(E)-1,7-Bis(4-hydroxyphenyl)hept-4-en-3-one : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 23786382 |
| CHEMBL ID | 330645 |
| CHEBI ID | 182667 |
| Synonym |
|---|
| (e)-1,7-bis(4-hydroxyphenyl)hept-4-en-3-one |
| CHEBI:182667 |
| MEGXP0_000308 |
| platyphyllenone |
| CHEMBL330645 |
| 56973-65-0 |
| 1,7-bis(4-hydroxyphenyl)-4-hepten-3-one, >=95% (lc/ms-elsd) |
| AKOS032948799 |
| 1,7-bis(4-hydroxyphenyl)-4-hepten-3-one |
| DTXSID301346755 |
| platyphyllene |
| AKOS040762208 |
| FS-10027 |
| CS-0023079 |
| HY-N3043 |
| Class | Description |
|---|---|
| diarylheptanoid | A family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species. |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID466922 | Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| AID480667 | Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 10 uM after 20 mins by microplate reader assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 ISSN: 1464-3405 | Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells. |
| AID1607890 | Inhibition of COX2 (unknown origin) at 10 mM using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 2 mins by ELISA relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179ISSN: 1768-3254 | Human disorders associated with inflammation and the evolving role of natural products to overcome. |
| AID738071 | Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 50 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 ISSN: 1464-3405 | Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells. |
| AID738070 | Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 100 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 ISSN: 1464-3405 | Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells. |
| AID182177 | Compound was tested for O2- scavenging activity using NBT method at a concentration of 20 ug/mL. | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 ISSN: 0960-894X | Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica. |
| AID466919 | Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei B48 after 48 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| AID738072 | Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 10 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 ISSN: 1464-3405 | Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells. |
| AID480668 | Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 100 uM after 20 mins by microplate reader assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 ISSN: 1464-3405 | Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells. |
| AID597201 | Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 ISSN: 1464-3405 | Antifibrotic constituents of Alnus firma on hepatic stellate cells. |
| AID461108 | Antiviral activity against Influenza A virus (A/Korea/KBNP-0028/2000(H9N2)) infected in chicken egg after 5 days by hemagglutinination assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 ISSN: 1464-3405 | Anti-influenza diarylheptanoids from the bark of Alnus japonica. |
| AID466917 | Antitrypanosomal activity against Trypanosoma brucei brucei 427 after 48 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| AID182346 | Compound was tested for antioxidative activity using TBA method at a concentration of 200 ug/mL. | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 ISSN: 0960-894X | Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica. |
| AID461110 | Cytotoxicity against CEF cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 ISSN: 1464-3405 | Anti-influenza diarylheptanoids from the bark of Alnus japonica. |
| AID738069 | Inhibition of differentiation of mouse 3T3L1 cells assessed as reduction of lipid accumulation after 8 days by using Oil Red O staining by spectrophotometry relative to control | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 ISSN: 1464-3405 | Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells. |
| AID466918 | Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei deltaTbat1-KO after 48 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| AID466921 | Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 amastigotes after 48 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| AID461109 | Selectivity index, ratio of CC50 for CEF cells to EC50 for Influenza A virus (A/Korea/KBNP-0028/2000(H9N2)) | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 ISSN: 1464-3405 | Anti-influenza diarylheptanoids from the bark of Alnus japonica. |
| AID466920 | Antileishmanial activity against Leishmania major Friedlin promastigotes after 48 hrs by alamar blue assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 ISSN: 1768-3254 | Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arthritis, Rheumatoid | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Benign Neoplasms | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Cardiovascular Diseases | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Cirrhosis, Liver | 0 | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Dermatoses | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Inflammation | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Innate Inflammatory Response | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Liver Cirrhosis | 0 | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Neoplasms | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Rheumatoid Arthritis | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Skin Diseases | 0 | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |