Page last updated: 2024-12-08

asebogenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

asebogenin: from Piper longicaudatum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

asebogenin : A member of the class of dihydrochalcones that is the 4'-methyl ether derivative of phloretin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
PipergenusA plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.[MeSH]PiperaceaeA family of flowering plants in the order Piperales best known for the black pepper widely used in SPICES, and for KAVA and Betel used for neuroactive properties.[MeSH]

Cross-References

ID SourceID
PubMed CID442255
CHEMBL ID253257
CHEBI ID2871
SCHEMBL ID4740064
MeSH IDM0385475

Synonyms (15)

Synonym
C09471
phloretin 4'-methyl ether
520-42-3
asebogenin
LMPK12120545
CHEMBL253257
chebi:2871 ,
1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
SCHEMBL4740064
2',6',4-trihydroxy-4'-methoxy-dihydrochalcone
DTXSID60331781
Q27105855
dihydroisosakuranetin
XD161717
AKOS040761380

Research Excerpts

Overview

Asebogenin is a dihydrochalcone whose pharmacological effects remain largely unknown.

ExcerptReferenceRelevance
"Asebogenin is a dihydrochalcone whose pharmacological effects remain largely unknown."( Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation.
Chen, S; Fang, C; Huang, L; Li, H; Li, L; Liu, Y; Lv, K; Qiao, J; Tang, Z; Wang, H; Wang, J; Wang, X; Xu, X; Yao, G; Zhang, L; Zhang, Y; Zheng, G, 2023
)
3.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dihydrochalconesAny ketone that is 1,3-diphenylpropanone and its derivatives obtained by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID378512Inhibition of concanavalin A-induced mouse T cells proliferation assessed as [3H]TdR incorporation at 1 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID357253Inhibition of Saccharomyces cerevisiae fatty acid synthase2002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID332920Cytotoxicity against human KB cells after 72 hrs1994Journal of natural products, Jan, Volume: 57, Issue:1
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
AID381256Cytotoxicity against human 9KB cells assessed as cell survival at 100 ug/ml relative to control
AID378514Inhibition of LPS-induced mouse B cells proliferation assessed as [3H]TdR incorporation at 0.1 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID332922Antibacterial activity against Micrococcus luteus ATCC 9341 by bioautographic assay1994Journal of natural products, Jan, Volume: 57, Issue:1
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
AID332923Antibacterial activity against Escherichia coli ATCC 25922 by bioautographic assay1994Journal of natural products, Jan, Volume: 57, Issue:1
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
AID378511Inhibition of concanavalin A-induced mouse T cells proliferation assessed as [3H]TdR incorporation at 0.1 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID357255Antifungal activity against Cryptococcus neoformans ATCC 901132002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID378515Inhibition of LPS-induced mouse B cells proliferation assessed as [3H]TdR incorporation at 1 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID310811Antibacterial activity against methicillin-resistant Staphylococcus aureus2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID357254Antifungal activity against Candida albicans ATCC 900282002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID332924Molluscicidal activity against Biomphalaria glabrata assessed as mortality after 24 hrs by microscopy1994Journal of natural products, Jan, Volume: 57, Issue:1
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
AID378513Inhibition of concanavalin A-induced mouse T cells proliferation assessed as [3H]TdR incorporation at 10 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID332921Antibacterial activity against Bacillus subtilis ATCC 6633 by bioautographic assay1994Journal of natural products, Jan, Volume: 57, Issue:1
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
AID378516Inhibition of LPS-induced mouse B cells proliferation assessed as [3H]TdR incorporation at 10 uM by MTT assay2005Journal of natural products, Mar, Volume: 68, Issue:3
Dihydrochalcones from the leaves of Pieris japonica.
AID310794Antibacterial activity against Staphylococcus aureus2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID381257Cytotoxicity against human 9KB cells assessed as cell survival at 10 ug/ml relative to control
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's4 (44.44)29.6817
2010's2 (22.22)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.65 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.05 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]