Target type: biologicalprocess
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]
Response to peptide is a complex biological process that involves the recognition and binding of peptides by specific receptors, followed by a cascade of intracellular signaling events that lead to a variety of cellular responses. Peptides are short chains of amino acids that can act as signaling molecules, mediating a wide range of biological processes, including immune responses, cell growth and differentiation, and hormone regulation. The response to peptide begins with the binding of a peptide to its specific receptor. Receptors for peptides can be found on the surface of cells, in the cytoplasm, or in the nucleus. Upon binding to its receptor, the peptide triggers a series of intracellular signaling events that lead to the activation of specific genes and the production of proteins that mediate the cellular response. The specific cellular response to a peptide can vary depending on the type of peptide, the type of cell, and the context in which the peptide is encountered. For example, some peptides can stimulate the production of antibodies, while others can trigger cell growth or differentiation. In some cases, the response to peptide can lead to the activation of immune cells, such as T cells or B cells, which can then mediate an immune response against pathogens or foreign antigens. In other cases, the response to peptide can lead to the activation of intracellular signaling pathways that regulate cell growth, differentiation, or metabolism. Overall, response to peptide is a fundamental biological process that plays a crucial role in a variety of physiological processes. The diversity of peptides and their receptors, as well as the complexity of intracellular signaling pathways, contribute to the wide range of cellular responses that can be elicited by peptides.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Heat shock factor protein 1 | A heat shock factor protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00613] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| zm 336372 | N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide: an inhibitor of c-Raf; activates Raf-1; structure in first source | benzamides | |
| celastrol | monocarboxylic acid; pentacyclic triterpenoid | anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite | |
| quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
| chir-265 | aromatic ether | ||
| az-628 | AZ-628: a multikinase inhibitor; structure in first source | benzamides | |
| GDC-0879 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor | |
| plx4032 | aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide | antineoplastic agent; B-Raf inhibitor | |
| dabrafenib | 1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide | anticoronaviral agent; antineoplastic agent; B-Raf inhibitor | |
| tak-632 | TAK-632 : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively. | (trifluoromethyl)benzenes; aromatic ether; benzothiazoles; cyclopropylcarboxamide; monofluorobenzenes; nitrile; secondary carboxamide | antineoplastic agent; apoptosis inducer; B-Raf inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; necroptosis inhibitor |
| dinaciclib | pyrazolopyrimidine | ||
| n2-(1h-indazole-5-yl)-n6-methyl-3-nitropyridine-2,6-diamine | KRIBB11 : A member of the class of indazoles that is 1H-indazole substituted by a [6-(methylamino)-3-nitropyridin-2-yl]amino group at position 5. It is an inhibitor of heat shock factor 1 (IC50 = 1.2muM) and suppresses tumour growth in mouse xenograft models. N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine: a heat shock factor 1 antagonist; structure in first source |