| Assay ID | Title | Year | Journal | Article |
|---|
| AID303336 | Inhibition of Escherichia coli beta-lactamase | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. |
| AID228517 | Aggregates forming ability by dynamic light scattering(DLS). | 2002 | Journal of medicinal chemistry, Apr-11, Volume: 45, Issue:8
| A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
| AID1154638 | Competitive inhibition of Escherichia coli beta-lactamase AmpC using nitrocefin as substrate by UV-Vis spectrophotometry | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
| Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. |
| AID43258 | Percentage inhibition against beta-Lactamase in the presence of detergent 0.01% Triton X-100 was determined at a concentration of 0.6 uM | 2003 | Journal of medicinal chemistry, Sep-25, Volume: 46, Issue:20
| A specific mechanism of nonspecific inhibition. |
| AID38397 | Binding affinity towards AmpC beta-lactamase binding site from Escherichia coli | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| Structure-based approach for binding site identification on AmpC beta-lactamase. |
| AID218681 | Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of buffer | 2002 | Journal of medicinal chemistry, Apr-11, Volume: 45, Issue:8
| A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
| AID38396 | Compound was tested for its specificity against AmpC beta-lactamase | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID43248 | Percentage inhibition against beta-Lactamase in the absence of detergent Triton X-100 was determined at a concentration of 0.6 uM | 2003 | Journal of medicinal chemistry, Sep-25, Volume: 46, Issue:20
| A specific mechanism of nonspecific inhibition. |
| AID218690 | Decrease in inhibition of beta-lactamase due to 10-fold increase in enzyme concentration; No change | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Kinase inhibitors: not just for kinases anymore. |
| AID67675 | Compound was tested for its specificity against Elastase | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID303338 | Antibacterial activity against Escherichia coli K12 JM109 overexpressing beta-lactamase | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. |
| AID43124 | Inhibitory activity against Amp C beta-Lactamase | 2003 | Journal of medicinal chemistry, Sep-25, Volume: 46, Issue:20
| A specific mechanism of nonspecific inhibition. |
| AID346656 | Inhibition of human recombinant MGL | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
| Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. |
| AID218682 | Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of buffer | 2002 | Journal of medicinal chemistry, Apr-11, Volume: 45, Issue:8
| A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
| AID218680 | Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of buffer | 2002 | Journal of medicinal chemistry, Apr-11, Volume: 45, Issue:8
| A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
| AID346655 | Inhibition of Wistar rat brain FAAH assessed as [3H]arachidonoylethanolamide hydrolysis | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
| Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. |
| AID36989 | Compound was tested for its specificity against alpha-chymotrypsin | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID437825 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X assessed as residual activity at 1000 uM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitroben | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1154639 | Competitive inhibition of wild type beta-lactamase TEM-1 (unknown origin) expressed in Escherichia coli using 6-beta-furylacryloylamido-penicillanic acid as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
| Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. |
| AID44381 | Compound was tested for its specificity against beta-trypsin | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID437828 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X assessed as residual activity at 1000 uM preincubated for 4 hrs before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitroben | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID437817 | Inhibition of Actinomadura sp. R39 penicillin-binding protein assessed as residual activity at 1000 uM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenzoic ac | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID218691 | Increase in inhibition of beta-lactamase due to the effect of incubation; No change | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Kinase inhibitors: not just for kinases anymore. |
| AID1154640 | Competitive inhibition of wild type beta-lactamase CTX-M-9 (unknown origin) expressed in Escherichia coli BL21(DE3) using 6-beta-furylacryloylamido-penicillanic acid as substrate by UV-Vis spectrophotometry | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
| Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. |
| AID218679 | Inhibition of beta-lactamase from Escherichia coli | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Kinase inhibitors: not just for kinases anymore. |
| AID303337 | Dissociation constant, pKa of the compound | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. |
| AID38398 | Inhibitory activity against Escherichia coli AmpC beta-lactamase. | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID218575 | Inhibitory activity against beta-lactamase | 2002 | Journal of medicinal chemistry, Apr-11, Volume: 45, Issue:8
| A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
| AID1799826 | Enzymatic Protein Activity Assay from Article 10.1002/cbic.201200571: \\Boron-based inhibitors of acyl protein thioesterases 1 and 2.\\ | 2013 | Chembiochem : a European journal of chemical biology, Jan-02, Volume: 14, Issue:1
| Boron-based inhibitors of acyl protein thioesterases 1 and 2. |
| AID1798637 | FAAH Inhibition Assay from Article 10.1021/jm801051t: \\Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase.\\ | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
| Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2010 | Journal of molecular biology, Feb-12, Volume: 396, Issue:1
| Structural bases for stability-function tradeoffs in antibiotic resistance. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23
| Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |