Page last updated: 2024-12-08

cirsiliol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cirsiliol: potent inhibitor of arachidonate lipooxygenase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cirsiliol : A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID160237
CHEMBL ID72637
CHEBI ID3719
SCHEMBL ID1614677
MeSH IDM0118974

Synonyms (34)

Synonym
34334-69-5
cirsiliol
CHEMBL72637 ,
chebi:3719 ,
LMPK12111227
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4h-chromen-4-one
5,3'',4''-trihydroxy-6,7-dimethoxyflavone
bdbm50025321
2-(3,4-dihydroxy-phenyl)-5-hydroxy-6,7-dimethoxy-chromen-4-one
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one
3',4',5-trihydroxy-6,7-dimethoxy-flavone
3',4',5-trihydroxy-6,7-dimethoxyflavone
6,7-dimethoxy-5,3',4'-trihydroxyflavone
unii-8w4y5jk3xe
4h-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-
8w4y5jk3xe ,
FT-0620861
SCHEMBL1614677
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4h-1-benzopyran-4-one
5,3',4'-trihydroxy-6,7-dimethoxyflavone
6-methoxyluteolin 7-methyl ether
6,7-dimethoxy-3',4',5-trihydroxyflavone
AKOS025287589
DTXSID60187907
mfcd00210577
CS-0040434
HY-110399
6,7-dimethoxy-5',3',4'-trihydroxyflavone
6-hydroxyluteolin-6,7-dimethyl ether; 6-methoxyluteolin 7-methyl ether; crisiliol
BCP28925
Q27106177
MS-24955
E80755
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-chromen-4-one

Research Excerpts

Actions

ExcerptReferenceRelevance
"Cirsiliol could inhibit ESCC growth in vitro and in vivo."( Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo.
Chen, H; Dong, Z; Hu, Y; Huang, C; Jia, X; Li, X; Liu, F; Liu, K; Nie, W; Wu, Q, 2021
)
2.79
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
trihydroxyflavoneAny hydroxyflavone carrying three hydroxy groups at unspecified positions.
dimethoxyflavoneAny methoxyflavone with two methoxy substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 1A1Homo sapiens (human)Ki0.80000.01200.94693.8000AID598341
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC50 (µMol)0.16980.00041.877310.0000AID342547
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC50 (µMol)0.09500.00462.018210.0000AID6806
Cytochrome P450 1B1Homo sapiens (human)Ki0.80000.00300.97417.4600AID598342
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (88)

Processvia Protein(s)Taxonomy
cellular response to organic cyclic compoundCytochrome P450 1A1Homo sapiens (human)
response to hypoxiaCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid metabolic processCytochrome P450 1A1Homo sapiens (human)
lipid hydroxylationCytochrome P450 1A1Homo sapiens (human)
fatty acid metabolic processCytochrome P450 1A1Homo sapiens (human)
steroid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
porphyrin-containing compound metabolic processCytochrome P450 1A1Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 1A1Homo sapiens (human)
steroid metabolic processCytochrome P450 1A1Homo sapiens (human)
estrogen metabolic processCytochrome P450 1A1Homo sapiens (human)
amine metabolic processCytochrome P450 1A1Homo sapiens (human)
response to nematodeCytochrome P450 1A1Homo sapiens (human)
response to herbicideCytochrome P450 1A1Homo sapiens (human)
ethylene metabolic processCytochrome P450 1A1Homo sapiens (human)
coumarin metabolic processCytochrome P450 1A1Homo sapiens (human)
flavonoid metabolic processCytochrome P450 1A1Homo sapiens (human)
response to iron(III) ionCytochrome P450 1A1Homo sapiens (human)
insecticide metabolic processCytochrome P450 1A1Homo sapiens (human)
dibenzo-p-dioxin catabolic processCytochrome P450 1A1Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 1A1Homo sapiens (human)
response to foodCytochrome P450 1A1Homo sapiens (human)
response to lipopolysaccharideCytochrome P450 1A1Homo sapiens (human)
response to vitamin ACytochrome P450 1A1Homo sapiens (human)
response to immobilization stressCytochrome P450 1A1Homo sapiens (human)
vitamin D metabolic processCytochrome P450 1A1Homo sapiens (human)
retinol metabolic processCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
9-cis-retinoic acid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
camera-type eye developmentCytochrome P450 1A1Homo sapiens (human)
nitric oxide metabolic processCytochrome P450 1A1Homo sapiens (human)
response to arsenic-containing substanceCytochrome P450 1A1Homo sapiens (human)
digestive tract developmentCytochrome P450 1A1Homo sapiens (human)
tissue remodelingCytochrome P450 1A1Homo sapiens (human)
hydrogen peroxide biosynthetic processCytochrome P450 1A1Homo sapiens (human)
response to hyperoxiaCytochrome P450 1A1Homo sapiens (human)
maternal process involved in parturitionCytochrome P450 1A1Homo sapiens (human)
hepatocyte differentiationCytochrome P450 1A1Homo sapiens (human)
cellular response to copper ionCytochrome P450 1A1Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 1A1Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleCytochrome P450 1A1Homo sapiens (human)
response to 3-methylcholanthreneCytochrome P450 1A1Homo sapiens (human)
cellular response to organic cyclic compoundCytochrome P450 1B1Homo sapiens (human)
angiogenesisCytochrome P450 1B1Homo sapiens (human)
trabecular meshwork developmentCytochrome P450 1B1Homo sapiens (human)
DNA modificationCytochrome P450 1B1Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 1B1Homo sapiens (human)
nitric oxide biosynthetic processCytochrome P450 1B1Homo sapiens (human)
cell adhesionCytochrome P450 1B1Homo sapiens (human)
response to nutrientCytochrome P450 1B1Homo sapiens (human)
steroid metabolic processCytochrome P450 1B1Homo sapiens (human)
estrogen metabolic processCytochrome P450 1B1Homo sapiens (human)
negative regulation of cell population proliferationCytochrome P450 1B1Homo sapiens (human)
male gonad developmentCytochrome P450 1B1Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stressCytochrome P450 1B1Homo sapiens (human)
toxin metabolic processCytochrome P450 1B1Homo sapiens (human)
positive regulation of vascular endothelial growth factor productionCytochrome P450 1B1Homo sapiens (human)
positive regulation of smooth muscle cell migrationCytochrome P450 1B1Homo sapiens (human)
sterol metabolic processCytochrome P450 1B1Homo sapiens (human)
arachidonic acid metabolic processCytochrome P450 1B1Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 1B1Homo sapiens (human)
collagen fibril organizationCytochrome P450 1B1Homo sapiens (human)
adrenal gland developmentCytochrome P450 1B1Homo sapiens (human)
negative regulation of cell migrationCytochrome P450 1B1Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activityCytochrome P450 1B1Homo sapiens (human)
response to follicle-stimulating hormoneCytochrome P450 1B1Homo sapiens (human)
response to estradiolCytochrome P450 1B1Homo sapiens (human)
negative regulation of cell adhesion mediated by integrinCytochrome P450 1B1Homo sapiens (human)
benzene-containing compound metabolic processCytochrome P450 1B1Homo sapiens (human)
retinol metabolic processCytochrome P450 1B1Homo sapiens (human)
retinal metabolic processCytochrome P450 1B1Homo sapiens (human)
positive regulation of apoptotic processCytochrome P450 1B1Homo sapiens (human)
blood vessel endothelial cell migrationCytochrome P450 1B1Homo sapiens (human)
endothelial cell migrationCytochrome P450 1B1Homo sapiens (human)
estrous cycleCytochrome P450 1B1Homo sapiens (human)
positive regulation of translationCytochrome P450 1B1Homo sapiens (human)
positive regulation of angiogenesisCytochrome P450 1B1Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STATCytochrome P450 1B1Homo sapiens (human)
