Compounds > propolin c
Page last updated: 2024-12-09

propolin c

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Description

propolin C: a PAK1 inhibitor; from Taiwanese propolis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

nymphaeol A : A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy group at positions 5, 7, 3' and 4' and a geranyl group at position 6. Isolated from Macaranga tanarius and propolis collected in Okinawa, it exhibits radical scavenging activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
MacarangagenusA plant genus. Members contain mappain.[MeSH]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]
Macaranga tanariusspecies[no description available]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID SourceID
PubMed CID639465
CHEMBL ID223256
CHEBI ID66640
SCHEMBL ID7795014
SCHEMBL ID16105856
MeSH IDM0459871

Synonyms (15)

Synonym
(2s)-2-(3,4-dihydroxyphenyl)-6-[(2e)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2,3-dihydrochromen-4-one
4h-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-6-(3,7-dimethyl-2,6-octadienyl)-2,3-dihydro-5,7-dihydroxy-, (2s)-
2-(3,4-dihydroxyphenyl)-6-(3,7-dimethylocta-2,6-dien-1-yl)-5,7-dihydroxy-2,3-dihydro-4h-chromen-4-one
inchi=1/c25h28o6/c1-14(2)5-4-6-15(3)7-9-17-19(27)12-23-24(25(17)30)21(29)13-22(31-23)16-8-10-18(26)20(28)11-16/h5,7-8,10-12,22,26-28,30h,4,6,9,13h2,1-3h3/b15-7+/t22-/m0/s
chebi:66640 ,
nymphaeol a
CHEMBL223256
bdbm50380205
6-geranyl-3',4',5,7-tetrahydroxyflavanone
(2s)-2-(3,4-dihydroxyphenyl)-6-[(2e)-3,7-dimethylocta-2,6-dien-1-yl]-5,7-dihydroxy-2,3-dihydro-4h-chromen-4-one
SCHEMBL7795014
SCHEMBL16105856
73676-38-7
propolin c
Q27135257
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
radical scavengerA role played by a substance that can react readily with, and thereby eliminate, radicals.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
tetrahydroxyflavanoneA hydroxyflavanone with atleast four hydroxy substituents.
4'-hydroxyflavanonesAny hydroxyflavanone having a hydroxy substituent located at position 4'.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Prostaglandin G/H synthase 1Ovis aries (sheep)IC50 (µMol)1.80000.00032.177410.0000AID1424043
Neutrophil elastaseHomo sapiens (human)IC50 (µMol)22.80000.00632.073422.3780AID1502927
Neutrophil elastaseHomo sapiens (human)Ki15.70000.00201.28669.5499AID1502928
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC50 (µMol)0.05000.00011.68479.3200AID1424048
AcetylcholinesteraseHomo sapiens (human)IC50 (µMol)7.20000.00000.933210.0000AID654699
AcetylcholinesteraseHomo sapiens (human)Ki8.40000.00001.27869.7300AID654700
Prostaglandin G/H synthase 2Homo sapiens (human)IC50 (µMol)4.20000.00010.995010.0000AID1424044
Carboxylic ester hydrolase Equus caballus (horse)IC50 (µMol)1.40000.00512.69848.5000AID654701
Carboxylic ester hydrolase Equus caballus (horse)Ki1.20000.00200.95708.0000AID654839
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (123)

