homosalate
Description
Homosalate is an organic compound that acts as a sunscreen. It is a salicylate derivative, meaning that it contains a salicylic acid group. Homosalate is a white, crystalline solid that is practically insoluble in water but soluble in alcohols and oils. It is used in various sunscreen products to protect the skin from the harmful effects of ultraviolet (UV) radiation. Homosalate absorbs UV rays in the UVB range, which are responsible for sunburns. It is generally well-tolerated by most people and has a low risk of causing skin irritation. It is often used in combination with other sunscreen ingredients, such as oxybenzone and avobenzone, to provide broad-spectrum protection against both UVA and UVB rays. Homosalate is commonly found in sunscreens, lotions, lip balms, and other cosmetic products. It is a popular choice for sunscreen formulations due to its effectiveness, relatively low cost, and good stability. Studies continue to be conducted on homosalate and other sunscreen ingredients to evaluate their long-term safety and efficacy.'
homosalate: cpd not photoallergenic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 8362 |
| CHEMBL ID | 1377575 |
| CHEBI ID | 91642 |
| SCHEMBL ID | 16207 |
| MeSH ID | M0167938 |
Synonyms (123)
| Synonym |
|---|
| PRESTWICK2_001090 |
| BRD-A34751532-001-03-6 |
| eusolex |
| 3,3,5-trimethylcyclohexyl salicylate |
| benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester |
| BSPBIO_001140 |
| homosalate (usp/inn) |
| D04450 |
| BPBIO1_001254 |
| 52253-93-7 |
| NCGC00091888-01 |
| AB00514041 |
| salicylic acid, 3,3,5-trimethylcyclohexyl ester |
| ccris 4885 |
| salicylic acid, m-homomenthyl ester |
| epa pesticide chemical code 076603 |
| nsc 164918 |
| homosalatum [inn-latin] |
| caswell no. 482b |
| 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate |
| homosalato [inn-spanish] |
| metahomomenthyl salicylate |
| einecs 204-260-8 |
| filtersol ''a'' |
| salicylic acid,3,5-trimethylcyclohexyl ester |
| nsc-164918 |
| heliophan |
| homosalate |
| nsc164918 |
| coppertone |
| 118-56-9 |
| m-homomenthyl salicylate |
| benzoic acid, 3,3,5-trimethylcyclohexyl ester |
| 3,5-trimethylcyclohexyl salicylate |
| component of coppertone |
| heliopan |
| homomenthyl salicylate |
| NCGC00091888-02 |
| SPBIO_003030 |
| PRESTWICK1_001090 |
| SPECTRUM1505020 |
| PRESTWICK3_001090 |
| NCGC00091888-03 |
| HMS2093G22 |
| T2278 |
| salicylic acid 3,3,5-trimethylcyclohexyl ester |
| 2-hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester |
| (3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate |
| HMS1571I22 |
| NCGC00091888-06 |
| NCGC00091888-04 |
| NCGC00091888-05 |
| HMS2098I22 |
| homosalate [usan:usp:inn] |
| homosalato |
| ec 204-260-8 |
| homosalatum |
| unii-v06sv4m95s |
| v06sv4m95s , |
| tox21_303082 |
| NCGC00257063-01 |
| dtxsid1026241 , |
| dtxcid606241 |
| NCGC00259658-01 |
| tox21_202109 |
| nsc758908 |
| nsc-758908 |
| pharmakon1600-01505020 |
| tox21_111174 |
| CHEMBL1377575 |
| S4572 |
| FT-0614020 |
| AKOS015904082 |
| homosalate [inci] |
| homosalate [usan] |
| homosalate [usp monograph] |
| homosalate [inn] |
| homosalate [mart.] |
| homosalate [who-dd] |
| homosalate [usp impurity] |
| homosalate [usp-rs] |
| homosalate [mi] |
| CCG-213330 |
| SCHEMBL16207 |
| NCGC00091888-09 |
| tox21_111174_1 |
| mfcd00019377 |
| component of coppertone (salt/mix) |
| kemester hms |
| filtrosol a |
| homosalat |
| HY-B0928 |
| AB00514041_02 |
| J-519754 |
| SR-05000001884-2 |
| sr-05000001884 |
| CHEBI:91642 |
| 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester |
| homosalate, united states pharmacopeia (usp) reference standard |
| SR-05000001884-1 |
| homosalate, pharmaceutical secondary standard; certified reference material |
| homosalate; salicylic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-trimethylcyclohexyl salicylate |
| SBI-0206787.P001 |
| HMS3715I22 |
| DB11064 |
| Q2260189 |
| AS-10409 |
| BRD-A34751532-001-04-4 |
| salicylic acid, 3,3,5-trimethylcyclohexyl ester (8ci) |
| E78223 |
| 2,3,3,4,4,5,5,6-octachlorobiphenyl |
| SY051923 |
| A921433 |
| EN300-7381967 |
| homosalato (inn-spanish) |
| homosalate (usp-rs) |
| homosalate (usan:usp:inn) |
| homosalate (mart.) |
| homosalate (usp impurity) |
| sun protection facial spf 50 |
| homosalate (usp monograph) |
| filtersol''a'' |
| homosalatum (inn-latin) |
Research Excerpts
Overview
Homosalate (HMS) is a salicylate UV filter broadly used in sunscreens and personal care products. It provides protection from the adverse effects of ultraviolet (UV) radiation exposure.
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " The systemic exposure dosage and margin of safety (MoS) for the identified UVFs were estimated using in-use concentrations and application patterns." | ( Dispersive liquid-liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens. Lukić, J; Onjia, A; Đurkić, T, 2023) | 1.12 |
Occurs in Manufacturing (7 Product(s))
Product Categories
Products
| Product | Brand | Category | Compounds Matched from Ingredients | Date Retrieved |
|---|---|---|---|---|
| Alba Botanica Hawaiian SPF 50 Sunscreen Lotion Island Vibe -- 3 oz | Alba | Beauty & Personal Care | orange, amyl cinnamal, citric acid, benzyl alcohol, cetearyl alcohol, cetyl alcohol, citral, citric acid, citronellol, triethyl citrate, geraniol, glycerin, dimethicone, homosalate, hydroxycitronellal, limonene, sodium benzoate | 2024-11-29 10:47:42 |
| Australian Gold Botanical Sunscreen Natural Spray Non-Sticky SPF 70 -- 6 fl oz | Australian Gold | Beauty & Personal Care | Avobenzone, Homosalate | 2024-11-29 10:47:42 |