positive regulation of cell migration

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]

Positive regulation of cell migration is a complex biological process involving the coordinated action of multiple signaling pathways, cytoskeletal rearrangements, and adhesion molecules. This intricate interplay enables cells to move in response to various stimuli, including growth factors, chemokines, and mechanical cues. The process begins with the reception of external signals, such as chemokines, by specific cell surface receptors. These signals trigger intracellular signaling cascades, primarily involving small GTPases like Rho, Rac, and Cdc42, as well as protein kinases like MAPK and PI3K. These signaling pathways activate downstream effectors, leading to cytoskeletal rearrangements. Actin polymerization and depolymerization, regulated by actin-binding proteins and Rho GTPases, drive protrusion formation at the leading edge of migrating cells. Meanwhile, focal adhesion complexes, composed of integrins and associated proteins, provide the anchor points for cells to adhere to the extracellular matrix and generate traction forces. These forces are essential for cell movement. Concurrently, the rear of the cell detaches from the substrate through the disassembly of focal adhesions. This detachment facilitates retraction of the trailing edge and allows the cell to move forward. The entire process is highly regulated, ensuring precise coordination of protrusive, adhesive, and retractive forces. Any disruption of these delicate balances can lead to aberrant cell migration, contributing to various disease states, including cancer metastasis and inflammatory disorders.'
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Proteins (79)

Compounds (2,768)