Page last updated: 2024-11-12
chamaechromone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Description
chamaechromone: an anti-hepatitis B virus agent isolated from Stellera chamaejasme; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Stellera | genus | [no description available] | Thymelaeaceae | A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 12084958 |
MeSH ID | M0561088 |
Synonyms (8)
Synonym |
---|
93413-00-4 |
chamaechromone |
3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxychromen-4-one |
MS-29984 |
HY-133721 |
CS-0129965 |
3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxy-4h-chromen-4-one |
AKOS040760320 |
Research Excerpts
Overview
Chamaechromone is a major component in the dried roots of Stellera chamaejasme with antihepatitis B virus and insecticidal activity.
Excerpt | Reference | Relevance |
---|---|---|
"Chamaechromone is a major component in the dried roots of Stellera chamaejasme with antihepatitis B virus and insecticidal activity. " | ( Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes. Hu, H; Lou, Y; Qiu, Y; Wang, L; Zeng, S; Zhang, X; Zheng, J, 2014) | 2.21 |
Pharmacokinetics
Excerpt | Reference | Relevance |
---|---|---|
" This method was successfully applied to a pharmacokinetic study of chamaechromone in rats after intravenous (5mg/kg) and oral (100mg/kg) administration." | ( Determination of chamaechromone in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study. Hu, H; Jiang, H; Li, L; Liu, Y; Lou, Y; Ping, L; Yu, L; Yu, Q; Zeng, S, 2011) | 0.94 |
Compound-Compound Interactions
Excerpt | Reference | Relevance |
---|---|---|
"91%, respectively), were separated by semi-preparative high-performance liquid chromatography combined with high-speed counter-current chromatography." | ( Development of a method to screen and isolate bioactive constituents from Stellera chamaejasme by ultrafiltration and liquid chromatography combined with semi-preparative high-performance liquid chromatography and high-speed counter current chromatography Hou, W; Huang, Y; Li, S; Liu, C; Wu, T; Xia, J, 2019) | 0.51 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" In addition, the influence of NCB on the bioavailability of chamaechromone following their co-administration was also determined in rats." | ( Neochamaejasmin B increases the bioavailability of chamaechromone coexisting in Stellera chamaejasme L. via inhibition of MRP2 and BCRP. Bi, H; Hu, H; Huang, M; Lou, Y; Pan, L; Wang, X; Zeng, K; Zeng, S, 2015) | 0.91 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (8)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 8 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |