Compounds > liridine
Page last updated: 2024-11-07

liridine

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Description

liridine: Antibacterial from Artabotrys crassifolius; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ArtabotrysgenusA plant genus of the family ANNONACEAE.[MeSH]AnnonaceaeThe custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

Cross-References

ID SourceID
PubMed CID145779
CHEMBL ID227533
MeSH IDM000613384

Synonyms (18)

Synonym
liridine
o-methylmoschatoline
homomoschatoline
o-methyl-moschatoline
CHEMBL227533
5140-38-5
7h-dibenzo(de,g)quinolin-7-one, 1,2,3-trimethoxy-
7h-dibenzo[de,g]quinolin-7-one, 1,2,3-trimethoxy-
noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2,3-trimethoxy-
o-methylisomoschatoline
1,2,3-trimethoxy-7h-dibenzo[de,g]quinolin-7-one
WXGQWNXTPSGPIX-UHFFFAOYSA-N
moschatoline, o-methyl-
DTXSID70199394
14,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13(17),14-octaen-8-one
nsc-785149
nsc785149
AKOS040746901
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID488644Antimicrobial activity against Candida dubliniensis ATCC 778157 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336369DNA damaging activity against rad 52 DNA repair gene deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488643Antimicrobial activity against Candida dubliniensis ATCC 777 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID380082Antileishmanial activity against Leishmania braziliensis MHOM/BR/95/IOCL-2033 promastigotes after 24 hrs2006Journal of natural products, Feb, Volume: 69, Issue:2
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
AID284362Inhibition of ConA-induced BALB/c mouse T cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488642Antimicrobial activity against Candida parapsilosis ATCC 22019 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID284361Cytotoxicity against BALB/c mouse spleen cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488634Antimicrobial activity against Staphylococcus aureus 7+ penicillinase positive + by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336372DNA damaging activity against wild type Saccharomyces cerevisiae expressing rad DNA repair gene assessed as drug level required to produce 12 mm zone of inhibition after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488637Antimicrobial activity against Escherichia coli ATCC 10538 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336370DNA damaging activity against rad 52 DNA repair gene/topoisomerase 1 deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition well after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488645Antioxidant activity assessed as trolox equivalents of peroxyl radical scavenging activity by ORAC assay2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488638Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID284363Inhibition of LPS-induced BALB/c mouse B cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID488639Antimicrobial activity against Candida albicans ATCC 10231 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488635Antimicrobial activity against Staphylococcus aureus 8- penicillinase negative by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID1754175Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Tulipiferamide A, an Alkamide from
AID488641Antimicrobial activity against Candida glabrata ATCC 30070 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488636Antimicrobial activity against Staphylococcus epidermidis 6ep by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID336371DNA damaging activity against rad 6 DNA repair gene deficient Saccharomyces cerevisiae mutant assessed as drug level required to produce 12 mm zone of inhibition well after 48 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
AID488633Antimicrobial activity against Staphylococcus aureus ATCC 14458 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID488640Antimicrobial activity against Candida tropicalis CT by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
AID380083Antileishmanial activity against Leishmania guyanensis MHOM/BR/95/IOCL-2092 promastigotes after 24 hrs2006Journal of natural products, Feb, Volume: 69, Issue:2
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
AID488632Antimicrobial activity against Kocuria rhizophila ATCC 9341 by broth dilution method2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.78 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.3110hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
vanillin
Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).		2.3110benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0510dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0310aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
streptonigrin
[no description available]		1.9810pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0510C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
isocorydine
isocorydine: from root tubers of Stephania Kwangsiensis H.S. Lo; RN given refers to (+-)-isomer; structure in Merck Index, 9th ed, #5017		2.1110aporphine alkaloid
liriodenine
liriodenine: structure given in first source. liriodenine : An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.		3.1450alkaloid antibiotic;
cyclic ketone;
organic heteropentacyclic compound;
oxacycle;
oxoaporphine alkaloid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
glaucine
glaucine: RN given refers to (+-)-isomer		2.0310aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		1.9810delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
sakuranetin
sakuranetin: major rice phytoalexin; RN given for ((S)-(-))-isomer; structure in first source. sakuranetin : A flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group.		2.3110(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavonoid phytoalexin;
monomethoxyflavanone		antimycobacterial drug;
plant metabolite
atherospermidine
atherospermidine: isoquinoline alkaloid from Artabotrys maingayi; structure given in first source		2.5820oxoaporphine alkaloid
n-phenethylbenzamide
N-phenethylbenzamide: has antioxidant activity; structure in first source		2.3110
oxoglaucine
1,2,9,10-tetramethoxy-7H-dibenzo(de,g)quinolin-7-one: a phosphatidylinositol 3-kinase p110alpha inhibitor that reactivates latent HIV-1; structure in first source		2.4420isoquinoline alkaloid
lysicamine
lysicamine: oxoaporphine alkaloid; structure in first source		2.9740alkaloid antibiotic;
oxoaporphine alkaloid		metabolite
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.3110amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
isoteolin
isoteolin: mixture of isomers isoboldine (RN 3019-51-0) & bracteoline (RN 25651-04-1)		2.0310aporphine alkaloid
aristololactam a ii
aristololactam A II: from the stems of Uvaria kweichowensis; structure in first source		2.0310
corytuberine
corytuberine: structure. (S)-corytuberine : An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer).		2.0310aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound		plant metabolite
aristololactam bii
aristololactam BII: isolated from Saururus cernuus; structure given in first source		2.0310
norcepharadione b
norcepharadione B: isolated from Houttynia cordata; structure in first source		2.0310
4-allyl-2,6-dimethoxyphenol
4-allyl-2,6-dimethoxyphenol: structure in first source. 4-allyl-2,6-dimethoxyphenol : A member of the class of phenols that is phenol substituted by an allyl group at position 4 and methoxy groups at positions 2 and 6 respectively.		2.3110dimethoxybenzene;
phenols;
phenylpropanoid
lariciresinol
lariciresinol: found in human urine. (+)-lariciresinol : A lignan that is tetrahydrofuran substituted at positions 2, 3 and 4 by 4-hydroxy-3-methoxyphenyl, hydroxymethyl and 4-hydroxy-3-methoxybenzyl groups respectively (the 2S,3R,4R-diastereomer).		2.3110aromatic ether;
lignan;
oxolanes;
phenols;
primary alcohol		antifungal agent;
plant metabolite
(2S,3R)-dihydrodehydrodiconiferyl alcohol
[no description available]		2.31101-benzofurans;
guaiacols;
guaiacyl lignin;
primary alcohol
syringaresinol
(+)-syringaresinol : The (7alpha,7'alpha,8alpha,8'alpha)-stereoisomer of syringaresinol.		2.3110syringaresinolantineoplastic agent
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		2.0510caffeic acidgeroprotector;
mouse metabolite
piperolactam a
piperolactam A: isolated from Houttynia cordata; structure in first source		2.0310alkaloid
annomontine
annomontine: antileishmanial pyrimidine-beta-carboline alkaloid from the bark extract of Annona foetida; structure in first source. annomontine : An alkaloid that is beta-carboline substituted at position C-1 by a 2-aminopyrimidin-4-yl moiety. An antiparasitic agent found in Annona montana and Annona foteida.		2.4520alkaloid;
aminopyrimidine;
beta-carbolines		antiparasitic agent;
metabolite
quercetin
[no description available]		2.05107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
feruloyltyramine
feruloyltyramine: structure given in first source; isolated from Cannabis sativa seeds, roots, leaves, and resin; induces hypothermia and motor incoordination in mice; moupinamide is (E)-isomer		2.3110tyraminesmetabolite
quercetin 3-o-glucopyranoside
quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells		2.0510beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
costunolide
[no description available]		2.3110germacranolide;
heterobicyclic compound		anthelminthic drug;
antiinfective agent;
antineoplastic agent;
antiparasitic agent;
antiviral drug;
metabolite
eupatolide
eupatolide: sesquiterpene lactone from Eupatorium formasanum HAY; structure. eupatolide : A germacranolide with formula C15H20O3, isolated from several Inula species. It exhibits anti-cancer properties.		2.3110gamma-lactone;
germacranolide;
homoallylic alcohol;
secondary alcohol		antineoplastic agent;
plant metabolite
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF		2.0310homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
3-(4-hydroxy-3-methoxyphenyl)-n-(2-(4-hydroxy-3-methoxyphenyl)ethyl)-2-propenamide
3-(4-hydroxy-3-methoxyphenyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)-2-propenamide: found in high concentration in Spinacia oleracea following administration of diphenyl ether herbicides; structure in first source; RN given refers to cpd without isomeric designation		2.3110hydroxycinnamic acidmetabolite
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide: an IKK-2 kinase inhibitor; structure in first source		2.3110aromatic amide;
thiophenes
aristolactam aiiia
Aristolactam AIIIa: polo-like kinase 1 (Plk1) inhibitor; structure in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials