Page last updated: 2024-12-08

n-acetyl-n'-beta-d-glucopyranosyl urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID446801
CHEMBL ID443455
SCHEMBL ID4307948
MeSH IDM0425368

Synonyms (11)

Synonym
n-acetyl-n'-beta-d-glucopyranosyl urea
DB03218 ,
1KTI
n-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]carbamoyl]acetamide
n-acetyl-n''-beta-d-glucopyranosyl urea
n-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-ylcarbamoyl)acetamide
bdbm50263770
1-acetyl-3-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yl)urea
CHEMBL443455 ,
SCHEMBL4307948
n-(acetylcarbamoyl)-beta-d-glucopyranosylamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Glycogen PhosphorylaseOryctolagus cuniculus (rabbit)Ki370.00004.6000126.4000370.0000AID977610
Chain A, Glycogen PhosphorylaseOryctolagus cuniculus (rabbit)Ki370.00004.6000126.4000370.0000AID977610
Chain A, Glycogen Phosphorylase, Muscle FormOryctolagus cuniculus (rabbit)Ki370.00004.6000126.4000370.0000AID977610
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)Ki321.25000.02504.89039.0000AID1186740; AID387864; AID427132; AID644850
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1186740Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
AID644850Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.82012Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
AID387864Inhibition of rabbit muscle glycogen phosphorylase b2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
AID427132Inhibition of rabbit muscle glycogen phosphorylase b2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
AID1811Experimentally measured binding affinity data derived from PDB2002European journal of biochemistry, Mar, Volume: 269, Issue:6
Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2002European journal of biochemistry, Mar, Volume: 269, Issue:6
Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]