| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1196628 | Fraction unbound in cynomolgus monkey plasma at 1 uM by equilibrium dialysis method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196635 | AUC (infinity) in fasted cynomolgus monkey at 0.3 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196644 | Plasma concentration in male Sprague-Dawley rat at 0.3 mg/ml, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196645 | Anxiolytic activity po dosed in male NMRI mouse assessed as reduction of stress-induced hyperthermia measured after 1 hr | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196630 | Clearance in cynomolgus monkey at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196612 | Half life in male Wistar rat at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196624 | Ratio of drug level in brain to plasma in male Wistar rat | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1456884 | Antidepressant-like activity in po dosed rat assessed as reduction in immobility time by forced swim test | | | |
| AID1196595 | Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196607 | Genotoxicity in mouse L5178Ytk+/- cells assessed as occurrence of micronucleation event measured with metabolic activation at 70 ug/ml after 24 hrs by fluorescence/light microscopy with phase contrast | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1614114 | Increase in threshold of bladder-filling volume in rat | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5. |
| AID1196654 | Teratogenic effect in mouse D3 cells assessed as cell differentiation after 3 days by light microscopy | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196620 | Cmax in male Wistar rat at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196641 | Metabolic stability in human liver microsomes assessed as covalent protein binding at 20 uM at pH 7.4 after 60 mins by LC-MS/MS analysis relative to control | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196647 | Anxiolytic activity po dosed in male Sprague-Dawley rat assessed as fear-potentiated startle response measured after 1 hr on third day before test session by fear-potentiated startle response assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196597 | Displacement of [3H]flumazenil from rat cortex GABAA receptor BDZ binding site expressed in HEK293 cells by competition binding assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196639 | AUC (infinity) in fed cynomolgus monkey at 0.3 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196646 | Anxiolytic activity po dosed in male Sprague-Dawley rat assessed as lever press within conditioning period measured after 1 hr by conditioned emotional response assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196636 | Oral bioavailability in fasted cynomolgus monkey at 0.3 mg/kg | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196634 | Tmax in fasted cynomolgus monkey at 03 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196625 | Ratio of drug level in CSF to plasma in male Wistar rat | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196626 | Fraction unbound in mouse plasma at 1 uM by equilibrium dialysis method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196611 | Volume of distribution at steady state in male Wistar rat at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196598 | Inhibition of human ERG channel | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196642 | Displacement of [3H]ABP688 from mGlu5 receptor in po dosed Sprague-Dawley rat assessed as receptor occupancy in plasma measured after 30 mins | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196629 | Fraction unbound in human plasma at 1 uM by equilibrium dialysis method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196610 | Clearance in male Wistar rat at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196631 | Volume of distribution at steady state cynomolgus monkey at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196632 | Half life in cynomolgus monkey at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196621 | Tmax in male Wistar rat at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196600 | Intrinsic clearance in human liver microsomes at 1 uM during 30 mins incubation | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196605 | Mutagenicity in Salmonella typhimurium TA102 after 2 days by Ames test in presence of rat liver S9 fraction | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196596 | Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incubated for 30 mins prior to L-AP4 induction by Fluo-4 AM staining-based fluorescence assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196622 | AUC (infinity) in male Wistar rat at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196623 | Oral bioavailability in male Wistar rat at 10 mg/kg | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196638 | Tmax in fed cynomolgus monkey at 03 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196606 | Genotoxicity in mouse L5178Ytk+/- cells assessed as occurrence of micronucleation event measured without metabolic activation at 28 ug/ml after 24 hrs by fluorescence/light microscopy with phase contrast | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196609 | Anxiolytic activity in po dosed male Sprague-Dawley rat assessed as increase in drinking time after 1 hr by Vogel conflict test | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196652 | Teratogenic effect in mouse D3 cells assessed as cell viability after 10 days with two changes in medium on day 3 and 5 by MTT assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196601 | Mutagenicity in Salmonella typhimurium TA1535 after 2 days by Ames test in presence of rat liver S9 fraction | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196603 | Mutagenicity in Salmonella typhimurium TA98 after 2 days by Ames test in presence of rat liver S9 fraction | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196608 | Metabolic stability in human liver microsomes assessed as level of GSH adduct at 20 uM at pH 7.4 after 60 mins by LC-MS/MS analysis relative to control | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196627 | Fraction unbound in rat plasma at 1 uM by equilibrium dialysis method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196643 | Plasma concentration in male Sprague-Dawley rat at 0.03 mg/ml, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196602 | Mutagenicity in Salmonella typhimurium TA97 after 2 days by Ames test in presence of rat liver S9 fraction | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196640 | Oral bioavailability in fed cynomolgus monkey at 0.3 mg/kg | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196604 | Mutagenicity in Salmonella typhimurium TA100 after 2 days by Ames test in presence of rat liver S9 fraction | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196599 | Intrinsic clearance in male rat liver microsomes at 1 uM during 30 mins incubation | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196637 | Cmax in fed cynomolgus monkey at 0.3 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1196633 | Cmax in fasted cynomolgus monkey at 0.3 mg/kg, po | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| AID1346269 | Human mGlu5 receptor (Metabotropic glutamate receptors) | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3
| Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |