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ChEBI ID: 189675
Member | Definition | Class |
---|---|---|
AZ3451 | A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties. | AZ3451 |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 2 (28.57) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Proteinase-activated receptor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
Proteinase-activated receptor 2 | Homo sapiens (human) | IC50 | 3.3012 | 2 | 2 |
Proteinase-activated receptor 4 | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |