Page last updated: 2024-10-24

multicellular organismal-level water homeostasis

Definition

Target type: biologicalprocess

A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [GOC:dph, GOC:tb]

Multicellular organisms maintain water homeostasis through a complex interplay of physiological processes that regulate water intake, water loss, and water distribution throughout the body. This intricate balance is crucial for cell function, nutrient transport, waste removal, and overall organismal survival.

**Water Intake:**

* **Drinking:** Animals obtain water directly from their environment by drinking.
* **Food:** Water is also consumed through food intake.
* **Metabolic Water:** Some organisms generate water as a byproduct of metabolism, particularly in situations of limited external water availability.

**Water Loss:**

* **Evaporation:** Water is lost through evaporation from respiratory surfaces, skin, and other body surfaces.
* **Excretion:** Water is excreted in urine and feces.
* **Sweating:** In mammals, sweating helps regulate body temperature through evaporative cooling, but also leads to water loss.

**Water Regulation:**

* **Osmosis:** The movement of water across cell membranes is driven by osmotic gradients, ensuring cells maintain appropriate water content.
* **Hormonal Regulation:** Hormones like antidiuretic hormone (ADH) and aldosterone play critical roles in regulating water reabsorption in the kidneys, influencing urine volume and water conservation.
* **Kidney Function:** The kidneys filter blood and reabsorb water, adjusting urine output to maintain water balance.
* **Behavioral Adaptations:** Some animals exhibit behavioral adaptations for water conservation, such as seeking shade during the day or reducing activity during periods of water scarcity.

**Maintaining Water Balance:**

* **Hypoosmotic Regulation:** Organisms in freshwater environments actively excrete excess water and conserve solutes to maintain their internal osmotic balance.
* **Hyperosmotic Regulation:** Marine animals constantly face the threat of water loss due to the high salinity of their environment. They have evolved mechanisms to conserve water and excrete excess salts.
* **Dehydration:** Water loss exceeding intake can lead to dehydration, which can disrupt physiological functions and even be fatal.

**Factors Affecting Water Homeostasis:**

* **Environmental Factors:** Temperature, humidity, and water availability in the environment significantly impact water balance.
* **Physiological Factors:** Age, health status, and metabolic rate can influence water requirements.
* **Lifestyle Factors:** Exercise and activity levels impact water loss through sweat.

**Disruption of Water Homeostasis:**

* **Dehydration:** Imbalances in water intake and loss can lead to dehydration, which can affect cellular function and organ systems.
* **Edema:** Fluid accumulation in tissues due to disruptions in water balance can cause swelling.
* **Kidney Disease:** Impaired kidney function can disrupt water regulation, leading to electrolyte imbalances and other complications.

In summary, multicellular organisms have evolved intricate mechanisms to maintain water homeostasis. These processes involve water intake, water loss, and regulation, all working in concert to ensure optimal cellular function and overall organismal survival.'
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Proteins (4)

ProteinDefinitionTaxonomy
Transient receptor potential cation channel subfamily V member 4A transient receptor potential cation channel TRPV4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HBA0]Homo sapiens (human)
Amiloride-sensitive sodium channel subunit alphaAn amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37088]Homo sapiens (human)
Aquaporin-1An aquaporin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29972]Homo sapiens (human)
Cystic fibrosis transmembrane conductance regulatorA cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human. [PRO:CNA, UniProtKB:P13569]Homo sapiens (human)

Compounds (26)

CompoundDefinitionClassesRoles
cannabinolCannabinol: A physiologically inactive constituent of Cannabis sativa L.dibenzopyran
glyburideglyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
monochlorobenzenes;
N-sulfonylurea
anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
methyl anthranilatemethyl anthranilate : A benzoate ester that is the methyl ester of anthranilic acid.benzoate esterflavouring agent;
metabolite
amilorideamiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.

Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
aromatic amine;
guanidines;
organochlorine compound;
pyrazines
diuretic;
sodium channel blocker
cannabichromene1-benzopyran
telmisartantelmisartan : A member of the class of benzimidazoles used widely in the treatment of hypertension.

Telmisartan: A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.
benzimidazoles;
biphenyls;
carboxybiphenyl
angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic
(6ar-trans)-isomer of tetrahydrocannabivarin 9
benzamilguanidines;
pyrazines
tadalafilbenzodioxoles;
pyrazinopyridoindole
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
vasodilator agent
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine
hc 0300312-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: a TRPA1 channel blocker
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone: a cystic fibrosis transmembrane conductance regulator inhibitor; structure in first source
hc-067047HC-067047: a TRPA1 antagonist; structure in first source
uccf-029organic heterotricyclic compound;
organooxygen compound
rn 1734RN 1734: a TRPV4 antagonist; structure in first source
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigeninChamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.trihydroxyflavoneantineoplastic agent;
metabolite
rutinHydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone
antioxidant;
metabolite
genistein7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
cgp 71683 anaphthalenes;
sulfonic acid derivative
cannabigerolcannabigerol : A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.

cannabigerol: RN given refers to (E)-isomer; structure given in first source
phytocannabinoid;
resorcinols
anti-inflammatory agent;
antibacterial agent;
antioxidant;
appetite enhancer;
cannabinoid receptor agonist;
neuroprotective agent;
plant metabolite
cannabidivarincannabidivarin: from Cannabis sativamonoterpenoid
vx-770ivacaftor : An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.

ivacaftor: a CFTR potentiator; structure in first source
aromatic amide;
monocarboxylic acid amide;
phenols;
quinolone
CFTR potentiator;
orphan drug
lumacaftorlumacaftor : An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.

lumacaftor: a corrector of CF transmembrane conductance regulator (CTFR); structure in first source
aromatic amide;
benzodioxoles;
benzoic acids;
cyclopropanes;
organofluorine compound;
pyridines
CFTR potentiator;
orphan drug
gsk 1016790aGSK1016790A : A tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.1-benzothiophenes;
aromatic primary alcohol;
dichlorobenzene;
N-acylpiperazine;
sulfonamide;
tertiary carboxamide
TRPV4 agonist
phenylamilphenylamil: irreversible inhibitor of sodium channels in the toad urinary bladderguanidines;
pyrazines