cellular response to flavonoid

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22700048]

Cellular response to flavonoids is a complex process that involves multiple signaling pathways and cellular events. Flavonoids, a diverse group of plant-derived polyphenols, exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The molecular mechanisms underlying these effects involve interactions with various cellular targets, including enzymes, receptors, and transcription factors.

Upon entering the cell, flavonoids can interact with specific receptors, such as estrogen receptors, nuclear factor kappa B (NF-κB), and peroxisome proliferator-activated receptors (PPARs). These interactions can modulate gene expression, leading to changes in cellular function. For example, flavonoids can activate PPARs, promoting lipid metabolism and reducing inflammation. They can also inhibit NF-κB, a key regulator of inflammation, by blocking its translocation to the nucleus.

Flavonoids can also act as antioxidants by scavenging free radicals and preventing oxidative stress. This protective effect is particularly important in preventing damage to DNA and other cellular components. Moreover, some flavonoids exhibit anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines, such as TNF-α and IL-6.

Furthermore, flavonoids can modulate cell growth and apoptosis. Some flavonoids have been shown to induce apoptosis in cancer cells, leading to their elimination. Others can inhibit angiogenesis, the formation of new blood vessels, which is crucial for tumor growth.

In addition to these direct effects, flavonoids can also interact with other signaling pathways, such as the MAPK and PI3K/AKT pathways. These pathways are involved in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. By modulating these pathways, flavonoids can indirectly influence cellular function.

Overall, the cellular response to flavonoids is a multifaceted process that involves a complex interplay between various signaling pathways and cellular targets. The specific response can vary depending on the type of flavonoid, the cell type, and the concentration of the flavonoid. Further research is needed to fully understand the molecular mechanisms underlying the biological effects of flavonoids and to develop novel therapeutic strategies based on their unique properties.'
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Proteins (1)

Compounds (15)