membrane lipid catabolic processCytochrome P450 1B1Homo sapiens (human)
response to arsenic-containing substanceCytochrome P450 1B1Homo sapiens (human)
blood vessel morphogenesisCytochrome P450 1B1Homo sapiens (human)
retinal blood vessel morphogenesisCytochrome P450 1B1Homo sapiens (human)
ganglion developmentCytochrome P450 1B1Homo sapiens (human)
cellular response to hydrogen peroxideCytochrome P450 1B1Homo sapiens (human)
cellular response to cAMPCytochrome P450 1B1Homo sapiens (human)
cellular response to tumor necrosis factorCytochrome P450 1B1Homo sapiens (human)
cellular response to luteinizing hormone stimulusCytochrome P450 1B1Homo sapiens (human)
cellular response to cortisol stimulusCytochrome P450 1B1Homo sapiens (human)
cellular response to progesterone stimulusCytochrome P450 1B1Homo sapiens (human)
response to dexamethasoneCytochrome P450 1B1Homo sapiens (human)
endothelial cell-cell adhesionCytochrome P450 1B1Homo sapiens (human)
response to indole-3-methanolCytochrome P450 1B1Homo sapiens (human)
cellular response to toxic substanceCytochrome P450 1B1Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 1B1Homo sapiens (human)
response to 3-methylcholanthreneCytochrome P450 1B1Homo sapiens (human)
regulation of reactive oxygen species metabolic processCytochrome P450 1B1Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCytochrome P450 1B1Homo sapiens (human)
positive regulation of DNA biosynthetic processCytochrome P450 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (22)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
iron ion bindingCytochrome P450 1A1Homo sapiens (human)
protein bindingCytochrome P450 1A1Homo sapiens (human)
arachidonic acid monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
oxidoreductase activityCytochrome P450 1A1Homo sapiens (human)
oxidoreductase activity, acting on diphenols and related substances as donorsCytochrome P450 1A1Homo sapiens (human)
flavonoid 3'-monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
oxygen bindingCytochrome P450 1A1Homo sapiens (human)
enzyme bindingCytochrome P450 1A1Homo sapiens (human)
heme bindingCytochrome P450 1A1Homo sapiens (human)
Hsp70 protein bindingCytochrome P450 1A1Homo sapiens (human)
demethylase activityCytochrome P450 1A1Homo sapiens (human)
Hsp90 protein bindingCytochrome P450 1A1Homo sapiens (human)
aromatase activityCytochrome P450 1A1Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid omega-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid omega-1 hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
monooxygenase activityCytochrome P450 1B1Homo sapiens (human)
iron ion bindingCytochrome P450 1B1Homo sapiens (human)
protein bindingCytochrome P450 1B1Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 1B1Homo sapiens (human)
heme bindingCytochrome P450 1B1Homo sapiens (human)
aromatase activityCytochrome P450 1B1Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 1B1Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityCytochrome P450 1B1Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenCytochrome P450 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
mitochondrial inner membraneCytochrome P450 1A1Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 1A1Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A1Homo sapiens (human)
mitochondrionCytochrome P450 1B1Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 1B1Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID598380Activation factor, ratio of IC50 for non-CYP1 expressing human MCF10A to IC50 for CYP1 expressing human MDA-MB-468 cells2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
AID598342Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
AID598341Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
AID1590057Inhibition of IL-6-induced gp130 phosphorylation in human U266 cells at 10 and 20 uM pre-incubated for 1 hr before IL-6 stimulation for 10 to 15 mins by Western blot analysis2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1176794Inhibition of biofilm formation in Staphylococcus aureus AH133 transformed with GFP assessed as reduction in recovery of CFU at 80 ug/disc after 24 hrs by confocal laser scanning microscopy2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
AID1590054Inhibition of IL-6-induced pSTAT3 nuclear translocation in human Hep3B cells at 10 and 20 uM pre-incubated for 1 hr before IL-6 stimulation for 30 mins by DAPI staining based immunofluorescence microscopy2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID467949Antiproliferative activity in human MCF7 cells after 96 hrs by MTT assay in presence of acacetin2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID598381Activity at CYP1A1 in microsomes of human MDA-MB468 cells assessed as parent compound remaining after 20 mins by HPLC analysis2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
AID467947Induction of CYP1B1 expression in human MCF7 cells at 5 uM after 24 hrs by RT PCR2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID1590058Inhibition of IL-6-induced JAK2 phosphorylation at Tyr1007/1008 residues in human U266 cells at 10 and 20 uM pre-incubated for 1 hr before IL-6 stimulation for 10 to 15 mins by Western blot analysis2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID467943Induction of CYP1A1 expression in human MCF7 cells at 2.5 uM after 24 hrs by RT PCR2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID1590051Inhibition of IL-6-induced IL-1beta gene expression in human Hep3B cells pre-incubated for 1 hr before IL-6 stimulation for 6 hrs by RT-PCR method2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID338974Inhibition of cow milk xanthine oxidase at 50 ug/mL
AID1176793Inhibition of biofilm formation in Staphylococcus aureus AH133 transformed with GFP assessed as zone of inhibition at 40 to 80 ug/disc after 24 hrs by confocal laser scanning microscopy2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
AID1546553Growth inhibition of human IGROV1 cells assessed as reduction in cell viability at 15 uM by MTT assay relative to control2020Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
Artemisia: a promising plant for the treatment of cancer.
AID6806Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.1986Journal of medicinal chemistry, Nov, Volume: 29, Issue:11
Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.
AID467946Induction of CYP1A1 expression in human MCF7 cells at 5 uM after 24 hrs by RT PCR2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID1590059Inhibition of IL-6-induced ERK phosphorylation at Tyr202/204 residues in human U266 cells at 10 to 20 uM pre-incubated for 1 hr before IL-6 stimulation for 10 to 15 mins by Western blot analysis2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1546554Growth inhibition of human OVCAR3 cells assessed as reduction in cell viability at 15 uM by MTT assay relative to control2020Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
Artemisia: a promising plant for the treatment of cancer.
AID1590060Inhibition of IL-6 binding to human recombinant soluble IL-6R incubated for 2 hrs by solid phase ligand binding assay2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID467945Induction of CYP1B1 expression in human MCF7 cells at 1.25 uM after 24 hrs by RT PCR2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID1590048Cytotoxicity against human Hep3B cells assessed as cell viability at 1 to 20 uM incubated for 24 hrs by MTT assay2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1590050Inhibition of IL-6-induced CRP gene expression in human Hep3B cells pre-incubated for 1 hr before IL-6 stimulation for 6 hrs by RT-PCR method2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1590053Inhibition of IL-6-induced SOCS3 gene expression in human Hep3B cells pre-incubated for 1 hr before IL-6 stimulation for 6 hrs by RT-PCR method2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1590049Inhibition of IL6-induced STAT3 phosphorylation in human Hep3B cells incubated for 12 hrs in presence of IL6 by luciferase reporter gene assay2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1590052Inhibition of IL-6-induced ICAM1 gene expression in human Hep3B cells pre-incubated for 1 hr before IL-6 stimulation for 6 hrs by RT-PCR method2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1590055Inhibition of IL-6-induced pSTAT3 nuclear translocation in human U266 cells at 20 uM pre-incubated for 1 hr before IL-6 stimulation for 30 mins by DAPI staining based immunofluorescence microscopy2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID342547Inhibition of rat lens aldose reductase2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
QSAR prediction of inhibition of aldose reductase for flavonoids.
AID1176791Inhibition of biofilm formation in Staphylococcus aureus AH133 transformed with GFP assessed as zone of inhibition at 16 mg/ml after 24 hrs by confocal laser scanning microscopy2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
AID1176792Inhibition of biofilm formation in Staphylococcus aureus AH133 transformed with GFP assessed as zone of inhibition at 10 to 20 ug/disc after 24 hrs by confocal laser scanning microscopy2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
AID467948Antiproliferative activity in human MCF7 cells after 96 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
AID349305Binding affinity to GABAA receptor2008European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
QSAR modeling of the interaction of flavonoids with GABA(A) receptor.
AID1590056Inhibition of IL-6-induced STAT3 phosphorylation at Tyr 705 residue in human U266 cells at 10 to 20 uM pre-incubated for 1 hr before IL-6 stimulation for 15 mins by Western blot analysis2019Bioorganic & medicinal chemistry letters, 07-01, Volume: 29, Issue:13
In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.
AID1546555Growth inhibition of human HCT116 cells assessed as reduction in cell viability at 15 uM by MTT assay relative to control2020Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
Artemisia: a promising plant for the treatment of cancer.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (19.23)18.7374
1990's1 (3.85)18.2507
2000's6 (23.08)29.6817
2010's8 (30.77)24.3611
2020's6 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.57 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index5.26 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other26 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]