| Assay ID | Title | Year | Journal | Article |
|---|
| AID446322 | Inhibition of human HDAC extracted from human HeLa cells at 0.1 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID446323 | Inhibition of human HDAC extracted from human HeLa cells at 1 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID446324 | Inhibition of human HDAC extracted from human HeLa cells at 10 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID7185 | Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. |
| AID732152 | Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID689558 | Antagonist activity at Pseudomonas aeruginosa LasB using Abz-Ala-Gly-Leu-Ala-p-Nitro-Benzyl-Amide as substrate incubated for 30 mins prior to substrate addition by FRET assay | 2012 | ACS medicinal chemistry letters, Aug-09, Volume: 3, Issue:8
| 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
| AID627542 | Cytotoxicity against human PC3 cells | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. |
| AID689561 | Metabolic stability in tryptic soy broth assessed as S-oxidation at 50 uM after 48 hrs | 2012 | ACS medicinal chemistry letters, Aug-09, Volume: 3, Issue:8
| 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
| AID732151 | Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID441921 | Inhibition of Escherichia coli M15 DXR at 100 uM | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID627646 | Cytotoxicity against human MCF7 cells | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. |
| AID6809 | In vitro inhibitory activity against RBL-1 5-LO | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase. |
| AID440465 | Stability in potassium phosphate buffer at pH 7.4 | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Hydroxamates: relationships between structure and plasma stability. |
| AID1439831 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs in presence of salinomycin by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
| Synthesis and biological activity of salinomycin-hydroxamic acid conjugates. |
| AID440466 | Metabolic stability in Sprague-Dawley rat plasma at 10 uM by LC-MS/MS analysis | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Hydroxamates: relationships between structure and plasma stability. |
| AID627544 | Antimicrobial activity against Micrococcus luteus ATCC 10240 after 24 hrs by Kirby-Bauer agar diffusion assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. |
| AID689562 | Metabolic stability in tryptic soy broth assessed as decomposition at 50 uM after 48 hrs | 2012 | ACS medicinal chemistry letters, Aug-09, Volume: 3, Issue:8
| 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
| AID732153 | Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID7184 | In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. |
| AID1439830 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation at 10 uM after 48 hrs in presence of salinomycin by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
| Synthesis and biological activity of salinomycin-hydroxamic acid conjugates. |
| AID732154 | Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID689559 | Antagonist activity at Pseudomonas aeruginosa PA14 LasB assessed as inhibition of swarming at 25 uM after 16 hrs swarming motility assay relative to control | 2012 | ACS medicinal chemistry letters, Aug-09, Volume: 3, Issue:8
| 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID627543 | Cytotoxicity against human HeLa cells | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |