AGN 191659: a retinoid x receptor pan-agonist; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6366726 |
| CHEMBL ID | 91718 |
| SCHEMBL ID | 3688709 |
| SCHEMBL ID | 3688713 |
| MeSH ID | M0356924 |
| Synonym |
|---|
| CHEMBL91718 , |
| bdbm50032220 |
| 5-[(e)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-thiophene-2-carboxylic acid |
| agn 191659 |
| (e)-5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-2-thiophenecarboxylic acid |
| acf4f9h44i , |
| 156691-86-0 |
| unii-acf4f9h44i |
| 5-[(e)-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]thiophene-2-carboxylic acid |
| indralin |
| SCHEMBL3688709 |
| SCHEMBL3688713 |
| QPAMXNZWXFZISY-SDNWHVSQSA-N |
| 5-[(e)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalen-2-yl)propen-1-yl]-2-thiophenecarboxylic acid |
| 5-((e)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalen-2-yl)propen-1-yl)-2-thiophenecarboxylic acid |
| agn-191659 |
| 5-((1e)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propen-1-yl)-2-thiophenecarboxylic acid |
| 260243-35-4 |
| 2-thiophenecarboxylic acid, 5-((1e)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propen-1-yl)- |
| indraline |
| PD085070 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "4 GHz, specific absorption rate 90-100 W/kg) was studied." | ( [Protective action of mexamine and indralin in intensive electromagnetic irradiation of rats]. Davydov, BI; Soldatov, SK; Ushakov, IB; Zuev, VG, ) | 0.13 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor alpha | Homo sapiens (human) | EC50 (µMol) | 0.0000 | 0.0002 | 0.1790 | 2.5119 | AID200108 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC50 (µMol) | 0.0230 | 0.0003 | 0.2311 | 6.9000 | AID198201 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC50 (µMol) | 0.0370 | 0.0002 | 0.0613 | 0.6480 | AID198713 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 (µMol) | 0.0110 | 0.0001 | 0.3427 | 9.1000 | AID199477 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID81281 | Transglutaminase activity in HL-60 cdm-1 cells | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID139988 | In vitro inhibition of chondrogenesis in mouse embryo limb bud cells | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID200108 | Transcriptional activation of Retinoic acid receptor RAR alpha | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID198201 | Transcriptional activation of Retinoic acid receptor RAR beta | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID114618 | Inhibition of tumor-promoter-induced ornithine decarboxylase in TPA-treated female hairless mice | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID199477 | Transcriptional activation of Retinoid X receptor RXR alpha | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID198713 | Transcriptional activation of Retinoic acid receptor RAR gamma | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.90) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (4.65%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 41 (95.35%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||