1-hexacosanol, also known as ceryl alcohol, is a long-chain fatty alcohol found naturally in various plant and animal sources. It is a white, waxy solid with a melting point around 85-86 °C. Its synthesis involves various methods, including reduction of the corresponding fatty acid or direct extraction from natural sources. Studies have shown that 1-hexacosanol possesses potential biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. It is also known to exhibit skin moisturizing and protective effects, making it a valuable component in cosmetics and personal care products. The compound's ability to interact with cell membranes and its role in plant and animal physiology make it a subject of ongoing research in fields like medicine, agriculture, and biotechnology.'
1-hexacosanol: RN given for parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
hexacosanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of twenty-six carbon atoms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
hexacosan-1-ol : A very long-chain primary fatty alcohol that is hexacosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 68171 |
| CHEBI ID | 28415 |
| SCHEMBL ID | 15830 |
| MeSH ID | M0147664 |
| Synonym |
|---|
| AKOS015839859 |
| cerylic alcohol |
| nsc-4058 |
| n-hexacosanol |
| ceryl alcohol |
| nsc4058 , |
| hexacosyl alcohol |
| CHEBI:28415 , |
| 506-52-5 |
| C08381 |
| 1-hexacosanol |
| hexacosan-1-ol |
| 1-hexacosanol, >=97% (capillary gc) |
| LMFA05000002 |
| H0342 |
| nsc 4058 |
| einecs 208-044-4 |
| m7sd300nnb , |
| unii-m7sd300nnb |
| hexacosanol |
| FT-0607881 |
| hexacosanol (constituent of saw palmetto) [dsc] |
| hexacosanol [usp-rs] |
| SCHEMBL15830 |
| W-105937 |
| mfcd00002940 |
| DTXSID3027162 , |
| hexacosanol, united states pharmacopeia (usp) reference standard |
| 1-hexacosanol, synthetic, >=97.0% (gc) |
| 1-hexacosanol 10 microg/ml in methyl-tert-butyl ether |
| cerylalkohol |
| Q4545790 |
| T72543 |
| CS-0185721 |
| dtxcid507162 |
| hexacosanol (constituent of saw palmetto) |
| hexacosanol (usp-rs) |
| HY-W127493 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The low dosage needed and the peripheral administration of this compound may be of great advantage in the reduction of cell loss in some neurodegenerative disorders like Alzheimer's disease or stroke." | ( Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Borg, J; Cotman, CW; Kesslak, PJ, 1990) | 0.28 |
| "This investigation involved the evaluation of the effect of hexacosanol (HC, ceryl alcohol), a new hydrophobic wax modifier (WM) in comparison with conventional modifiers, on the development of sustained-release allopurinol (AP) solid lipospheres (SLS) intended for use in a suspension formulation and other oral dosage forms." | ( Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation. Abdel-Ghaffar, SK; El-Gibaly, I, 2005) | 0.33 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| insecticide | Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| very long-chain primary fatty alcohol | Any primary fatty alcohol with a chain length between C23 and C27. |
| hexacosanol | A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of twenty-six carbon atoms. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (36.43) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (3.70%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 26 (96.30%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||