Any agent that affects the transport of molecular entities across a biological membrane.
ChEBI ID: 38632
| Member | Definition | Class |
|---|---|---|
| fenamic acid | An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs. | fenamic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 40 (12.78) | 18.7374 |
| 1990's | 128 (40.89) | 18.2507 |
| 2000's | 88 (28.12) | 29.6817 |
| 2010's | 47 (15.02) | 24.3611 |
| 2020's | 10 (3.19) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.31%) | 5.53% |
| Reviews | 9 (2.78%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 314 (96.91%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 42.2395 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 8.4921 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.3793 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0001 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.7688 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.2404 | 2 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 28.8287 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 15.8489 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.7359 | 1 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.6310 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.6234 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.3788 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 0.4400 | 2 | 2 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 1.5100 | 2 | 2 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.0870 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1.2000 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0380 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Mus musculus (house mouse) | Ki | 0.0870 | 1 | 1 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | IC50 | 51.0000 | 1 | 1 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | Ki | 50.6903 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 68.0000 | 2 | 2 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |