Compounds > glucopiericidin a
Page last updated: 2024-12-11

glucopiericidin a

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Description

glucopiericidin A: from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44608046
CHEMBL ID4092369
MeSH IDM0148539

Synonyms (4)

Synonym
glucopiericidin a
108073-65-0
bdbm50504090
CHEMBL4092369 ,
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)IC50 (µMol)0.00490.00492.99549.9920AID1425906
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Peroxiredoxin-1Homo sapiens (human)Kd1.83001.83002.22002.6100AID1516530
Oxysterols receptor LXR-alphaHomo sapiens (human)Kd3,492,000.00000.09243.12566.9700AID1812739
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (71)

Processvia Protein(s)Taxonomy
central nervous system developmentSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
transport across blood-brain barrierSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
response to hypoxiaSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
female pregnancySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
long-chain fatty acid import across plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
L-ascorbic acid metabolic processSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cerebral cortex developmentSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cellular response to glucose starvationSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
xenobiotic transportSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
photoreceptor cell maintenanceSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
protein-containing complex assemblySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cellular response to mechanical stimulusSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cellular hyperosmotic responseSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
glucose import across plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
transport across blood-brain barrierSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
response to Thyroglobulin triiodothyronineSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
glucose transmembrane transportSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
glucose importSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
response to insulinSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
dehydroascorbic acid transportSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
hydrogen peroxide catabolic processPeroxiredoxin-1Homo sapiens (human)
skeletal system developmentPeroxiredoxin-1Homo sapiens (human)
canonical NF-kappaB signal transductionPeroxiredoxin-1Homo sapiens (human)
cell population proliferationPeroxiredoxin-1Homo sapiens (human)
natural killer cell activationPeroxiredoxin-1Homo sapiens (human)
regulation of stress-activated MAPK cascadePeroxiredoxin-1Homo sapiens (human)
erythrocyte homeostasisPeroxiredoxin-1Homo sapiens (human)
natural killer cell mediated cytotoxicityPeroxiredoxin-1Homo sapiens (human)
hydrogen peroxide catabolic processPeroxiredoxin-1Homo sapiens (human)
fibroblast proliferationPeroxiredoxin-1Homo sapiens (human)
regulation of non-canonical NF-kappaB signal transductionPeroxiredoxin-1Homo sapiens (human)
removal of superoxide radicalsPeroxiredoxin-1Homo sapiens (human)
cell redox homeostasisPeroxiredoxin-1Homo sapiens (human)
leukocyte activationPeroxiredoxin-1Homo sapiens (human)
response to oxidative stressPeroxiredoxin-1Homo sapiens (human)
cellular response to stressPeroxiredoxin-1Homo sapiens (human)
negative regulation of transcription by RNA polymerase IIOxysterols receptor LXR-alphaHomo sapiens (human)
hormone-mediated signaling pathwayOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of macrophage derived foam cell differentiationOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of triglyceride biosynthetic processOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of cholesterol effluxOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of cholesterol storageOxysterols receptor LXR-alphaHomo sapiens (human)
intracellular receptor signaling pathwayOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of lipid transportOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of cholesterol transportOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of transporter activityOxysterols receptor LXR-alphaHomo sapiens (human)
response to progesteroneOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of toll-like receptor 4 signaling pathwayOxysterols receptor LXR-alphaHomo sapiens (human)
phosphatidylcholine acyl-chain remodelingOxysterols receptor LXR-alphaHomo sapiens (human)
cholesterol homeostasisOxysterols receptor LXR-alphaHomo sapiens (human)
regulation of circadian rhythmOxysterols receptor LXR-alphaHomo sapiens (human)
mRNA transcription by RNA polymerase IIOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of macrophage activationOxysterols receptor LXR-alphaHomo sapiens (human)
apoptotic cell clearanceOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of fatty acid biosynthetic processOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of proteolysisOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of DNA-templated transcriptionOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of lipid biosynthetic processOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of pinocytosisOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of inflammatory responseOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of lipoprotein lipase activityOxysterols receptor LXR-alphaHomo sapiens (human)
positive regulation of protein metabolic processOxysterols receptor LXR-alphaHomo sapiens (human)
lipid homeostasisOxysterols receptor LXR-alphaHomo sapiens (human)
sterol homeostasisOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of type II interferon-mediated signaling pathwayOxysterols receptor LXR-alphaHomo sapiens (human)
triglyceride homeostasisOxysterols receptor LXR-alphaHomo sapiens (human)
cellular response to lipopolysaccharideOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of pancreatic juice secretionOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of secretion of lysosomal enzymesOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of cold-induced thermogenesisOxysterols receptor LXR-alphaHomo sapiens (human)
negative regulation of response to endoplasmic reticulum stressOxysterols receptor LXR-alphaHomo sapiens (human)
cell differentiationOxysterols receptor LXR-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (22)

Processvia Protein(s)Taxonomy
long-chain fatty acid transmembrane transporter activitySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
glucose transmembrane transporter activitySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
protein bindingSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
kinase bindingSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
dehydroascorbic acid transmembrane transporter activitySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
identical protein bindingSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
xenobiotic transmembrane transporter activitySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
D-glucose transmembrane transporter activitySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
RNA bindingPeroxiredoxin-1Homo sapiens (human)
peroxidase activityPeroxiredoxin-1Homo sapiens (human)
protein bindingPeroxiredoxin-1Homo sapiens (human)
thioredoxin peroxidase activityPeroxiredoxin-1Homo sapiens (human)
identical protein bindingPeroxiredoxin-1Homo sapiens (human)
cadherin bindingPeroxiredoxin-1Homo sapiens (human)
transcription cis-regulatory region bindingOxysterols receptor LXR-alphaHomo sapiens (human)
transcription cis-regulatory region bindingOxysterols receptor LXR-alphaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificOxysterols receptor LXR-alphaHomo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificOxysterols receptor LXR-alphaHomo sapiens (human)
DNA bindingOxysterols receptor LXR-alphaHomo sapiens (human)
nuclear receptor activityOxysterols receptor LXR-alphaHomo sapiens (human)
protein bindingOxysterols receptor LXR-alphaHomo sapiens (human)
zinc ion bindingOxysterols receptor LXR-alphaHomo sapiens (human)
cholesterol bindingOxysterols receptor LXR-alphaHomo sapiens (human)
chromatin DNA bindingOxysterols receptor LXR-alphaHomo sapiens (human)
sterol response element bindingOxysterols receptor LXR-alphaHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingOxysterols receptor LXR-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
Golgi membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
female germ cell nucleusSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
photoreceptor inner segmentSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
female pronucleusSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cytosolSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
caveolaSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
intercalated discSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
basolateral plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
apical plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
Z discSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
midbodySolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
cortical actin cytoskeletonSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
sarcolemmaSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
melanosomeSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
extracellular exosomeSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
blood microparticleSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
presynapseSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
glucose transporter complexSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
apical plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
basolateral plasma membraneSolute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)
extracellular spacePeroxiredoxin-1Homo sapiens (human)
nucleusPeroxiredoxin-1Homo sapiens (human)
cytoplasmPeroxiredoxin-1Homo sapiens (human)
cytosolPeroxiredoxin-1Homo sapiens (human)
melanosomePeroxiredoxin-1Homo sapiens (human)
extracellular exosomePeroxiredoxin-1Homo sapiens (human)
cytosolPeroxiredoxin-1Homo sapiens (human)
nucleusOxysterols receptor LXR-alphaHomo sapiens (human)
nucleoplasmOxysterols receptor LXR-alphaHomo sapiens (human)
cytoplasmOxysterols receptor LXR-alphaHomo sapiens (human)
cytosolOxysterols receptor LXR-alphaHomo sapiens (human)
RNA polymerase II transcription regulator complexOxysterols receptor LXR-alphaHomo sapiens (human)
chromatinOxysterols receptor LXR-alphaHomo sapiens (human)
receptor complexOxysterols receptor LXR-alphaHomo sapiens (human)
nucleusOxysterols receptor LXR-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (106)

Assay IDTitleYearJournalArticle
AID1516507Down regulation of EGFR mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812719Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as fold increase in LXRalpha mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516517Antioxidant activity in human ACHN cells harboring shPRDX1 gene assessed as reduction in reactive oxygen species level at 25 to 50 nM measured after 24 hrs by Cell-rox reagent-based flow cytometry2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812688Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 5 uM measured after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry (Rvb = 15.5 %)2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812722Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as decrease in Car mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812736Down regulation of Cyp7a1 mRNA expression level in human HepG2 cells at 1 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516511Down regulation of SLC2A1 mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812669Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as fold increase in plasma AST at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812716Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as inhibition of Cyp7a1 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812689Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 5 uM measured after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry (Rvb = 0 %)2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812703Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as fold increase in plasma LDL-cholesterol level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812676Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as inflammatory infiltration at 0.8 mg/kg, ip by histological analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516516Activation of PRDX1 in human ACHN cells assessed as reduction in reactive oxygen species level at 25 to 50 nM measured after 24 hrs by Cell-rox reagent-based flow cytometry2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812664Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on visceral coefficient of liver at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812678Induction of histopathological changes in HCD-fed C57BL/6 mouse assessed as white discoloration of liver at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516505Cytotoxicity against human HK2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812718Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as change in Ugt1a1 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812730Induction of FXR mRNA level in human HepG2 cells assessed as fold increase in FXR expression at 1 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812701Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as fold increase in liver total bile acid level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812709Induction of LDLR protein expression level in HCD-fed C57BL/6 mouse at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812731Induction of SHP mRNA level in human HepG2 cells assessed as fold increase in SHP expression at 1 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516504Cytotoxicity against human 786-O cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812695Induction of histopathological changes in HCD-fed C57BL/6 mouse assessed as striking subcapsular foci at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812708Induction of LDLR protein expression level in chow diet fed C57BL/6 mouse at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516531Antitumor activity against human ACHN cells xenografted in Balb/c nu/nu mouse assessed as tumor weight at 0.8 mg/kg, ip administered once daily for 21 days measured post-last dose by caliper method (Rvb = 0.55 +/- 0.13 g)2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516512Down regulation of LDHA mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812670Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as liver swelling at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812680Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as change in IL-6 level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812686Induction of mitochondrial dysfunction in human HepG2 cells assessed as increase in ROS production at 0.1 to 5 uM after 48 hrs by flow cytometric analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516540Antitumor activity against human ACHN cells xenografted in Balb/c nu/nu mouse assessed as tumor growth inhibition at 0.8 mg/kg, ip administered once daily for 21 days measured post-last dose by H and E staining-based assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516506Cytotoxicity against human ACHN cells harboring shPRDX1 gene assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812694Induction of hepatic pathological changes in normal chow diet fed C57BL/6 mouse at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812668Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as fold increase in plasma ALT at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516533Toxicity in Balb/c nu/nu mouse xenografted with human ACHN cells assessed as effect on survival at 0.8 mg/kg, ip administered once daily for 21 days2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516527Selectivity ratio of IC50 for cytotoxicity against human ACHN cells harboring shPRDX1 gene to IC50 for Cytotoxicity against human ACHN cells2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812739Binding affinity to full-length human LXRalpha by surface plasmon resonance assay2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812687Induction of apoptosis in human HepG2 cells assessed as live cells at 5 uM measured after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry (Rvb = 84.5 %)2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812717Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as inhibition of Cyp8b1 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516528Up regulation of nuclear PRDX1 expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by immunoblot analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812693Induction of calcium signal in human HepG2 cells at 5 uM by Fluo-4AM dye based fluorescence assay2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812735Down regulation of LXRalpha protein level in human HepG2 cells at 1 to 5 uM by Western blot analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812666Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on visceral coefficient of lung at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812721Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as change in Ppar-alpha mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812700Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as fold increase in liver total cholesterol level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516538Up regulation of PRDX1 mRNA expression in human ACHN cells xenografted Balb/c nu/nu mouse at 0.8 mg/kg, ip administered once daily for 21 days measured post-last dose by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516510Down regulation of HK2 mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812737Down regulation of Cyp7a1 mRNA expression level in human HepG2 cells at 5 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812681Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as change in IL-1beta level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812663Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on visceral coefficient of heart at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812682Induction of Cholesterol accumulation in human HepG2 cells assessed as fold increase in LDL-cholesterol level at 5 uM after 48 hrs2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812705Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as fold increase in plasma total bile acid level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812715Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as change in Mrp2 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812743Toxicity in mouse assessed as death at 10 mg/kg, po after 45 mins2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812684Induction of mitochondrial dysfunction in human HepG2 cells assessed as decrease in ILbeta level at 5 to 10 uM after 48 hrs2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812723Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as change in Car protein expression2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812677Toxicity in renal carcinoma xenografted C57BL/6 mouse kidney assessed as change in CRE level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812699Toxicity in HCD-fed C57BL/6 mouse assessed as fold increase in AST level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812706Reversal of HCD-induced LXRalpha activation in C57BL/6 mouse assessed as decrease in LXRalpha protein level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812729Down regulation of SHP mRNA level in human HepG2 cells at 5 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812690Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 5 uM measured after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry (Rvb = 0 %)2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812674Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as large scale necrotic foci at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812662Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on body weight at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516535Toxicity in Balb/c nu/nu mouse xenografted with human ACHN cells assessed as decrease in body weight at 0.8 mg/kg, ip administered once daily for 21 days2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516529Induction of PRDX1 nuclear translocation in human ACHN cells at 25 to 50 nM measured after 24 hrs by DAPI staining-based microscopic analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812720Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as reversal of LXRbeta mRNA upregulation by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812704Down regulation of ABCB1 protein level in human HepG2 cells at 1 to 5 uM by Western blot analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812697Toxicity in HCD-fed C57BL/6 mouse assessed as body weight loss at 0.8 mg/kg, ip measured on day 282021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812738Cmax in mouse at 10 mg/kg, po by LC-MS/MS analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812733Induction of LDLR mRNA level in human HepG2 cells assessed as fold increase in LDLR expression at 5 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516508Down regulation of SOD2 mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812702Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as fold increase in liver LDL-cholesterol level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516514Down regulation of HIF1A mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516509Down regulation of ETS1 mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516503Cytotoxicity against human OS-RC2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812661Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as decrease in FXR mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812710Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as reduction in Ntcp-mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812711Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as down regulation of Oatp1 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812665Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on visceral coefficient of spleen at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812696Induction of histopathological changes in HCD-fed C57BL/6 mouse assessed as swelling gallbladder size at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812672Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as liver necrosis at 0.8 mg/kg, ip by histological analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812707Inhibition of FXR protein expression level in HCD-fed C57BL/6 mouse at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812712Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as down regulation of Ost-alpha mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812675Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as appearance of pyknotic nucleus at 0.8 mg/kg, ip by histological analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812692Induction of mitochondrial membrane potential loss in human HepG2 cells assessed as intact mitochondrial membrane potential at 5 uM after 48 hrs by TMRM dye based flow cytometric analysis (Rvb = 74.2%)2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812667Toxicity in renal carcinoma xenografted C57BL/6 mouse assessed as effect on visceral coefficient of kidney at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516513Down regulation of MET mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516530Binding affinity to full-length human PRDX1 by surface plasmon resonance analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812713Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as fold increase in Mrp3 mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516502Cytotoxicity against human ACHN cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516537Up regulation of PRDX1 expression in human ACHN cells xenografted Balb/c nu/nu mouse at 0.8 mg/kg, ip administered once daily for 21 days measured post-last dose by immunoblot analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812740Drug concentration in mouse liver at 10 mg/kg, po after 30 mins by LC-MS/MS analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812673Induction of HCD-induced cholestasis in C57BL/6 mouse assessed as lipid accumulation in liver at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812742Drug metabolism in mouse liver assessed as PA formation at 10 mg/kg, po after 30 mins by LC-MS/MS analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812732Induction of LDLR mRNA level in human HepG2 cells assessed as fold increase in LDLR expression at 1 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1425906Inhibition of GLUT1 in human A431 cells assessed as reduction in 2-[1,2-3H]deoxy-D-glucose uptake measured after 30 mins by liquid scintillation counting method2016MedChemComm, Sep-01, Volume: 7, Issue:9
Anticancer agents interacting with membrane glucose transporters.
AID1812724Effect on bile acid homeostasis in Chow diet-fed C57BL/6 mouse assessed as change in Car protein expression2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812714Effect on bile acid homeostasis in HCD-fed C57BL/6 mouse assessed as change in Bsep mRNA expression by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812671Hepatotoxicity in renal carcinoma xenografted C57BL/6 mouse assessed as white discoloration of liver at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812741Drug metabolism in mouse liver assessed as PA formation at 10 mg/kg, po after 180 mins by LC-MS/MS analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1516515Up regulation of PRDX1 mRNA expression in human ACHN cells at 25 to 50 nM measured after 24 hrs by qRT-PCR analysis2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1516539Antitumor activity against human ACHN cells xenografted in Balb/c nu/nu mouse assessed as tumor growth inhibition at 0.8 mg/kg, ip administered once daily for 21 days measured post-last dose by TUNEL staining-based assay2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
AID1812679Toxicity in renal carcinoma xenografted C57BL/6 mouse kidney assessed as change in BUN level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812734Effect on LXRalpha mRNA level in human HepG2 cells at 1 to 5 uM by RT-qPCR analysis2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812725Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at < 10 uM incubated for 48 hrs by MTT assay2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812691Induction of apoptosis in human HepG2 cells assessed as change in caspase 3 protein expression at 1 to 5 uM after 48 hrs2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
AID1812698Toxicity in HCD-fed C57BL/6 mouse assessed as fold increase in ALT level at 0.8 mg/kg, ip2021Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's6 (66.67)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gossypol
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.		2.1310
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		1.9810amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
silybin
silibinin : A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.		2.1310aromatic ether;
benzodioxine;
flavonolignan;
polyphenol;
secondary alpha-hydroxy ketone		antineoplastic agent;
antioxidant;
hepatoprotective agent;
plant metabolite
atorvastatin
[no description available]		2.3110aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic)		environmental contaminant;
xenobiotic
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		1.9710D-glucopyranoseepitope;
mouse metabolite
sorafenib
[no description available]		2.6620(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.1310(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
gw 3965
GW 3965: a liver X receptor ligand		2.3110diarylmethane
xanthohumol
xanthohumol: from hop plant, Humulus lupulus. xanthohumol : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.		2.1310aromatic ether;
chalcones;
polyphenol		anti-HIV-1 agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor;
metabolite
stf-31
STF-31: antineoplastic		2.1310
quercetin
[no description available]		2.13107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol
[no description available]		2.13107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein
[no description available]		2.13107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
myricetin
[no description available]		2.13107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
piericidin a
piericidin A: pyridine-substituted fatty alcohol antibiotic; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (S-(R*,R*-(all-E)))-isomer. piericidin A : A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase		3.1650aromatic ether;
methylpyridines;
monohydroxypyridine;
secondary allylic alcohol		antimicrobial agent;
bacterial metabolite;
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor;
mitochondrial respiratory-chain inhibitor
terpestacin
terpestacin: structure given in first source; isolated from Arthrinium; inhibits syncytium (giant cell) formation		3.2310secondary alcohol
cryptocaryone
cryptocaryone: inhibitor of the NF-kappaB activation pathway from Cryptocarya rugulosa; structure in first source		2.1310benzofurans
wzb117
WZB117: structure in first source		2.1310
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylate
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate: inhibits lactate dehydrogenase A; structure in first source		2.1310
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		1.9810
ecumicin
ecumicin: antitubercular from Nonomuraea sp. MJM5123; structure in first source		3.2310
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma Of Kidney
[description not available]		02.2110
Cancer of Kidney
[description not available]		02.2110
Carcinoma, Renal Cell
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.		02.2110
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.2110
Pleuropericarditis
Inflammation of both the PERICARDIUM and the PLEURA.		02.3110
Pericarditis
Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.		02.3110
Benign Neoplasms
[description not available]		03.0310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0310
Carcinoma, Anaplastic
[description not available]		01.9810
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9810