| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID711111 | Binding affinity to wild type human CK1delta (1-294 amino acids) assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID711105 | Binding affinity to human CK1epsilon K69R mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID684969 | Inhibition of CK1delta | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. |
| AID646404 | Inhibition of human CK1epsilon expressed in Escherichia coli BL21 using PLSRTLpSVASLPGL as substrate after 3 hrs by KinaseGlo assay | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. |
| AID767006 | Inhibition of EGFR (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID1375064 | Inhibition of CK1delta isolated from human PANC1 cells at 125 uM using GST-tagged p53 (1 to 64 residues) as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
| AID711110 | Binding affinity to human CK1delta T67S mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID767014 | Inhibition of human CK1 delta transfected in african green monkey cos7 cells after overnight incubation by whole cell assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID684970 | Inhibition of CK1epsilon | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. |
| AID767009 | Inhibition of MAP4K4 (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID1337184 | Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID1539770 | Inhibition of human CK1delta in presence of [gamma33P]-ATP | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | Small molecule modulators targeting protein kinase CK1 and CK2. |
| AID711112 | Binding affinity to human CK1delta I55F mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID711115 | Inhibition of Casein kinase 1 epsilon | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID1733440 | Inhibition of full-length human CK1epsilon expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate incubated for 3 hrs in presence of ATP by Kinase-Glo luminescence assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems. |
| AID767024 | fCmax in C57Bl/6J mouse plasma at 32 mg/kg, sc by LC/MS analysis | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID1539769 | Inhibition of human CK1epsilon in presence of [gamma33P]-ATP | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | Small molecule modulators targeting protein kinase CK1 and CK2. |
| AID646405 | Inhibition of p38alpha | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. |
| AID767026 | Inhibition of human ERG channel by electrophysiological method | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID711114 | Inhibition of Casein kinase 1 delta | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID767027 | fCmax in C57Bl/6J mouse brain at 32 mg/kg, sc by LC/MS analysis | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID646403 | Inhibition of human recombinant CK1delta expressed in Escherichia coli using PLSRTLpSVASLPGL as substrate after 2 hrs by KinaseGlo assay | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. |
| AID1337183 | Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID646402 | Inhibition of EGFR | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. |
| AID711108 | Binding affinity to wild type human CK1epsilon (1-294 amino acids) assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID767012 | Inhibition of PKA alpha (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID767008 | Inhibition of LCK (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID767015 | Inhibition of CK1 epsilon (unknown origin) using PLSRTLpSVASLPGL as substrate after 85 mins by microplate reader analysis | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID767010 | Inhibition of CK1 alpha (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID767017 | Displacement of [3H]dofetilide from human ERG channel | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID1733441 | Inhibition of full-length human CK1delta expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate incubated for 3 hrs in presence of ATP by Kinase-Glo luminescence assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems. |
| AID711106 | Binding affinity to human CK1epsilon S67T mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID711109 | Binding affinity to human CK1delta R69K mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID767016 | Inhibition of CK1 delta (unknown origin) using PLSRTLpSVASLPGL as substrate after 60 mins by microplate reader analysis | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID711107 | Binding affinity to human CK1epsilon F55I mutant assessed as change in melting temperature by differential scanning fluorimetry | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID767011 | Inhibition of p38 (unknown origin) at 1 uM | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID767013 | Inhibition of p38 (unknown origin) | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Ligand-protein interactions of selective casein kinase 1δ inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. |
| AID1345666 | Human casein kinase 1 epsilon (Casein kinase 1 (CK1) family) | 2007 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 322, Issue:2
| An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. |
| AID1345304 | Human mitogen-activated protein kinase 14 (p38 subfamily) | 2007 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 322, Issue:2
| An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. |
| AID1345629 | Human casein kinase 1 delta (Casein kinase 1 (CK1) family) | 2007 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 322, Issue:2
| An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. |
| AID1345502 | Human epidermal growth factor receptor (Type I RTKs: ErbB (epidermal growth factor) receptor family) | 2007 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 322, Issue:2
| An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |