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EC 2.3.3.8 (ATP citrate synthase) inhibitor

An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of ATP citrate synthase (EC 2.3.3.8).

ChEBI ID: 149598

Members (2)

MemberDefinitionClass
etc-1002An alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'.bempedoic acid
medica 16An alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.MEDICA 16

Research

Studies (209)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19907 (3.35)18.7374
1990's14 (6.70)18.2507
2000's9 (4.31)29.6817
2010's34 (16.27)24.3611
2020's145 (69.38)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials25 (10.78%)5.53%
Reviews76 (32.76%)6.00%
Case Studies2 (0.86%)4.05%
Observational1 (0.43%)0.25%
Other128 (55.17%)84.16%

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency63.095711
DNA polymerase kappa isoform 1Homo sapiens (human)Potency37.685811
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency35.481311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-citrate synthase Rattus norvegicus (Norway rat)Ki11.666733