Page last updated: 2024-08-05 15:50:29
LIM kinase inhibitor
An that interferes with the activity of any of the actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins.
ChEBI ID: 139074
Members (1)
| Member | Definition | Class |
|---|---|---|
| LimKi 3 | A member of the class of pyrazoles that is 1-(2,6-dichlorophenyl)-1H-pyrazole which is substituted by a difluoromethyl group at position 3 and by a 2-(isobutyrylamino)-1,3-thiazol-5-yl group at position 5. It is a a potent cell-permeable inhibitor of LIM kinase 1 and 2. | LimKi 3 |
Research
Studies (19)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 12 (63.16) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (100.00%) | 84.16% |
Protein Targets (13)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.0081 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 35.1973 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 13.2066 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 5.3547 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 5.3547 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| polyprotein | Zika virus | Potency | 13.2066 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 27.4038 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| LIM domain kinase 1 | Homo sapiens (human) | IC50 | 0.0577 | 8 | 8 |
| LIM domain kinase 2 | Homo sapiens (human) | IC50 | 0.0875 | 8 | 8 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| LIM domain kinase 1 | Homo sapiens (human) | Kd | 0.0590 | 1 | 1 |
| LIM domain kinase 2 | Homo sapiens (human) | Kd | 0.0570 | 1 | 1 |