Compounds > garcinia biflavonoid 1
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garcinia biflavonoid 1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Garcinia biflavonoid 1: biflavone of Garcinia kola seeds; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
GarciniagenusA plant genus of the family CLUSIACEAE. Members contain XANTHONES.[MeSH]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]
Garcinia kolaspeciesA plant species of the family CLUSIACEAE. The common name of 'Bitter Kola' is sometimes also used to refer to COLA.[MeSH]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]

Cross-References

ID SourceID
PubMed CID161087
CHEMBL ID504319
MeSH IDM0155087

Synonyms (16)

Synonym
CHEMBL504319
(2r,3r)-8-[(2s,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
gb1 garcinia
garcinia biflavonoid 1
271565679c ,
unii-271565679c
(3,8'-bi-4h-1-benzopyran)-4,4'-dione, 2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2,2'-bis(4-hydroxyphenyl)-, (2s-(2alpha,3beta(2's*,3's*)))-
14736-58-4
DTXSID00163689
(3,8'-bi-4h-1-benzopyran)-4,4'-dione, 2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2,2'-bis(4-hydroxyphenyl)-, (2s-(2.alpha.,3.beta.(2's*,3's*)))-
3,8''-biflavanone, 3'',4',4''',5,5'',7,7''-heptahydroxy-
5,7,4',3'',5'',7'',4'''-heptahydroxy(3,8'')biflavanone
gb 1 (garcinia)
(2r,3r)-8-[(2s,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-chroman-3-yl]-3,5,7-trihydroxy-2-(4-hydroxyphenyl)chroman-4-one
Q27254150
(2s,2'r,3r,3'r)-3',5,5',7,7'-pentahydroxy-2,2'-bis(4-hydroxyphenyl)-[3,8'-bichroman]-4,4'-dione

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The ability of butylated hydroxyanisole (BHA) to attenuate the toxic effect of 2-AAF was also examined."( Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.
Agboola, AO; Emerole, GO; Farombi, EO; Nwankwo, JO; Tahnteng, JG, 2000)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID376711Cytotoxicity against human Raji cells assessed as cell viability at 3.2 nmol by trypan blue staining1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID376707Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 3.2 nmol after 48 hrs relative to TPA1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID1696172Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method2020Journal of natural products, 07-24, Volume: 83, Issue:7
Garcinoic Acids and a Benzophenone Derivative from the Seeds of
AID376705Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 32 nmol after 48 hrs relative to TPA1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID1696171Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method2020Journal of natural products, 07-24, Volume: 83, Issue:7
Garcinoic Acids and a Benzophenone Derivative from the Seeds of
AID1696174Bactericidal activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method2020Journal of natural products, 07-24, Volume: 83, Issue:7
Garcinoic Acids and a Benzophenone Derivative from the Seeds of
AID376706Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 16 nmol after 48 hrs relative to TPA1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID376709Cytotoxicity against human Raji cells assessed as cell viability at 32 nmol by trypan blue staining1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID1696173Antibacterial activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method2020Journal of natural products, 07-24, Volume: 83, Issue:7
Garcinoic Acids and a Benzophenone Derivative from the Seeds of
AID376710Cytotoxicity against human Raji cells assessed as cell viability at 16 nmol by trypan blue staining1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID376712Cytotoxicity against human Raji cells assessed as cell viability at 0.32 nmol by trypan blue staining1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
AID376708Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 0.32 nmol after 48 hrs relative to TPA1999Journal of natural products, Dec, Volume: 62, Issue:12
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's2 (28.57)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		2102-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.0810cadmium molecular entity;
zinc group element atom
kolaviron
kolaviron: antihepatotoxic fraction of biflavonones from Garcinia kola seeds; phalloidine antagonist. kolaflavanone : A biflavonoid isolated from the seeds of Garcinia kola that has been shown to exhibit hepatoprotective activity.		2.7304'-methoxyflavanones;
biflavonoid;
dihydroflavonols;
ring assembly;
secondary alpha-hydroxy ketone		hepatoprotective agent;
plant metabolite
garcinia biflavonoid 2
Garcinia biflavonoid 2: biflavone of Garcinia kola seeds		3.1150
amygdalin
[no description available]		3.1610
quercetin
[no description available]		2.08107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
chlorhexidine
Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.		2.2510biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
glutinol
glutinol: from a medicinal lichen, Usnea longissima; structure in first source. glutinol : A pentacyclic triterpenoid that is picene which has been fully hydrogenated except for a double bond between the 4a and 5 positions and is substituted by methyl groups at the 4, 4, 6bbeta, 8abeta, 11, 11, 12balpha and 14bbeta positions, and by a hydroxy group at the 3beta position.		2.2510pentacyclic triterpenoid;
secondary alcohol
trans-delta-tocotrienoloic acid
tocotrienoloic acid: from leaves of Tovomitopsis psychotriifolia; structure given in first source		2.2510tocotrienol
ConditionIndicatedRelationship StrengthStudiesTrials
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.		0210
Acute Liver Injury, Drug-Induced
[description not available]		02.3920
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		0210
Liver Dysfunction
[description not available]		02.3920
Liver Diseases
Pathological processes of the LIVER.		02.3920
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.3920
Carbon Tetrachloride Poisoning
Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.		01.9710