Target type: molecularfunction
Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + 2 ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + 2 ADP + 2 H+. [RHEA:32359]
Inositol-1,4,5-trisphosphate 6-kinase (IP6K) activity plays a crucial role in cellular signaling pathways by catalyzing the phosphorylation of inositol 1,4,5-trisphosphate (IP3) at the 6-position, generating inositol 1,4,5,6-tetrakisphosphate (IP4). This enzymatic reaction is essential for regulating intracellular calcium levels and various cellular processes, including:
1. **Calcium Signaling:** IP3, a key second messenger, binds to and opens IP3 receptors on the endoplasmic reticulum (ER) membrane, releasing calcium into the cytoplasm. IP6K, by producing IP4, contributes to the regulation of IP3 levels and thus the amplitude and duration of calcium signals.
2. **Transcriptional Regulation:** IP4 has been implicated in regulating gene expression by modulating the activity of transcription factors, such as nuclear factor of activated T cells (NFAT) and CREB.
3. **Cell Growth and Proliferation:** IP6K activity has been linked to cell growth and proliferation. It has been shown to promote cell cycle progression and regulate the expression of genes involved in cell growth.
4. **Apoptosis and Cell Death:** IP6K has been implicated in both pro-apoptotic and anti-apoptotic signaling pathways. Its precise role in these pathways may depend on the specific cellular context.
5. **Synaptic Plasticity:** IP6K activity is involved in synaptic plasticity, the ability of synapses to strengthen or weaken in response to activity. It has been shown to regulate the release of neurotransmitters and the formation of new synapses.
6. **Immune Response:** IP6K activity has been associated with the regulation of immune responses. It has been shown to modulate the activation and function of immune cells.
In summary, inositol-1,4,5-trisphosphate 6-kinase activity is a critical regulator of cellular signaling pathways. It plays a pivotal role in calcium homeostasis, transcriptional regulation, cell growth and proliferation, apoptosis, synaptic plasticity, and immune responses.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Inositol polyphosphate multikinase | An inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 3',4'-dihydroxyflavone | 3',4'-dihydroxyflavone: inhibitors of arachidonic acid peroxidation | ||
| 4',6-dihydroxyflavone | 4',6-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 4' and 6. | dihydroxyflavone | |
| naringenin | (S)-naringenin : The (S)-enantiomer of naringenin. | (2S)-flavan-4-one; naringenin | expectorant; plant metabolite |
| eriodictyol | eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively. eriodictyol: structure | 3'-hydroxyflavanones; tetrahydroxyflavanone | |
| quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
| acacetin | 5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin. | dihydroxyflavone; monomethoxyflavone | anticonvulsant; plant metabolite |
| apigenin | Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia. | trihydroxyflavone | antineoplastic agent; metabolite |
| luteolin | 3'-hydroxyflavonoid; tetrahydroxyflavone | angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist | |
| kaempferol | 7-hydroxyflavonol; flavonols; tetrahydroxyflavone | antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite | |
| diosmetin | 3'-hydroxyflavonoid; monomethoxyflavone; trihydroxyflavone | angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; bone density conservation agent; cardioprotective agent; plant metabolite; tropomyosin-related kinase B receptor agonist; vasodilator agent | |
| genkwanin | genkwanin : A monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated. genkwanin: structure | dihydroxyflavone; monomethoxyflavone | metabolite |
| 3-methylquercetin | isorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group. | 7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone | anticoagulant; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite |
| myricetin | 7-hydroxyflavonol; hexahydroxyflavone | antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite | |
| rhamnetin | rhamnetin : A monomethoxyflavone that is quercetin methylated at position 7. rhamnetin: aglycone of xanthorhamnin; from Rhamnus | monomethoxyflavone; tetrahydroxyflavone | anti-inflammatory agent; antioxidant; metabolite |
| 4',7-dihydroxyflavone | 4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7. 4',7-dihydroxyflavone: inducer of nod gene | dihydroxyflavone | metabolite |