Compounds > liridine
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liridine

Description

liridine: Antibacterial from Artabotrys crassifolius; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ArtabotrysgenusA plant genus of the family ANNONACEAE.[MeSH]AnnonaceaeThe custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

Cross-References

ID SourceID
PubMed CID145779
CHEMBL ID227533
MeSH IDM000613384

Synonyms (18)

Synonym
liridine
o-methylmoschatoline
homomoschatoline
o-methyl-moschatoline
CHEMBL227533
5140-38-5
7h-dibenzo(de,g)quinolin-7-one, 1,2,3-trimethoxy-
7h-dibenzo[de,g]quinolin-7-one, 1,2,3-trimethoxy-
noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2,3-trimethoxy-
o-methylisomoschatoline
1,2,3-trimethoxy-7h-dibenzo[de,g]quinolin-7-one
WXGQWNXTPSGPIX-UHFFFAOYSA-N
moschatoline, o-methyl-
DTXSID70199394
14,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13(17),14-octaen-8-one
nsc-785149
nsc785149
AKOS040746901

Bioassays (24)

Assay IDTitleYearJournalArticle
AID488644Antimicrobial activity against Candida dubliniensis ATCC 778157 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336369DNA damaging activity against rad 52 DNA repair gene deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488643Antimicrobial activity against Candida dubliniensis ATCC 777 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID380082Antileishmanial activity against Leishmania braziliensis MHOM/BR/95/IOCL-2033 promastigotes after 24 hrs2006Journal of natural products, Feb, Volume: 69, Issue:2
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
AID284362Inhibition of ConA-induced BALB/c mouse T cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488642Antimicrobial activity against Candida parapsilosis ATCC 22019 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID284361Cytotoxicity against BALB/c mouse spleen cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488634Antimicrobial activity against Staphylococcus aureus 7+ penicillinase positive + by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336372DNA damaging activity against wild type Saccharomyces cerevisiae expressing rad DNA repair gene assessed as drug level required to produce 12 mm zone of inhibition after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488637Antimicrobial activity against Escherichia coli ATCC 10538 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336370DNA damaging activity against rad 52 DNA repair gene/topoisomerase 1 deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition well after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488645Antioxidant activity assessed as trolox equivalents of peroxyl radical scavenging activity by ORAC assay2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488638Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID284363Inhibition of LPS-induced BALB/c mouse B cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488639Antimicrobial activity against Candida albicans ATCC 10231 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488635Antimicrobial activity against Staphylococcus aureus 8- penicillinase negative by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID1754175Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Tulipiferamide A, an Alkamide from
AID488641Antimicrobial activity against Candida glabrata ATCC 30070 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488636Antimicrobial activity against Staphylococcus epidermidis 6ep by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336371DNA damaging activity against rad 6 DNA repair gene deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition well after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488633Antimicrobial activity against Staphylococcus aureus ATCC 14458 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488640Antimicrobial activity against Candida tropicalis CT by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID380083Antileishmanial activity against Leishmania guyanensis MHOM/BR/95/IOCL-2092 promastigotes after 24 hrs2006Journal of natural products, Feb, Volume: 69, Issue:2
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
AID488632Antimicrobial activity against Kocuria rhizophila ATCC 9341 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
streptonigrin[no description available]medium10pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
liriodenine[no description available]medium50alkaloid antibiotic;
cyclic ketone;
organic heteropentacyclic compound;
oxacycle;
oxoaporphine alkaloid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
camptothecin[no description available]medium10delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
oxoglaucine[no description available]medium20isoquinoline alkaloid
lysicamine[no description available]medium40alkaloid antibiotic;
oxoaporphine alkaloid		metabolite
pentamidine[no description available]medium10aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
annomontine[no description available]medium20alkaloid;
aminopyrimidine;
beta-carbolines		antiparasitic agent;
metabolite
glaucine[no description available]medium10aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
isoteolin[no description available]medium10aporphine alkaloid
aristololactam a ii[no description available]medium10
corytuberine[no description available]medium10aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound		plant metabolite
aristololactam bii[no description available]medium10
norcepharadione b[no description available]medium10
piperolactam a[no description available]medium10alkaloid
cyclosporine[no description available]medium10homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
aristolactam aiiia[no description available]medium10
ketoconazole[no description available]medium10dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
chloramphenicol[no description available]medium10C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
quercetin 3-o-glucopyranoside[no description available]medium10beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
4-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
sakuranetin[no description available]medium10(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavonoid phytoalexin;
monomethoxyflavanone		antimycobacterial drug;
plant metabolite
atherospermidine[no description available]medium20oxoaporphine alkaloid
n-phenethylbenzamide[no description available]medium10
omega-n-methylarginine[no description available]medium10amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
4-allyl-2,6-dimethoxyphenol[no description available]medium10dimethoxybenzene;
phenols;
phenylpropanoid
lariciresinol[no description available]medium10aromatic ether;
lignan;
oxolanes;
phenols;
primary alcohol		antifungal agent;
plant metabolite
(2S,3R)-dihydrodehydrodiconiferyl alcohol[no description available]medium101-benzofurans;
guaiacols;
guaiacyl lignin;
primary alcohol
syringaresinol[no description available]medium10syringaresinolantineoplastic agent
feruloyltyramine[no description available]medium10tyraminesmetabolite
costunolide[no description available]medium10germacranolide;
heterobicyclic compound		anthelminthic drug;
antiinfective agent;
antineoplastic agent;
antiparasitic agent;
antiviral drug;
metabolite
eupatolide[no description available]medium10gamma-lactone;
germacranolide;
homoallylic alcohol;
secondary alcohol		antineoplastic agent;
plant metabolite
3-(4-hydroxy-3-methoxyphenyl)-n-(2-(4-hydroxy-3-methoxyphenyl)ethyl)-2-propenamide[no description available]medium10hydroxycinnamic acidmetabolite
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide[no description available]medium10aromatic amide;
thiophenes
isocorydine[no description available]medium10aporphine alkaloid
ConditionIndicatedRelationship StrengthStudiesTrials