| Assay ID | Title | Year | Journal | Article |
|---|
| AID1230330 | Agonist activity at human delta opioid receptor transfected into HEK293 cells assessed as effect on [35S]-GTPgammaS binding at 300 uM | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID1512118 | Induction of apoptosis in mouse CT26 cells assessed as increase in Bax protein expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512141 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as decrease in CD11b-positive/Gr1-positive myeloid cells level in tumour at 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation flow cytom | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512143 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as increase in infiltration of CD8+ T cells in blood at 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation flow cytometric analysis (Rvb | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1756092 | Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID214172 | In vitro inhibition of binding of [3H]colchicine to tubulin at 50 mM. | 1998 | Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
| Structure-activity requirements for flavone cytotoxicity and binding to tubulin. |
| AID1265079 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1265084 | N-octanol/0.15 M NaCl partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID388894 | Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512135 | Antitumor activity against mouse CT26 cells allografted in Balb/c mouse assessed as inhibition of Ki-67 positive cells in tumour tissue at 25 to 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation by immunohistochemical anal | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1299541 | Inhibition of wild type His-tagged c-KIT (544 to 976 amino acids) (unknown origin) expressed in insect cells using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and subsequent inhibition for 2 hrs by radiome | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2
| Discovery of Dual Inhibitors for Wild Type and D816V Mutant of c-KIT Kinase through Virtual and Biochemical Screening of Natural Products. |
| AID404069 | In vivo antitumor activity against mouse L1210 cells | | | |
| AID1512132 | Antimetastatic activity against ip dosed mouse CT26 cells allografted in Balb/c mouse assessed as reduction in number of tumour nodules administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1230326 | Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) transfected into HEK293 cells at 10 uM by microplate scintillation counting | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID1512133 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as reduction in splenomegaly at 25 to 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512144 | Induction of apoptosis in mouse CT26 cells by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512070 | Induction of apoptosis in mouse CT26 cells by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512127 | Antiinvasive activity against human HCT116 cells after 48 hrs by crystal violet staining based light microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512142 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as increase in infiltration of CD8+ T cells in blood at 25 mg/kg, ip administered daily for 14 days starting from 6 days post implantation flow cytometric analysis (Rvb | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512085 | Induction of apoptosis in human HCT116 cells assessed as nuclear fragmentation up to 40 uM after 48 hrs by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512071 | Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell viability up to 40 uM by MTT assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID144650 | In vitro cytotoxic potency against NCI-60 human tumor cell line | 1998 | Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
| Structure-activity requirements for flavone cytotoxicity and binding to tubulin. |
| AID1512114 | Induction of apoptosis in mouse CT26 cells assessed as decrease in pro-caspase-3 expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512108 | Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.23 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512074 | Anticlonogenic activity against mouse CT26 cells assessed as reduction in colony formation up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512086 | Induction of apoptosis in mouse CT26 cells assessed as nuclear fragmentation up to 40 uM after 48 hrs by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512106 | Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 8.24 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1756090 | Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in Sf9 insect cells incubated for 1 hr by LanthaScreen assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID1756088 | Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID1512073 | Antiproliferative activity against human SW48 cells assessed as reduction in cell viability up to 40 uM by MTT assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1504892 | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. |
| AID388889 | Antiproliferative activity against human Huh-7D12 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID255940 | In vitro inhibitory concentration against human carcinoma COR-L23 cells in the presence of vinblastine sulfate salt | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID1265082 | Aqueous solubility of the compound in water after 1 hr by UV-vis spectrophotometer analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512087 | Induction of apoptosis in mouse CT26 cells assessed as viable cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 88.9 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512080 | Inhibition of colony formation in mouse CT26 cells assessed as reduction in size of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512134 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as reduction in abdominal circumference at 25 to 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388888 | Antiproliferative activity against human 142BR cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512145 | Induction of apoptosis in human HCT116 cells by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512081 | Inhibition of colony formation in human HCT116 cells assessed as reduction in size of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analys | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512090 | Induction of apoptosis in mouse CT26 cells assessed as necrotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.80 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512104 | Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.23 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512122 | Inhibition of cell migration in mouse CT26 cells by microscopy based scratch wound healing assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512123 | Inhibition of cell migration in human HCT116 cells by microscopy based scratch wound healing assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512111 | Induction of apoptosis in human HCT116 cells by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512107 | Induction of apoptosis in human HCT116 cells assessed as viable cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 86.7 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1230329 | Displacement of [3H]-CP55940 from human CB2 receptor transfected into HEK293 cells at 10 uM by microplate scintillation counting | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID1512138 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as decrease in CD11b-positive/Gr1-positive myeloid cells level in peripheral blood at 25 mg/kg, ip administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1756093 | Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID1512093 | Induction of apoptosis in mouse CT26 cells assessed as late apoptotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 6.49 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512121 | Induction of apoptosis in human HCT116 cells assessed increase in Bax/Bcl2 protein ratio up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512103 | Induction of apoptosis in human HCT116 cells assessed as viable cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 86.7 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512078 | Inhibition of colony formation in human HCT116 cells assessed as reduction in number of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic anal | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID214006 | In vitro inhibitory activity against tubulin polymerization (10 uM) | 1998 | Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
