An inhibitor that interferes with the process of T-cell proliferation.
ChEBI ID: 63173
| Member | Definition | Class |
|---|---|---|
| savinin | A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2. | savinin |
| sphingosine 1-phosphate | A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 | sphingosine 1-phosphate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.03) | 18.7374 |
| 1990's | 180 (4.79) | 18.2507 |
| 2000's | 1,246 (33.15) | 29.6817 |
| 2010's | 1,804 (47.99) | 24.3611 |
| 2020's | 528 (14.05) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 23 (0.60%) | 5.53% |
| Reviews | 745 (19.54%) | 6.00% |
| Case Studies | 2 (0.05%) | 4.05% |
| Observational | 10 (0.26%) | 0.25% |
| Other | 3,033 (79.54%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.0022 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 25.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 25.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 25.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 25.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 25.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | IC50 | 0.0008 | 6 | 6 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | IC50 | 0.0019 | 4 | 4 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | IC50 | 0.0004 | 6 | 6 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | IC50 | 0.0522 | 7 | 7 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | IC50 | 0.0020 | 5 | 5 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 25.0000 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 25.0000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Homo sapiens (human) | EC50 | 0.0011 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | EC50 | 0.0067 | 15 | 15 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | EC50 | 0.0097 | 7 | 7 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | EC50 | 0.0087 | 13 | 13 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | EC50 | 0.1270 | 6 | 6 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | EC50 | 0.0235 | 8 | 8 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | AC50 | 0.2430 | 1 | 1 |