Page last updated: 2024-12-07

laurdan

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Laurdan (6-dodecanoyl-2-dimethylaminonaphthalene) is a fluorescent dye that is commonly used to study membrane fluidity and organization in biological systems. It is synthesized through a multi-step process that involves coupling dodecanoic acid with 2-dimethylaminonaphthalene. Laurdan exhibits a unique property of exhibiting different fluorescence emission spectra depending on the polarity of its environment. In more fluid and less polar environments, Laurdan emits blue fluorescence, while in more rigid and polar environments, it emits green fluorescence. This sensitivity to membrane fluidity makes Laurdan a valuable tool for studying membrane dynamics, phase transitions, and the effects of various factors, including temperature, lipid composition, and the presence of proteins, on membrane organization. Laurdan is widely used in various research fields, such as cell biology, biophysics, and pharmacology, to investigate the role of membrane fluidity in cellular processes, drug delivery, and disease pathogenesis.'

laurdan: RN from CA Index Guide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID104983
SCHEMBL ID592846
MeSH IDM0180285

Synonyms (26)

Synonym
6-dodecanoyl-2-dimethylaminonaphthalene
laurdan
6-dodecanoyl-n,n-dimethyl-2-naphthylamine, suitable for fluorescence, >=97.0% (hplc)
74515-25-6
1-[6-(dimethylamino)naphthalen-2-yl]dodecan-1-one
6-dodecanoyl-n,n-dimethyl-2-naphthylamine
unii-y97fbl93vw
y97fbl93vw ,
1-dodecanone, 1-(6-(dimethylamino)-2-naphthalenyl)-
1-(6-(dimethylamino)-2-naphthalenyl)-1-dodecanone
2-(dimethylamino)-6-dodecanoylnaphthalene
n,n-dimethyl-6-dodecanoyl-2-naphthylamine
FT-0621105
AKOS015894729
SCHEMBL592846
DTXSID80225517
J-100120
mfcd00467560
1-(6-(dimethylamino)naphthalen-2-yl)dodecan-1-one
JHDGGIDITFLRJY-UHFFFAOYSA-N
Q15426238
2-[(5s)-2,4-dioxothiazolidin-5-yl]acetate
CS-0009992
AS-78851
HY-D0080
SB83730

Research Excerpts

Overview

Laurdan is a fluorescent probe sensitive to the increase of hydration in the lipid bilayer that accompanies the gel to liquid crystalline phase transition.

ExcerptReferenceRelevance
"Laurdan is a fluorescent probe that detects changes in membrane phase properties through its sensitivity to the polarity of its environment in the bilayer. "( Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order.
Bell, JD; Best, KB; Harris, FM, 2002
)
2.21
"Laurdan is a fluorescent probe sensitive to the increase of hydration in the lipid bilayer that accompanies the gel to liquid crystalline phase transition."( Phospholipid phase transitions in homogeneous nanometer scale bilayer discs.
McLean, MA; Shaw, AW; Sligar, SG, 2004
)
1.04

Effects

ExcerptReferenceRelevance
"Laurdan has little effect on the phase transition of DPPC vesicles at the concentration used in the sensor (0.67 mol%); concentrations up to 5.4 mol% only slightly lowered the melting temperature."( Perturbation of the chain melting transition of DPPC by galactose, agarose and Laurdan as determined by differential scanning calorimetry.
Abrams, SB; Yager, P, 1993
)
1.23
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (252)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's40 (15.87)18.2507
2000's79 (31.35)29.6817
2010's105 (41.67)24.3611
2020's28 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.74 (24.57)
Research Supply Index5.56 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index56.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews15 (5.79%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other244 (94.21%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]