Compounds > 3',4',7-trihydroxyflavone
Page last updated: 2024-08-01 16:25:10

3',4',7-trihydroxyflavone

Description

3',4',7-trihydroxyflavone: from the Sudanese medicinal plant Albizia zygia; structure in first source [MeSH]

7,3',4'-Trihydroxyflavone : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5322065
CHEMBL ID301624
SCHEMBL ID34405
CHEBI ID196247
MeSH IDM0593193

Synonyms (38)

Synonym
3'',4'',7-trihydroxyflavon
2-(3,4-dihydroxy-phenyl)-7-hydroxy-chromen-4-one
bdbm50077325
7,3'',4''-trihydroxyflavone
2-(3,4-dihydroxyphenyl)-7-hydroxy-4h-chromen-4-one
brn 0253031
7,3',4'-trihydroxyflavone
2-(3,4-dihydroxyphenyl)-7-hydroxy-4h-1-benzopyran-4-one
4h-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-hydroxy-
2150-11-0
3',4',7-trihydroxyflavone
CHEMBL301624 ,
3',4',7-trihydroxyflavon
LMPK12110042
2-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
CHEBI:196247
flavone, 7,3',4'-trihydroxy-
5-18-04-00590 (beilstein handbook reference)
15z ,
AKOS016009456
FT-0634068
4HLF
SCHEMBL34405
Q-100553
PVFGJHYLIHMCQD-UHFFFAOYSA-N
DTXSID30175836
mfcd00017434
2-(3,4-dihydroxyphenyl)-7-hydroxy-chromen-4-one
7, 3',4'-trihydroxyflavone
104666-14-0
Q23055239
flavone, 3',4',7-trihydroxy- (6ci,7ci,8ci); 2-(3,4-dihydroxyphenyl)-7-hydroxy-4h-1-benzopyran-4-one; 3',4',7-trihydroxyflavone; 3',4',7-trihydroxylflavone; 5-deoxyluteolin; 7,3',4'-trihydroxyflavone
t 414
D81760
BS-49064
3 inverted exclamation marka,4 inverted exclamation marka,7-trihydroxyflavone
HY-N2736
CS-0023236

Drug Classes (1)

ClassDescription
flavonesA member of the class of flavonoid with a 2-aryl-1-benzopyran-4-one (2-arylchromen-4-one) skeleton and its substituted derivatives.

Protein Targets (7)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Telomerase reverse transcriptaseHomo sapiens (human)IC5040.0000AID281989
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)IC500.6378AID735786
Poly [ADP-ribose] polymerase 1Homo sapiens (human)IC507.5429AID735783
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC502.0000AID1063904
Aldo-keto reductase family 1 member B1Bos taurus (cattle)IC506.5200AID34338
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)IC500.8705AID735784

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Km143.9300AID1063899; AID1063900
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Vmax0.0085AID1063899; AID1063900

Bioassays (33)

Assay IDTitleYearJournalArticle
AID1668637Inhibition of human liver FBP1 at 200 uM incubated for 5 mins by fluorescence method relative to control2020Journal of natural products, 05-22, Volume: 83, Issue:5
ISSN: 1520-6025		Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.
AID426715Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D102009Journal of natural products, Jul, Volume: 72, Issue:7
ISSN: 1520-6025		Antiplasmodial isoflavanones from the roots of Sophora mollis.
AID765677Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay2013European journal of medicinal chemistry, Sep, Volume: 67ISSN: 1768-3254Modulation of human neutrophils' oxidative burst by flavonoids.
AID596670Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 1 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
ISSN: 1464-3391		Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID1063900Activity at soybean LOX-1 using linoleic acid as substrate at 10 uM preincubated for 5 mins followed by substrate addition by Michaelis-Menten plot analysis2014European journal of medicinal chemistry, Jan-24, Volume: 72ISSN: 1768-3254Inhibition of LOX by flavonoids: a structure-activity relationship study.
AID180466Inhibitory effect on the oxidative degradation of membrane lipids (lipid peroxidation assay) in microsomes of rat.2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
ISSN: 0022-2623		Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity.
AID1063899Activity at soybean LOX-1 using linoleic acid as substrate at 25 uM preincubated for 5 mins followed by substrate addition by Michaelis-Menten plot analysis2014European journal of medicinal chemistry, Jan-24, Volume: 72ISSN: 1768-3254Inhibition of LOX by flavonoids: a structure-activity relationship study.
AID749999Binding affinity to recombinant paraoxonase-1 (unknown origin) expressed in Escherichia coli after 5 mins by Trp-fluorescence quenching method2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
ISSN: 1464-3391		The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study.
AID281989Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay2004Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
ISSN: 0022-2623		Catecholic flavonoids acting as telomerase inhibitors.
AID765681Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay2013European journal of medicinal chemistry, Sep, Volume: 67ISSN: 1768-3254Modulation of human neutrophils' oxidative burst by flavonoids.
AID735784Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assay2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
ISSN: 1520-4804		Screening and structural analysis of flavones inhibiting tankyrases.
AID34338Inhibition of ALR2 (aldose reductase) of bovine lens1999Journal of medicinal chemistry, Jun-03, Volume: 42, Issue:11
ISSN: 0022-2623		1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.
AID765679Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay2013European journal of medicinal chemistry, Sep, Volume: 67ISSN: 1768-3254Modulation of human neutrophils' oxidative burst by flavonoids.
AID596672Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 10 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
ISSN: 1464-3391		Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID735786Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
ISSN: 1520-4804		Screening and structural analysis of flavones inhibiting tankyrases.
AID426717Selectivity index, ratio of IC50 for CHO cells to IC50 for chloroquine-sensitive Plasmodium falciparum D102009Journal of natural products, Jul, Volume: 72, Issue:7
ISSN: 1520-6025		Antiplasmodial isoflavanones from the roots of Sophora mollis.
AID1063904Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 8 mins by enzyme immunoassay2014European journal of medicinal chemistry, Jan-24, Volume: 72ISSN: 1768-3254Inhibition of LOX by flavonoids: a structure-activity relationship study.
AID426716Cytotoxicity against CHO cells by MTT assay2009Journal of natural products, Jul, Volume: 72, Issue:7
ISSN: 1520-6025		Antiplasmodial isoflavanones from the roots of Sophora mollis.
AID201080Minimum inhibitory concentration, that inhibits growth of Staphylococcus aureus in the presence of subinhibitory (30 ug/mL) Berberine; Inactive2001Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
ISSN: 0022-2623		Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.
AID749998Binding affinity to recombinant paraoxonase-1 (unknown origin) expressed in Escherichia coli2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
ISSN: 1464-3391		The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study.
AID502292Antioxidant activity assessed as DDPH radical scavenging activity2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
ISSN: 1464-3405		Relationships between structures of hydroxyflavones and their antioxidative effects.
AID1063895Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk plot analysis2014European journal of medicinal chemistry, Jan-24, Volume: 72ISSN: 1768-3254Inhibition of LOX by flavonoids: a structure-activity relationship study.
AID765682Cytotoxicity against human neutrophils assessed as cell viability at 100 uM after 1 hr by trypan blue exclusion assay2013European journal of medicinal chemistry, Sep, Volume: 67ISSN: 1768-3254Modulation of human neutrophils' oxidative burst by flavonoids.
AID1063894Binding affinity to soybean LOX-1 at 1248 uM by STD-[1H] NMR spectroscopic analysis2014European journal of medicinal chemistry, Jan-24, Volume: 72ISSN: 1768-3254Inhibition of LOX by flavonoids: a structure-activity relationship study.
AID605243Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA2010Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
ISSN: 1520-4804		A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
AID232853Antioxidant activity was determined using trolox equivalent antioxidant capacity assay.2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
ISSN: 0022-2623		Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity.
AID596671Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 3 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
ISSN: 1464-3391		Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID765674Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay2013European journal of medicinal chemistry, Sep, Volume: 67ISSN: 1768-3254Modulation of human neutrophils' oxidative burst by flavonoids.
AID596673Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 30 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
ISSN: 1464-3391		Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID735783Inhibition of human recombinant ARTD1 by fluorescence assay2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
ISSN: 1520-4804		Screening and structural analysis of flavones inhibiting tankyrases.
AID1239713Anti-platelet activity in rat platelet rich plasma assessed as inhibition of ADP and calcium-induced platelet aggregation at 100 uM pre-incubated at 37 degC for 10 mins and measured 30 mins after ADP and calcium addition2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
ISSN: 1464-3405		Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men).
AID1334868Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method2017Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2
ISSN: 1464-3391		Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
ISSN: 1520-4804		Screening and structural analysis of flavones inhibiting tankyrases.

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.17)18.7374
1990's1 (4.17)18.2507
2000's4 (16.67)29.6817
2010's16 (66.67)24.3611
2020's2 (8.33)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
flavoxate
0
carboxylic ester;
flavones;
piperidines;
tertiary amino compound		antispasmodic drug;
muscarinic antagonist;
parasympatholytic		00low000000
flavone
0
flavonesmetabolite;
nematicide		00low000000
5-hydroxyflavone
0
flavones00low000000
flavodic acid
0
flavones00low000000
3-methylflavone-8-carboxylic acid
0
flavones;
oxo monocarboxylic acid		EC 3.1.4.* (phosphoric diester hydrolase) inhibitor00low000000
4'-amino-6-hydroxyflavone
0
flavones00low000000
2'-hydroxyflavone
0
flavones00low000000
2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one
0
flavones00low000000
2-[(4-oxo-2-phenyl-1-benzopyran-3-yl)oxy]acetic acid
0
flavones00low000000
cochliophilin a
0
flavones00low000000
2-[[5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-4-oxo-2-phenyl-1-benzopyran-7-yl]oxy]acetic acid tert-butyl ester
0
flavones;
tert-butyl ester		00low000000
Isolicoflavonol
0
flavones00low000000
Licoflavone A
0
flavones00low000000
5,7,2'-trihydroxyflavone
0
flavones00low000000
morusinol
0
flavones00low000000
Norartocarpetin
0
flavones00low000000
Licoflavone B
0
flavones00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
protocatechuic acid
1
catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite		201520159.0low000010
gallic acid
1
trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite		201520159.0low000010
dimethyl sulfoxide
1
sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger		2010201014.0low000100
naringenin
2
4'-hydroxyflavanones;
trihydroxyflavanone		2013201410.5low000020
catechin
1
hydroxyflavan2013201311.0low000010
7,8-dihydroxyflavone
3
dihydroxyflavoneantidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist		2001201019.0medium000300
aspirin
1
benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent		201520159.0low000010
chloroquine
1
aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug		2009200915.0low000100
masoprocol
1
catechols;
lignan;
tetrol		antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite		2014201410.0low000010
troglitazone
1
chromanes;
thiazolidinone		anticoagulant;
anticonvulsant;
antineoplastic agent;
antioxidant;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
hypoglycemic agent;
platelet aggregation inhibitor;
vasodilator agent		2011201113.0low000010
adenosine monophosphate
1
adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical		202020204.0low000010
methyl gallate
1
gallate esteranti-inflammatory agent;
antioxidant;
plant metabolite		201520159.0low000010
catechin
2
catechinantioxidant;
plant metabolite		2011201511.0low000020
emetine
1
isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor		2009200915.0low000100
flavanone
1
flavanones2011201113.0low000010
kainic acid
1
dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist		2010201014.0low000100
flavone
6
flavonesmetabolite;
nematicide		2010202010.5low000150
syringic acid
1
benzoic acids;
dimethoxybenzene;
phenols		plant metabolite201520159.0low000010
eriodictyol
2
flavanones2013201410.5high000020
3-hydroxyflavone
3
flavonols;
monohydroxyflavone		1999201117.3low001110
isovanillic acid
1
methoxybenzoic acid;
monohydroxybenzoic acid		antibacterial agent;
plant metabolite		201520159.0low000010
4-aminobenzhydrazide
1
2013201311.0low000010
butylated hydroxytoluene
1
phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector		1999199925.0low001000
silybin
1
aromatic ether;
benzodioxine;
flavonolignan;
polyphenol;
secondary alpha-hydroxy ketone		antineoplastic agent;
antioxidant;
hepatoprotective agent;
plant metabolite		2001200123.0low000100
baicalin
1
dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative		antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug		202020204.0low000010
5-hydroxyflavone
5
flavones1999202012.8medium001130
epicatechin
1
catechin;
polyphenol		antioxidant2011201113.0low000010
gallocatechol
1
catechin;
flavan-3,3',4',5,5',7-hexol		antioxidant;
food component;
plant metabolite		2011201113.0low000010
6-hydroxyflavone
1
hydroxyflavonoid2010201014.0low000100
hesperetin
1
3'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite		2013201311.0low000010
nobiletin
1
methoxyflavoneantineoplastic agent;
plant metabolite		2011201113.0low000010
4'-methoxyflavone
1
ether;
flavonoids		2001200123.0low000100
5,7,4'-trimethylapigenin
1
ether;
flavonoids		2011201113.0low000010
5,7-dimethoxyflavone
2
dimethoxyflavoneplant metabolite2001201118.0low000110
3,5,7,3',4'-pentamethoxyflavone
1
2011201113.0low000010
liquiritigenin
1
4',7-dihydroxyflavanonehormone agonist;
plant metabolite		201720177.0low000010
aromadedrin
1
4'-hydroxyflavanones;
dihydroflavonols;
secondary alpha-hydroxy ketone;
tetrahydroxyflavanone		metabolite201720177.0low000010
glabridin
1
hydroxyisoflavansantiplasmodial drug2013201311.0low000010
3',4'-dihydroxyflavone
7
2004202011.9high000250
3,3',4'-trihydroxyflavone
3
hydroxyflavan2000202014.0low001110
inermin
1
maackiain2009200915.0medium000100
2'-hydroxyflavone
1
flavones2010201014.0medium000100
4'-hydroxyflavone
5
2001202012.4high000230
sorbinil
1
azaspiro compound;
chromanes;
imidazolidinone;
organofluorine compound;
oxaspiro compound		antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor		1999199925.0low001000
naringenin
3
(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite		201320207.3low000030
taxifolin
3
taxifolinmetabolite201320208.3low000030
eriodictyol
4
3'-hydroxyflavanones;
tetrahydroxyflavanone		201120208.2low000040
farrerol
1
organic molecular entitymetabolite201520159.0low000010
5,6,7-trimethoxyflavone
1
trimethoxyflavoneanti-HSV-1 agent;
plant metabolite		202020204.0low000010
e-z cinnamic acid
1
cinnamic acidplant metabolite201520159.0low000010
3,2'-dihydroxyflavone
2
2010201014.0high000200
7-methoxyflavone
1
ether;
flavonoids		1999199925.0low001000
negletein
1
ether;
flavonoids		202020204.0low000010
5,7,3',4'-tetramethylluteolin
2
2001201118.0high000110
isoliquiritigenin
2
chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist		2009201114.0low000110
7,8,3'-trihydroxyflavone
3
2004201016.0high000300
3',4'-dimethoxyflavone
1
2001200123.0low000100
2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one
2
flavones2004201017.0high000200
7,8,4'-trihydroxyflavone
3
2001201019.0high000300
quercetin
10
7-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger		1999202012.7low001270
biochanin a
1
4'-methoxyisoflavones;
7-hydroxyisoflavones		antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor		2011201113.0low000010
acacetin
4
dihydroxyflavone;
monomethoxyflavone		anticonvulsant;
plant metabolite		201320208.0low000040
apigenin
7
trihydroxyflavoneantineoplastic agent;
metabolite		201120209.6low000070
luteolin
10
3'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist		1999202012.4low001180
quercitrin
1
alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite		201520159.0low000010
scopoletin
1
hydroxycoumarinplant growth regulator;
plant metabolite		2009200915.0low000100
herbacetin
1
7-hydroxyflavonol;
pentahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
plant metabolite		202020204.0low000010
gossypetin
4
7-hydroxyflavonol;
hexahydroxyflavone		plant metabolite2010202011.2low000220
chrysoeriol
4
monomethoxyflavone;
trihydroxyflavone		antineoplastic agent;
antioxidant;
metabolite		201320208.5low000040
quercetin 3-o-methyl ether
1
monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite		201520159.0low000010
ayanin
1
dihydroxyflavone;
trimethoxyflavone		plant metabolite2011201113.0low000010
quercetin 3-o-glucopyranoside
2
beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite		2011201511.0low000020
rutin
1
disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite		202020204.0low000010
kaempferol
6
7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite		201020209.7low000150
genistein
2
7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor		2011201312.0low000020
butein
1
chalcones;
polyphenol		antineoplastic agent;
antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
geroprotector;
hypoglycemic agent;
plant metabolite;
radiosensitizing agent;
tyrosine kinase inhibitor		2011201113.0low000010
okanin
1
benzenetriol;
chalcones		plant metabolite2004200420.0low000100
5,7-dihydroxychromone
1
chromones201520159.0low000010
apigenin dimethylether
1
dimethoxyflavone;
monohydroxyflavone		plant metabolite2011201113.0low000010
baicalein
3
trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger		2010202010.3low000120
chrysin
5
7-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite		2001202012.4low000230
datiscetin
1
7-hydroxyflavonol;
tetrahydroxyflavone		2010201014.0low000100
3,7,4'-trihydroxyflavone
1
hydroxyflavan202020204.0low000010
diosmetin
4
3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent		2001201712.8low000130
fisetin
3
3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite		2000201117.0low001110
galangin
2
7-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite		201020209.0low000110
gossypin
1
7-hydroxyflavonol;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone		neuroprotective agent;
plant metabolite		202020204.0low000010
hyperoside
1
beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		hepatoprotective agent;
plant metabolite		201520159.0low000010
3-methylquercetin
1
7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone		anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite		201520159.0low000010
morin
2
7-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent		201020209.0low000110
myricetin
4
7-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite		201020209.5low000130
norwogonin
3
trihydroxyflavoneantioxidant;
metabolite		2010202010.7medium000210
quercetagetin
1
flavonols;
hexahydroxyflavone		antioxidant;
antiviral agent;
plant metabolite		202020204.0low000010
rhamnetin
1
monomethoxyflavone;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
metabolite		2011201113.0low000010
robinetin
2
7-hydroxyflavonol;
pentahydroxyflavone		plant metabolite2010201710.5low000110
scutellarein
2
tetrahydroxyflavonemetabolite201020209.0low000110
tamarixetin
1
7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone		antioxidant;
metabolite		201720177.0low000010
tricetin
1
pentahydroxyflavoneantineoplastic agent;
metabolite		2010201014.0low000100
tricin
1
3'-methoxyflavones;
dimethoxyflavone;
trihydroxyflavone		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
metabolite		201720177.0low000010
wogonin
1
dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite		2011201113.0low000010
daidzein
2
7-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite		2011201312.0low000020
5'-methoxyhydnocarpin
1
2001200123.0medium000100
7-hydroxyflavone
6
hydroxyflavonoid1999202012.8low001140
tectochrysin
1
monohydroxyflavone;
monomethoxyflavone		antidiarrhoeal drug;
antineoplastic agent;
plant metabolite		2011201113.0low000010
4',7-dihydroxyflavone
6
dihydroxyflavonemetabolite1999202011.7medium001050
astragalin
1
beta-D-glucoside;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone		plant metabolite;
trypanocidal drug		2011201113.0low000010
ombuine
1
dimethoxyflavone;
flavonols;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite		2011201113.0low000010
5-hydroxy-3,3',4',7-tetramethoxyflavone
1
3'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone		plant metabolite2011201113.0low000010
6,7-dihydroxyflavone
2
1999201019.5low001100
7-hydroxy-3-(4-methoxyphenyl)-4-methylcoumarin
1
hydroxycoumarin;
monomethoxybenzene		2010201014.0medium000100
7-hydroxyisoflavone
1
7-hydroxyisoflavonesEC 1.14.14.14 (aromatase) inhibitor;
metabolite		2010201014.0low000100
3,7-dihydroxyflavone
1
hydroxyflavan2010201014.0low000100
4',7,8-trihydroxyisoflavone
1
isoflavones2009200915.0low000100
guajavarin
1
201520159.0low000010
3,7-dimethylgalangin
1
2011201113.0medium000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
gallic acid
1
trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite		201820186.0low000010
chloramphenicol
1
C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor		201820186.0low000010
benzofurans
1
201820186.0low000010
1,1-diphenyl-2-picrylhydrazyl
1
201720177.0low000010
butin
1
flavanones201820186.0low000010
apigenin
1
trihydroxyflavoneantineoplastic agent;
metabolite		201720177.0low000010
sulfuretin
1
1-benzofurans201820186.0low000010
baicalein
1
trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger		201720177.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Bone Loss, Osteoclastic0
2
201520178.0high000020

Bioavailability (1)

ArticleYear
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
Journal of medicinal chemistry, , Dec-09, Volume: 53, Issue:23		2010

Natural Sources (1)

ArticleYear
Screening and structural analysis of flavones inhibiting tankyrases.
Journal of medicinal chemistry, , May-09, Volume: 56, Issue:9		2013