Gene Targets > D-glucose transmembrane transporter activity
Page last updated: 2024-10-24

D-glucose transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:jid, GOC:jsg, GOC:mah]

D-glucose transmembrane transporter activity refers to the movement of D-glucose across the cell membrane. This process is crucial for cellular energy production, as glucose is the primary fuel source for many cells. D-glucose transmembrane transporters are integral membrane proteins that facilitate the passive or active transport of glucose down or against its concentration gradient, respectively. In passive transport, glucose moves from an area of high concentration to an area of low concentration, driven by the concentration gradient. In active transport, energy is required to move glucose against its concentration gradient, often using ATP as the energy source. These transporters exhibit high specificity for D-glucose, distinguishing it from other sugars. They play a vital role in various physiological processes, including nutrient uptake, glucose homeostasis, and energy metabolism.'
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Proteins (7)

ProteinDefinitionTaxonomy
Solute carrier family 2, facilitated glucose transporter member 1A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11166]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 4A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14672]Homo sapiens (human)
Sodium/glucose cotransporter 2A sodium/glucose cotransporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31639]Homo sapiens (human)
Sodium/glucose cotransporter 1A sodium/glucose cotransporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13866]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 3A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11169]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 2A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11168]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 1A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11166]Homo sapiens (human)

Compounds (40)

CompoundDefinitionClassesRoles
gossypolGossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
phloretindihydrochalconesantineoplastic agent;
plant metabolite
phlorhizinaryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative		antioxidant;
plant metabolite
cytidinecytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cycloheximidecycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.

Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.		antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
emetineemetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.

Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.		isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
c 137C 137: RN given refers to parent cpd
imidocarbImidocarb: One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.ureasantiprotozoal drug
colforsinColforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
vexibinolsophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'.

vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R*,S*))-isomer		(2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone		antimalarial;
antimicrobial agent;
antioxidant;
plant metabolite
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylenediarylmethane
mmv665852MMV665852: an antischistosomal agent
1,3,4,10-Tetrahydro-9(2H)-acridinoneacridines
anisomycin(-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.		monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor
jp-1302
1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamineaminoquinoline
2',4',6'-Trihydroxydihydrochalconechalcones
polysulfide rubber
2-[2-methoxyethyl-(1-oxo-2-thiophen-2-ylethyl)amino]-N-[(4-methoxyphenyl)methyl]-2-(4-propan-2-ylphenyl)acetamidemonoterpenoid
quercetin7-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
myricetin7-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
cytochalasin bcytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.

Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.		cytochalasin;
lactam;
lactone;
organic heterotricyclic compound		actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
pd 166285
pd-173952
2',4',6'-trihydroxychalconepinocembrin chalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively.

pinocembrin chalcone: isolated from Helichrysum trilineatum; structure in first source		chalconesantifungal agent;
plant metabolite
sergliflozin etabonatesergliflozin: a hypoglycemic agent that inhibits SGLT2 sodium-glucose transporter; structure in first sourceglycoside
remogliflozin etabonateremogliflozin etabonate: orally administered hypoglycemic agent; structure in first sourceglycoside
dapagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
ipragliflozinglycoside
empagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitoldiarylmethane
nothofaginnothofagin: a dihydrochalcone
canagliflozincanagliflozin hydrate : A hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.C-glycosyl compound;
organofluorine compound;
thiophenes		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
glucopiericidin aglucopiericidin A: from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic
pf 04971729ertugliflozin: structure in first sourcediarylmethane
wzb117WZB117: structure in first source
deberza2-benzofurans
hesperadin
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