n-acetyl-n'-beta-d-glucopyranosyl urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	446801
CHEMBL ID	443455
SCHEMBL ID	4307948
MeSH ID	M0425368

Synonyms (11)

Synonym
n-acetyl-n'-beta-d-glucopyranosyl urea
DB03218 ,
1KTI
n-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]carbamoyl]acetamide
n-acetyl-n''-beta-d-glucopyranosyl urea
n-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-ylcarbamoyl)acetamide
bdbm50263770
1-acetyl-3-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yl)urea
CHEMBL443455 ,
SCHEMBL4307948
n-(acetylcarbamoyl)-beta-d-glucopyranosylamine

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Glycogen Phosphorylase	Oryctolagus cuniculus (rabbit)	Ki	370.0000	4.6000	126.4000	370.0000	AID977610
Chain A, Glycogen Phosphorylase	Oryctolagus cuniculus (rabbit)	Ki	370.0000	4.6000	126.4000	370.0000	AID977610
Chain A, Glycogen Phosphorylase, Muscle Form	Oryctolagus cuniculus (rabbit)	Ki	370.0000	4.6000	126.4000	370.0000	AID977610
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	Ki	321.2500	0.0250	4.8903	9.0000	AID1186740; AID387864; AID427132; AID644850
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID1186740	Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
AID644850	Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.8	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
AID387864	Inhibition of rabbit muscle glycogen phosphorylase b	2008	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20	Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
AID427132	Inhibition of rabbit muscle glycogen phosphorylase b	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
AID1811	Experimentally measured binding affinity data derived from PDB	2002	European journal of biochemistry, Mar, Volume: 269, Issue:6	Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2002	European journal of biochemistry, Mar, Volume: 269, Issue:6	Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.63 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.42 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glucose alpha-D-glucose : D-Glucopyranose having alpha-configuration at the anomeric centre.. (1->6)-alpha-D-glucan : An alpha-D-glucan in which the glucose units are connected by (1->6) linkages.. (1->3)-alpha-D-glucan : An alpha-D-glucan in which the glucose units are connected by (1->3) linkages.	2.1	1	D-glucopyranose	mouse metabolite
5-thio-d-glucose 5-thio-D-glucose: RN given refers to 5-thio-D-glucose	2.1	1
n-benzoyl-n'-beta-d-glucopyranosyl urea [no description available]	3.14	5
2-(beta-D-glucosyl)benzimidazole [no description available]	2.05	1	benzimidazoles; C-glycosyl compound
2-(beta-D-glucosyl)benzothiazole [no description available]	2.05	1	benzothiazoles; C-glycosyl compound
gl-4 [no description available]	2.46	2
quercetin [no description available]	2.1	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
maltoheptaose maltoheptaose: consists of seven glucose residues in a linear 1,4-alpha-linkage; substrate for determining alpha-amylase in serum; RN given refers to (D-glucopyranose)-isomer. maltoheptaose : A maltoheptaose heptasaccharide in which the glucose residue at the reducing end is in the aldehydo open-chain form.. alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp : A maltoheptaose heptasaccharide consisting of six alpha-D-glucose residues and a D-glucose residue joined in sequence by (1->4) glycosidic bonds.	2.1	1	maltoheptaose heptasaccharide

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