| Structure-activity requirements for flavone cytotoxicity and binding to tubulin. |
| AID1504893 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 900 bloodstream forms | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. |
| AID1512088 | Induction of apoptosis in mouse CT26 cells assessed as early apoptotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.84 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512091 | Induction of apoptosis in mouse CT26 cells assessed as viable cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 88.9 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512120 | Induction of apoptosis in mouse CT26 cells assessed as increase in Bax/Bcl2 protein ratio up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512082 | Inhibition of colony formation in human SW48 cells assessed as reduction in size of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID255955 | In vitro inhibitory concentration against human amelanotic melanoma cell line (C32) in the presence of vinblastine sulfate salt | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID1512089 | Induction of apoptosis in mouse CT26 cells assessed as late apoptotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 6.49 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1265081 | Antioxidant activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 25 uM after 4 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512125 | Antimigratory activity against human HCT116 cells assessed as inhibition of cell migration after 48 hrs by crystal violet staining based Boyden-chamber cell migration assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID404008 | Cytotoxicity against human KB cells | | | |
| AID1230327 | Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells by microplate scintillation counting | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID1512130 | Antimetastatic activity against human HCT116 assessed as inhibition of MMP-9 expression after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515531 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production after 48 hrs by ELISA | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1515524 | Cytotoxicity against human PC9 cells after 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1265077 | Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of activated partial thromboplastin time at 100 uM after 3 mins (Rvb = 30.58 +/- 1.55 seconds) | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512110 | Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 8.24 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512075 | Anticlonogenic activity against human HCT116 cells assessed as reduction in colony formation up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512100 | Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.23 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512140 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as decrease in CD11b-positive/Gr1-positive myeloid cells level in tumour at 25 mg/kg, ip administered daily for 14 days starting from 6 days post implantation flow cytom | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515523 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1512112 | Induction of apoptosis in mouse CT26 cells assessed as increase in cleaved caspase-3 expression after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515533 | Inhibition of AChE (unknown origin) at 250 uM using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 secs for 1 hr by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID404068 | In vivo antitumor activity against rat Walker 256 cells | | | |
| AID1512136 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as inhibition of MMP -9 protein expression in tumour tissue at 25 to 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation by immunohistoche | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388890 | Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512139 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as decrease in CD11b-positive/Gr1-positive myeloid cells level in peripheral blood at 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512126 | Antiinvasive activity against mouse CT26 cells after 48 hrs by crystal violet staining based light microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1756091 | Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID1265085 | N-octanol/0.15 M NaHCO3 partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512105 | Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.87 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512146 | Antimetastatic activity against mouse CT26 cells allografted in ip dosed Balb/c mouse assessed as decrease in CD11b-positive/Gr1-positive myeloid cells level in peripheral blood administered daily for 14 days starting from 6 days post implantation by flow | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512098 | Induction of apoptosis in mouse CT26 cells assessed as necrotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.80 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512113 | Induction of apoptosis in human HCT116 cells assessed as increase in cleaved caspase-3 expression after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1230328 | Displacement of [3H]-CP55940 from human CB1 receptor transfected into HEK293 cells at 10 uM by microplate scintillation counting | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID255944 | In vitro inhibitory concentration against human fetal lung MRC-5 cell line in the presence of vinblastine sulfate salt | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID1512124 | Antimigratory activity against mouse CT26 cells assessed as inhibition of cell migration after 48 hrs by crystal violet staining based Boyden-chamber cell migration assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1070435 | Activation of Nrf2 (unknown origin) expressed in CHO-ARE luc cells at 10 to 30 uM after 18 hrs by luciferase reporter gene assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. |
| AID1512102 | Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 8.24 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512094 | Induction of apoptosis in mouse CT26 cells assessed as necrotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.80 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388893 | Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1515532 | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 secs for 1 hr by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1512137 | Antitumor activity against mouse CT26 cells allografted in Balb/c mouse assessed as inhibition of STAT3 phosphorylation in tumour tissue at 25 to 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation by immunohistochemical ana | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388891 | Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512079 | Inhibition of colony formation in human SW48 cells assessed as reduction in number of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analys | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515526 | Immunosuppressive activity in human Jurkat cells assessed as reduction in PHA + PMA-induced IL-2 production at 20 uM after 48 hrs by ELISA | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID404013 | In vivo antitumor activity against mouse P388 cells | | | |
