Page last updated: 2024-08-05 15:50:29

LIM kinase inhibitor

An that interferes with the activity of any of the actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins.

ChEBI ID: 139074

Members (1)

MemberDefinitionClass
LimKi 3A member of the class of pyrazoles that is 1-(2,6-dichlorophenyl)-1H-pyrazole which is substituted by a difluoromethyl group at position 3 and by a 2-(isobutyrylamino)-1,3-thiazol-5-yl group at position 5. It is a a potent cell-permeable inhibitor of LIM kinase 1 and 2.LimKi 3

Research

Studies (19)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.26)29.6817
2010's6 (31.58)24.3611
2020's12 (63.16)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.354711
cytochrome P450 2D6Homo sapiens (human)Potency10.684011
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency6.008111
EWS/FLI fusion proteinHomo sapiens (human)Potency35.197344
Fumarate hydrataseHomo sapiens (human)Potency13.206611
GVesicular stomatitis virusPotency5.354711
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.354711
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.354712
Interferon betaHomo sapiens (human)Potency5.354711
polyproteinZika virusPotency13.206611
tyrosine-protein kinase YesHomo sapiens (human)Potency27.403811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
LIM domain kinase 1Homo sapiens (human)IC500.057788
LIM domain kinase 2Homo sapiens (human)IC500.087588

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
LIM domain kinase 1Homo sapiens (human)Kd0.059011
LIM domain kinase 2Homo sapiens (human)Kd0.057011