Page last updated: 2024-08-05 15:50:47

PAR2 negative allosteric modulator

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ChEBI ID: 189675

Members (1)

MemberDefinitionClass
AZ3451A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties.AZ3451

Research

Studies (7)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Proteinase-activated receptor 1Homo sapiens (human)IC5050.000011
Proteinase-activated receptor 2Homo sapiens (human)IC503.301222
Proteinase-activated receptor 4Homo sapiens (human)IC500.380011