Page last updated: 2024-08-05 15:37:56

EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor

An EC 6.4.1.* (C-C bond-forming ligase) inhibitor that interferes with the action of acetyl-CoA carboxylase (EC 6.4.1.2).

ChEBI ID: 70722

Members (9)

MemberDefinitionClass
2-(4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy)-2'-fluoro-n-methylpropionanilideA 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide that has R-configuration. It is an inhibitor of acetyl-coenzyme A carboxylase (ACCase) and a postemergence herbicide which exhibits high control efficacy against sensitive weeds, especially Echinochloa crus-galli in paddy fields.metamifop
5-(tetradecyloxy)-2-furancarboxylic acidA member of the class of furans that is 2-furoic acid in which the hydrogen at position 5 is replaced by a tetradecyloxy group.5-(tetradecyloxy)-2-furoic acid
9-oxononanoic acidA medium-chain oxo-fatty acid that is the 9-oxo derivative of nonanoic acid.9-oxononanoic acid
clodinafopAn aromatic ether that is (R)-lactic acid in which the hydroxy group at position 2 has been converted to the corresponding p-[(5-chloro-3-fluoropyridin-2-yl)oxy]phenyl ether. It is the parent acid of the herbicide clodinafop-propargyl.clodinafop
clodinafop-propargylA carboxylic ester resulting from the formal condensation of the carboxy group of clodinafop with the hydroxy group of prop-2-yn-1-ol. It is widely used as a herbicide for the control of annual grass weeds in cereal crops.clodinafop-propargyl
haloxyfop-P-methylA methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate that has R configuration. It is a proherbicide (by hydrolysis of the methyl ester) for the herbicide haloxyfop-P, the most active enantiomer of the racemic herbicide haloxyfop.haloxyfop-P-methyl
medica 16An alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.MEDICA 16
pinoxadenA pyrazolooxadiazepine that is 7-oxo-1,2,4,5-tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin which is substituted at positions 8 and 9 by 2,6-diethyl-4-methylphenyl and pivaloyloxy groups, respectively. A pro-herbicide (by hydrolysis of the pivalate ester to give the corresponding enol), it is used for control of grass weeds in cereal crops.pinoxaden
soraphen aA macrolide and an agent highly effective against plant-pathogenic fungi. It was extensively researched for agricultural use until it was discovered to be a teratogen.soraphen A

Research

Studies (203)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199027 (13.30)18.7374
1990's24 (11.82)18.2507
2000's52 (25.62)29.6817
2010's74 (36.45)24.3611
2020's26 (12.81)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (2.28%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other214 (97.72%)84.16%

Protein Targets (20)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency0.435823
Chain A, Ferritin light chainEquus caballus (horse)Potency11.220211
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency25.118911
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency40.953023
DNA polymerase kappa isoform 1Homo sapiens (human)Potency24.801612
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.299133
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency23.504822
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.796122
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency23.445112
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency38.570811
pregnane X nuclear receptorHomo sapiens (human)Potency70.794611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency33.878222
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.007911
thyroid stimulating hormone receptorHomo sapiens (human)Potency8.591011
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.810822
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.002811
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency23.350712

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-citrate synthase Rattus norvegicus (Norway rat)Ki11.666733

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Acetyl-CoA carboxylase 2Homo sapiens (human)Kd0.001011