| AID1512115 | Induction of apoptosis in human HCT116 cells assessed as decrease in pro-caspase-3 expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512076 | Anticlonogenic activity against human SW48 cells assessed as reduction in colony formation up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515522 | Cytotoxicity against human NCI-H1975 cells after 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1512131 | Antimetastatic activity against mouse CT26 cells allografted in Balb/c mouse assessed as reduction in weight of tumour nodules weight at 50 mg/kg, ip administered daily for 14 days starting from 6 days post implantation | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1299540 | Inhibition of c-KIT D816V mutant (unknown origin) expressed in HEK293 cells assessed as remaining activity at 100 uM incubated for 1 hr with shaking by qPCR method relative to control | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2
| Discovery of Dual Inhibitors for Wild Type and D816V Mutant of c-KIT Kinase through Virtual and Biochemical Screening of Natural Products. |
| AID1265078 | Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of fibrinogen at 100 uM after 3 mins (Rvb = 7.02+/- 0.16 g/L) | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512092 | Induction of apoptosis in mouse CT26 cells assessed as early apoptotic cells at 20 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.84 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512099 | Induction of apoptosis in human HCT116 cells assessed as viable cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 86.7 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515525 | Immunosuppressive activity in human Jurkat cells assessed as reduction in PHA + PMA-induced IL-2 production after 48 hrs by ELISA | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID1512096 | Induction of apoptosis in mouse CT26 cells assessed as early apoptotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.84 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1299539 | Inhibition of wild type c-KIT (unknown origin) expressed in T7-phage infected Escherichia coli BL21 assessed as remaining activity at 100 uM incubated for 1 hr with shaking by qPCR method relative to control | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2
| Discovery of Dual Inhibitors for Wild Type and D816V Mutant of c-KIT Kinase through Virtual and Biochemical Screening of Natural Products. |
| AID1512095 | Induction of apoptosis in mouse CT26 cells assessed as viable cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 88.9 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1265083 | N-octanol/0.1 M HCl partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1504891 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream forms after 72 hrs by alamar blue staining based fluorescence assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. |
| AID255965 | In vitro inhibitory concentration against human hepatocellular carcinoma HepG-2 cells in the presence of vinblastine sulfate salt; NT: Not tested | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID1299542 | Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and subsequent inhibitio | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2
| Discovery of Dual Inhibitors for Wild Type and D816V Mutant of c-KIT Kinase through Virtual and Biochemical Screening of Natural Products. |
| AID1230324 | Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells at 10 uM by microplate scintillation counting | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6
| Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. |
| AID1265076 | Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of prothrombin time at 100 uM after 3 mins (Rvb = 4.99 +/- 0.18 seconds) | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512097 | Induction of apoptosis in mouse CT26 cells assessed as late apoptotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 6.49 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388892 | Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID404067 | In vivo antitumor activity against mouse S180 cells | | | |
| AID1512116 | Induction of apoptosis in mouse CT26 cells assessed as decrease in Bcl-2 protein expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1265075 | Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of thrombin time at 100 uM after 3 mins (Rvb = 20.25 +/- 1.02 seconds) | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512084 | Induction of apoptosis in mouse CT26 cells assessed as appearance of condensed nuclei up to 40 uM after 48 hrs by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512119 | Induction of apoptosis in human HCT116 cells assessed as increase in Bax protein expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1515530 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production after 48 hrs by ELISA | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. |
| AID255967 | In vitro inhibitory concentration against human colorectal adenocarcinoma Caco-2 cells in the presence of vinblastine sulfate salt; NT: Not tested | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID1512101 | Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 10 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.87 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1265080 | Antioxidant activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 50 uM after 4 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
| AID1512077 | Inhibition of colony formation in mouse CT26 cells assessed as reduction in number of colonies up to 40 uM incubated for 24 hrs supplemented with fresh medium containing compound every 3 days for 12 days by crystal violet staining-based microscopic analys | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1756089 | Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system at 10 uM using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay relative to control | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. |
| AID1512072 | Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability up to 40 uM by MTT assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | | | |
| AID1512109 | Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 40 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.87 %) | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID388895 | Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512083 | Induction of apoptosis in human HCT116 cells assessed as appearance of condensed nuclei up to 40 uM after 48 hrs by Hoechst 33258 staining-based fluorescent microscopic analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512117 | Induction of apoptosis in human HCT116 cells assessed as decrease in Bcl-2 protein expression up to 40 uM after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID1512128 | Inhibition of STAT3 phosphorylation in human HCT116 cells after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID255916 | In vitro inhibitory concentration against renal adenocarcinoma cell line (ACHN) in the presence of taxol | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. |
| AID388896 | Partition coefficient, log P of the compound | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
| In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. |
| AID1512129 | Antimetastatic activity against mouse CT26 cells assessed as inhibition of MMP-9 expression after 48 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
| Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1799639 | Kinase Assay from Article 10.1002/cbic.201000487: \\Biological evaluation and structural determinants of p38u00CEu00B1 mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.\\ | 2010 | Chembiochem : a European journal of chemical biology, Dec-10, Volume: 11, Issue:18
| Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |