Compounds > Rhododendrin
Page last updated: 2024-12-08

Rhododendrin

Description

rhododendrin: isolated from leaves of Rhododendron plants; has anti-inflammatory properties [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID442538
CHEMBL ID1086682
CHEBI ID8832

Synonyms (23)

Synonym
497-78-9
rhododendrin
C09965 ,
(2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(2r)-4-(4-hydroxyphenyl)butan-2-yl]oxyoxane-3,4,5-triol
AC1L9D1B ,
chebi:8832 ,
(-)-rhododendrin
CHEMBL1086682 ,
betuloside
.beta.-d-glucopyranoside, 3-(4-hydroxyphenyl)-1-methylpropyl, (r)-
.beta.-d-glucopyranoside, (1r)-3-(4-hydroxyphenyl)-1-methylpropyl
(1r)-3-(4-hydroxyphenyl)-1-methylpropyl .beta.-d-glucopyranoside
5i7qr8c454 ,
beta-d-glucopyranoside, (1r)-3-(4-hydroxyphenyl)-1-methylpropyl
unii-5i7qr8c454
rhododendrin, (-)-
beta-d-glucopyranoside, 3-(4-hydroxyphenyl)-1-methylpropyl, (r)-
rhododendrin [mi]
(1r)-3-(4-hydroxyphenyl)-1-methylpropyl beta-d-glucopyranoside
(2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(1r)-3-(4-hydroxyphenyl)-1-methyl-propoxy]tetrahydropyran-3,4,5-triol
Q7321115
DTXSID80964353
(2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-(((r)-4-(4-hydroxyphenyl)butan-2-yl)oxy)tetrahydro-2h-pyran-3,4,5-triol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
glycosideA glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID182348Compound was tested for hepatoprotective activity against D-GalN-induced cytotoxicity in primary cultured rat hepatocytes at 10 uM dose1998Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica.
AID480668Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 100 uM after 20 mins by microplate reader assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells.
AID182350Compound was tested for hepatoprotective activity against D-GalN-induced cytotoxicity in primary cultured rat hepatocytes at 3 uM dose1998Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica.
AID480667Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 10 uM after 20 mins by microplate reader assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells.
AID182351Compound was tested for hepatoprotective activity against D-GalN-induced cytotoxicity in primary cultured rat hepatocytes at 30 uM dose1998Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica.
AID182349Compound was tested for hepatoprotective activity against D-GalN-induced cytotoxicity in primary cultured rat hepatocytes at 100 uM dose1998Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 66.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index66.31 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index206.95 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (66.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxidopamine
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.. oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).		2.2110benzenetriol;
catecholamine;
primary amino compound		drug metabolite;
human metabolite;
neurotoxin
topanol 354
Topanol 354: structure		1.9910methoxybenzenes;
phenols
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		1.9910alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
butylated hydroxytoluene
2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.		1.9910phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
imiquimod
Imiquimod: A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS.. imiquimod : An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.		2.1510imidazoquinolineantineoplastic agent;
interferon inducer
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		1.9910taxifolinmetabolite
glycosides
[no description available]		2.8930
rhododendrol
rhododendrol: structure in first source		2.0510
quercetin
[no description available]		2.05107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
platyphylloside
platyphylloside: from the bark of black alder, inhibits the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells; structure in first source		2.0510
(E)-1,7-Bis(4-hydroxyphenyl)hept-4-en-3-one
[no description available]		2.4220diarylheptanoid
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1510
Palmoplantaris Pustulosis
[description not available]		02.1510
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		07.1510
Idiopathic Parkinson Disease
[description not available]		02.2110
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)		02.2110
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