isoflavones
colchicine[no description available]medium10alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
podophyllotoxin[no description available]medium10furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
5,4'-dihydroxy-3,6,7,8,3'-pentamethoxyflavone[no description available]medium10
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone[no description available]medium10ether;
flavonoids
3,3',4',5,6,7,8-heptamethoxyflavone[no description available]medium10ether;
flavonoids
sideritoflavone[no description available]medium10ether;
flavonoids
nevadensin[no description available]medium10dihydroxyflavone;
trimethoxyflavone		plant metabolite
4',5-dihydroxy-3',6,7,8-tetramethoxyflavone[no description available]medium10
4',6-dihydroxy-5,7-dimethoxyflavone[no description available]medium10dihydroxyflavone;
dimethoxyflavone
gardenin a[no description available]medium10
3',4',5'-trimethoxyflavone[no description available]medium10ether;
flavonoids
5-demethylnobiletin[no description available]medium10ether;
flavonoids
5-Hydroxy-7-methoxy-6-methylflavone[no description available]medium10ether;
flavonoids
5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone[no description available]medium10
eupatilin[no description available]medium10dihydroxyflavone;
trimethoxyflavone		anti-inflammatory agent;
anti-ulcer drug;
antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
metabolite
ayanin[no description available]medium10dihydroxyflavone;
trimethoxyflavone		plant metabolite
chrysosplenetin b[no description available]medium10dihydroxyflavone;
tetramethoxyflavone		antiviral agent;
plant metabolite
eupatin[no description available]medium10flavonols;
trihydroxyflavone;
trimethoxyflavone
ombuine[no description available]medium10dimethoxyflavone;
flavonols;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
ternatin (flavonoid)[no description available]medium10ether;
flavonoids
theophylline[no description available]medium10dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
verapamil[no description available]medium10aromatic ether;
nitrile;
polyether;
tertiary amino compound
clonidine[no description available]medium10clonidine;
imidazoline
diazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
enoxacin[no description available]medium101,8-naphthyridine derivative;
amino acid;
fluoroquinolone antibiotic;
monocarboxylic acid;
N-arylpiperazine;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
norfloxacin[no description available]medium10fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
oxazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic
rivastigmine[no description available]medium10carbamate ester;
tertiary amino compound		cholinergic drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
neuroprotective agent
cirsimaritin[no description available]medium20dihydroxyflavone;
dimethoxyflavone
piroxicam[no description available]medium10benzothiazine;
monocarboxylic acid amide;
pyridines		analgesic;
antirheumatic drug;
cyclooxygenase 1 inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
6-chlorotacrine[no description available]medium10
donepezil[no description available]medium10aromatic ether;
indanones;
piperidines;
racemate		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
nootropic agent
curcumin[no description available]medium10aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
xanthomicrol[no description available]low00dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite
eupatorin[no description available]low00dihydroxyflavone;
polyphenol;
trimethoxyflavone		anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
Brassica napus metabolite;
calcium channel blocker;
P450 inhibitor;
vasodilator agent
salvigenin[no description available]low00monohydroxyflavone;
trimethoxyflavone		antilipemic drug;
antineoplastic agent;
apoptosis inhibitor;
autophagy inducer;
hypoglycemic agent;
immunomodulator;
neuroprotective agent;
plant metabolite
cirsilineol[no description available]low00dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite
chrysosplenol c[no description available]low00trihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
antiviral agent;
plant metabolite
5,6,7-trimethoxyflavone[no description available]low00trimethoxyflavoneanti-HSV-1 agent;
plant metabolite
dexmedetomidine[no description available]low00trihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
metabolite
santin[no description available]low00dihydroxyflavone;
trimethoxyflavone		plant metabolite
gardenin b[no description available]low00monohydroxyflavone;
tetramethoxyflavone		plant metabolite
wogonoside[no description available]low00beta-D-glucosiduronic acid;
glycosyloxyflavone;
monohydroxyflavone;
monomethoxyflavone;
monosaccharide derivative
oroxylin a-7-o-glucuronide[no description available]low00beta-D-glucosiduronic acid;
glycosyloxyflavone;
monohydroxyflavone;
monomethoxyflavone;
monosaccharide derivative		plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia0low30
Alzheimer Dementia0low30
Alzheimer Disease0low30
Alzheimer Disease, Early Onset0low30
Alzheimer Disease, Late Onset0low30
Alzheimer Sclerosis0low30
Alzheimer Syndrome0low30
Alzheimer Type Senile Dementia0low30
Alzheimer-Type Dementia (ATD)0low30
Alzheimer's Disease0low30
Alzheimer's Disease, Focal Onset0low30
Alzheimer's Diseases0low30
Dementia, Alzheimer Type0low30
Dementia, Presenile0low30
Dementia, Primary Senile Degenerative0low30
Dementia, Senile0low30
Early Onset Alzheimer Disease0low30
Familial Alzheimer Disease (FAD)0low30
Focal Onset Alzheimer's Disease0low30
Late Onset Alzheimer Disease0low30
Presenile Alzheimer Dementia0low30
Primary Senile Degenerative Dementia0low30
Senile Dementia, Acute Confusional0low30
Senile Dementia, Alzheimer Type0low30

Research Highlights

Safety/Toxicity (1)

ArticleYear
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
Journal of medicinal chemistry, Jun-18, Volume: 41, Issue: 13		1998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]