Processvia Protein(s)Taxonomy
proteolysisNeutrophil elastaseHomo sapiens (human)
negative regulation of transcription by RNA polymerase IINeutrophil elastaseHomo sapiens (human)
response to yeastNeutrophil elastaseHomo sapiens (human)
leukocyte migration involved in inflammatory responseNeutrophil elastaseHomo sapiens (human)
biosynthetic process of antibacterial peptides active against Gram-negative bacteriaNeutrophil elastaseHomo sapiens (human)
proteolysisNeutrophil elastaseHomo sapiens (human)
intracellular calcium ion homeostasisNeutrophil elastaseHomo sapiens (human)
response to UVNeutrophil elastaseHomo sapiens (human)
extracellular matrix disassemblyNeutrophil elastaseHomo sapiens (human)
protein catabolic processNeutrophil elastaseHomo sapiens (human)
response to lipopolysaccharideNeutrophil elastaseHomo sapiens (human)
negative regulation of chemokine productionNeutrophil elastaseHomo sapiens (human)
negative regulation of interleukin-8 productionNeutrophil elastaseHomo sapiens (human)
positive regulation of interleukin-8 productionNeutrophil elastaseHomo sapiens (human)
defense response to bacteriumNeutrophil elastaseHomo sapiens (human)
positive regulation of MAP kinase activityNeutrophil elastaseHomo sapiens (human)
positive regulation of smooth muscle cell proliferationNeutrophil elastaseHomo sapiens (human)
negative regulation of inflammatory responseNeutrophil elastaseHomo sapiens (human)
positive regulation of immune responseNeutrophil elastaseHomo sapiens (human)
negative regulation of chemotaxisNeutrophil elastaseHomo sapiens (human)
pyroptosisNeutrophil elastaseHomo sapiens (human)
neutrophil-mediated killing of gram-negative bacteriumNeutrophil elastaseHomo sapiens (human)
neutrophil-mediated killing of fungusNeutrophil elastaseHomo sapiens (human)
positive regulation of leukocyte tethering or rollingNeutrophil elastaseHomo sapiens (human)
phagocytosisNeutrophil elastaseHomo sapiens (human)
acute inflammatory response to antigenic stimulusNeutrophil elastaseHomo sapiens (human)
negative regulation of endothelial cell proliferationPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukocyte chemotaxis involved in inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukocyte migration involved in inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukotriene production involved in inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukotriene metabolic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
humoral immune responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of angiogenesisPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukotriene biosynthetic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
lipoxygenase pathwayPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
positive regulation of bone mineralizationPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
dendritic cell migrationPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
glucose homeostasisPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
long-chain fatty acid biosynthetic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of fat cell differentiationPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of insulin secretionPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of vascular wound healingPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of wound healingPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of inflammatory response to woundingPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of cytokine production involved in inflammatory responsePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of cellular response to oxidative stressPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
leukotriene A4 biosynthetic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
regulation of reactive oxygen species biosynthetic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of response to endoplasmic reticulum stressPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
negative regulation of sprouting angiogenesisPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
positive regulation of leukocyte adhesion to arterial endothelial cellPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
lipoxin biosynthetic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
arachidonic acid metabolic processPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
lipid oxidationPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
acetylcholine catabolic process in synaptic cleftAcetylcholinesteraseHomo sapiens (human)
regulation of receptor recyclingAcetylcholinesteraseHomo sapiens (human)
osteoblast developmentAcetylcholinesteraseHomo sapiens (human)
acetylcholine catabolic processAcetylcholinesteraseHomo sapiens (human)
cell adhesionAcetylcholinesteraseHomo sapiens (human)
nervous system developmentAcetylcholinesteraseHomo sapiens (human)
synapse assemblyAcetylcholinesteraseHomo sapiens (human)
receptor internalizationAcetylcholinesteraseHomo sapiens (human)
negative regulation of synaptic transmission, cholinergicAcetylcholinesteraseHomo sapiens (human)
amyloid precursor protein metabolic processAcetylcholinesteraseHomo sapiens (human)
positive regulation of protein secretionAcetylcholinesteraseHomo sapiens (human)
retina development in camera-type eyeAcetylcholinesteraseHomo sapiens (human)
acetylcholine receptor signaling pathwayAcetylcholinesteraseHomo sapiens (human)
positive regulation of cold-induced thermogenesisAcetylcholinesteraseHomo sapiens (human)
prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
response to oxidative stressProstaglandin G/H synthase 2Homo sapiens (human)
embryo implantationProstaglandin G/H synthase 2Homo sapiens (human)
learningProstaglandin G/H synthase 2Homo sapiens (human)
memoryProstaglandin G/H synthase 2Homo sapiens (human)
regulation of blood pressureProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell population proliferationProstaglandin G/H synthase 2Homo sapiens (human)
response to xenobiotic stimulusProstaglandin G/H synthase 2Homo sapiens (human)
response to nematodeProstaglandin G/H synthase 2Homo sapiens (human)
response to fructoseProstaglandin G/H synthase 2Homo sapiens (human)
response to manganese ionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vascular endothelial growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cyclooxygenase pathwayProstaglandin G/H synthase 2Homo sapiens (human)
bone mineralizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fever generationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic plasticityProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of synaptic transmission, dopaminergicProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin secretionProstaglandin G/H synthase 2Homo sapiens (human)
response to estradiolProstaglandin G/H synthase 2Homo sapiens (human)
response to lipopolysaccharideProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylationProstaglandin G/H synthase 2Homo sapiens (human)
response to vitamin DProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to heatProstaglandin G/H synthase 2Homo sapiens (human)
response to tumor necrosis factorProstaglandin G/H synthase 2Homo sapiens (human)
maintenance of blood-brain barrierProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of protein import into nucleusProstaglandin G/H synthase 2Homo sapiens (human)
hair cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of apoptotic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of nitric oxide biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vasoconstrictionProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
decidualizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle cell proliferationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of inflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
response to glucocorticoidProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of calcium ion transportProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergicProstaglandin G/H synthase 2Homo sapiens (human)
response to fatty acidProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to mechanical stimulusProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to lead ionProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to ATPProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to hypoxiaProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to non-ionic osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to fluid shear stressProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of transforming growth factor beta productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fibroblast growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of platelet-derived growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cellular oxidant detoxificationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of neuroinflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to homocysteineProstaglandin G/H synthase 2Homo sapiens (human)
response to angiotensinProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (27)

Processvia Protein(s)Taxonomy
protease bindingNeutrophil elastaseHomo sapiens (human)
transcription corepressor activityNeutrophil elastaseHomo sapiens (human)
endopeptidase activityNeutrophil elastaseHomo sapiens (human)
serine-type endopeptidase activityNeutrophil elastaseHomo sapiens (human)
protein bindingNeutrophil elastaseHomo sapiens (human)
heparin bindingNeutrophil elastaseHomo sapiens (human)
peptidase activityNeutrophil elastaseHomo sapiens (human)
cytokine bindingNeutrophil elastaseHomo sapiens (human)
arachidonate 5-lipoxygenase activityPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
arachidonate 12(S)-lipoxygenase activityPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
iron ion bindingPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
protein bindingPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
hydrolase activityPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
arachidonate 8(S)-lipoxygenase activityPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
amyloid-beta bindingAcetylcholinesteraseHomo sapiens (human)
acetylcholinesterase activityAcetylcholinesteraseHomo sapiens (human)
cholinesterase activityAcetylcholinesteraseHomo sapiens (human)
protein bindingAcetylcholinesteraseHomo sapiens (human)
collagen bindingAcetylcholinesteraseHomo sapiens (human)
hydrolase activityAcetylcholinesteraseHomo sapiens (human)
serine hydrolase activityAcetylcholinesteraseHomo sapiens (human)
acetylcholine bindingAcetylcholinesteraseHomo sapiens (human)
protein homodimerization activityAcetylcholinesteraseHomo sapiens (human)
laminin bindingAcetylcholinesteraseHomo sapiens (human)
peroxidase activityProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin-endoperoxide synthase activityProstaglandin G/H synthase 2Homo sapiens (human)
protein bindingProstaglandin G/H synthase 2Homo sapiens (human)
enzyme bindingProstaglandin G/H synthase 2Homo sapiens (human)
heme bindingProstaglandin G/H synthase 2Homo sapiens (human)
protein homodimerization activityProstaglandin G/H synthase 2Homo sapiens (human)
metal ion bindingProstaglandin G/H synthase 2Homo sapiens (human)
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (37)

Processvia Protein(s)Taxonomy
extracellular regionNeutrophil elastaseHomo sapiens (human)
extracellular spaceNeutrophil elastaseHomo sapiens (human)
cytoplasmNeutrophil elastaseHomo sapiens (human)
cytosolNeutrophil elastaseHomo sapiens (human)
cell surfaceNeutrophil elastaseHomo sapiens (human)
secretory granuleNeutrophil elastaseHomo sapiens (human)
azurophil granule lumenNeutrophil elastaseHomo sapiens (human)
specific granule lumenNeutrophil elastaseHomo sapiens (human)
phagocytic vesicleNeutrophil elastaseHomo sapiens (human)
collagen-containing extracellular matrixNeutrophil elastaseHomo sapiens (human)
extracellular exosomeNeutrophil elastaseHomo sapiens (human)
transcription repressor complexNeutrophil elastaseHomo sapiens (human)
extracellular spaceNeutrophil elastaseHomo sapiens (human)
extracellular regionPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
extracellular spacePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nuclear envelopePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nuclear envelope lumenPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nucleoplasmPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
cytosolPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nuclear matrixPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nuclear membranePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
secretory granule lumenPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
perinuclear region of cytoplasmPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
ficolin-1-rich granule lumenPolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
nuclear envelopePolyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)
extracellular regionAcetylcholinesteraseHomo sapiens (human)
basement membraneAcetylcholinesteraseHomo sapiens (human)
extracellular spaceAcetylcholinesteraseHomo sapiens (human)
nucleusAcetylcholinesteraseHomo sapiens (human)
Golgi apparatusAcetylcholinesteraseHomo sapiens (human)
plasma membraneAcetylcholinesteraseHomo sapiens (human)
cell surfaceAcetylcholinesteraseHomo sapiens (human)
membraneAcetylcholinesteraseHomo sapiens (human)
neuromuscular junctionAcetylcholinesteraseHomo sapiens (human)
synaptic cleftAcetylcholinesteraseHomo sapiens (human)
synapseAcetylcholinesteraseHomo sapiens (human)
perinuclear region of cytoplasmAcetylcholinesteraseHomo sapiens (human)
side of membraneAcetylcholinesteraseHomo sapiens (human)
nuclear inner membraneProstaglandin G/H synthase 2Homo sapiens (human)
nuclear outer membraneProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulumProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum lumenProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum membraneProstaglandin G/H synthase 2Homo sapiens (human)
caveolaProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
protein-containing complexProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (73)

Assay IDTitleYearJournalArticle
AID280644Antiproliferative activity against drug-sensitive human A2780 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.
AID1424046Selectivity index, ratio of IC50 for ram seminal vesicle COX1 to IC50 for human recombinant COX22017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID750049Inhibition of SARS coronavirus papain-like protease (1541 to 1855 amino acids) expressed in Escherichia coli BL21 (DE3) using Z-RLRGG-AMC as substrate by fluorogenic assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa.
AID1424056Increase in COX2 protein expression in human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID654699Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1227989Antiinflammatory activity in differentiated human THP1 cells assessed as inhibition of LPS-induced TNFalpha mRNA expression at 2 uM after 4 hrs by RT-qPCR analysis2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID402311Cytotoxicity against human NCI-H187 cells2005Journal of natural products, Jun, Volume: 68, Issue:6
Constituents of the leaves of Macaranga tanarius.
AID767582Antioxidant activity assessed as hypochlorous acid scavenging activity by fluorescence assay2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID477847Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID1424460Growth inhibition of human A549 cells2017European journal of medicinal chemistry, Dec-15, Volume: 142From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
AID654839Mixed type inhibition of equine BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424054Inhibition of LPS-induced increase in CXCL1 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID477845Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID1424048Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition and measured after 10 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID402309Cytotoxicity against human KB cells2005Journal of natural products, Jun, Volume: 68, Issue:6
Constituents of the leaves of Macaranga tanarius.
AID378531Cytotoxicity against human A2780 cells2005Journal of natural products, Mar, Volume: 68, Issue:3
Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest.
AID385172Antibacterial activity against Listeria monocytogenes ATCC 7644 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID311087Cytotoxicity against rat WB344 cells at 5 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID654840Binding affinity to human erythrocyte AChE assessed as fluorescence quenching by microplate reader2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424044Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID767584Antioxidant activity assessed as hydrogen peroxide radical scavenging activity by chemiluminescence method2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID402313Antioxidant activity assessed as DPPH radical scavenging activity by TLC autographic assay2005Journal of natural products, Jun, Volume: 68, Issue:6
Constituents of the leaves of Macaranga tanarius.
AID385173Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1227992Antiinflammatory activity in differentiated human THP1 cells assessed as inhibition of LPS-induced ROS level at 2 uM pretreated for 1 hr measured after 24 hrs of LPS stimulation by fluorescence assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID1424047Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production at 20 uM pre-incubated for 10 mins before arachidonic acid addition and measured after 10 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1502927Inhibition of human neutrophil elastase using MeOSuc-AAPV-pNA as substrate measured after 30 mins by spectrometric method2017Journal of natural products, 10-27, Volume: 80, Issue:10
Potential Anti-inflammatory Effects of the Fruits of Paulownia tomentosa.
AID654700Mixed type inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID654841Binding affinity to human erythrocyte AChE2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424058Increase in TX1B3 protein expression in human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID402310Cytotoxicity against human BC cells2005Journal of natural products, Jun, Volume: 68, Issue:6
Constituents of the leaves of Macaranga tanarius.
AID311090Cytotoxicity against rat WB344 cells after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID311088Cytotoxicity against rat WB344 cells at 25 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID385177Antibacterial activity against Salmonella enteritidis ATCC 13076 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424045Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation at 20 uM pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID385169Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID385171Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID402312Cytotoxicity against african green monkey Vero cells2005Journal of natural products, Jun, Volume: 68, Issue:6
Constituents of the leaves of Macaranga tanarius.
AID385170Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID767572Inhibition of NFkappaB in mouse J774A1 cells assessed as LPS-stimulated IkappaB-alpha degradation at 0.25 to 1.25 uM pretreated 30 mins before LPS challenge measured after 30 mins2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID767586Antioxidant activity assessed as NADH/phenazine methosulfate generated superoxide anion scavenging after 2 mins by NBT reduction assay2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID477850Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID385174Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID385340Antibacterial activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID750048Mixed-type of inhibition of SARS coronavirus papain-like protease (1541 to 1855 amino acids) expressed in Escherichia coli BL21 (DE3) using Z-RLRGG-AMC as substrate by Dixon plot analysis2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa.
AID1424042Increase in COX2 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID654843Reversible inhibition of human erythrocyte AChE using assessed as acetylthiocholine iodide hydrolysis by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424049Potency index, ratio of IC50 for zileuton to IC50 for test compound fior inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition and measured after 10 mins by ELIS2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID477849Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID477846Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID767581Induction of ROS production in mouse J774A1 cells at 0.25 to 1.25 uM after 30 mins by flow cytometry relative to control2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID654701Inhibition of equine BChE assessed as butyrylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424051Inhibition of LPS-induced increase in IL1 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1502928Noncompetitive inhibition of human neutrophil elastase using varying levels of MeOSuc-AAPV-pNA as substrate measured after 30 mins by double-reciprocal Lineweaver-Burk plot analysis2017Journal of natural products, 10-27, Volume: 80, Issue:10
Potential Anti-inflammatory Effects of the Fruits of Paulownia tomentosa.
AID1424043Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1227991Antiinflammatory activity in differentiated human THP1 cells assessed as inhibition of LPS-induced NFkappaB activation at 2 uM pretreated for 1 hr measured after 4 hrs of LPS stimulation by DAPI-staining based immunohistochemical analysis2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID1424057Increase in RNF207 protein expression in human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1227987Cytotoxicity against human THP1 cells at 2 uM after 24 hrs by WST assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID767578Effect on ROS production in LPS-stimulated mouse J774A1 cells at 0.25 to 1.25 uM after 30 mins by flow cytometry2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID385175Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424055Inhibition of LPS-induced decrease in VIP2 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID311089Cytotoxicity against rat WB344 cells at 100 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID767587Reduction of LPS-induced COX2 expression in mouse J774A1 cells at 1.25 uM pretreated 1 hr before LPS challenge measured after 24 hrs2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID1424052Inhibition of LPS-induced increase in CCL1 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID311086Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM by TEAC assay2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID477848Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID767576Induction of ROS production in LPS-stimulated mouse J774A1 cells at 1.25 uM after 24 hrs by flow cytometry relative to control2013Journal of natural products, Sep-27, Volume: 76, Issue:9
Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
AID1227986Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by WST assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID385176Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424053Inhibition of LPS-induced increase in CCL5 protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1227990Antiinflammatory activity in differentiated human THP1 cells assessed as inhibition of LPS-induced IkappaB degradation at 2 uM pretreated for 1 hr measured after 30 mins of LPS stimulation by Western blot analysis2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID654842Ratio of eriodictyol IC50 to compound IC50 for human erythrocyte AChE2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID1424050Inhibition of LPS-induced increase in TNFalpha protein expression in LPS-stimulated human THP1 cells at 2 uM by proteomic analysis relative to untreated control2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID477851Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (37.50)29.6817
2010's10 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.67 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
melatonin
[no description available]		3.2510acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0410aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.1510monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
pomiferin
pomiferin: structure in first source		2.0810isoflavanones
ag 1879
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor		3.2510aromatic amine;
monochlorobenzenes;
pyrazolopyrimidine		beta-adrenergic antagonist;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector
physostigmine
Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.		2.0710carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
phenylethyl alcohol
Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.. 2-phenylethanol : A primary alcohol that is ethanol substituted by a phenyl group at position 2.		2.0210benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
butylated hydroxytoluene
2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.		2.0210phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
diaziquone
diaziquone: RN given refers to parent cpd. diaziquone : A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.		2.05101,4-benzoquinones;
aziridines;
carbamate ester;
enamine		alkylating agent;
antineoplastic agent
zileuton
[no description available]		2.15101-benzothiophenes;
ureas		anti-asthmatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor;
leukotriene antagonist;
non-steroidal anti-inflammatory drug
hesperetin
[no description available]		2.47203'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite
osajin
osajin: from Maclura pomifera		2.0810isoflavanones
triptolide
[no description available]		3.2510diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.7730(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		2.0510taxifolinmetabolite
eriodictyol
eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.		2.49203'-hydroxyflavanones;
tetrahydroxyflavanone
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.2510resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.0210actinomycinmutagen
IPA-3
IPA-3 : An organic disulfide obtained by oxidative dimerisation of 1-sulfanylnaphthalen-2-ol.		3.2510naphthols;
organic disulfide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
glycosides
[no description available]		2.1510
vedelianin
vedelianin: Cytotoxic; from Macaranga tanarius; structure in first source. vedelianin : A stilbenoid derivative isolated from Macaranga alnifolia and Macaranga alnifolia and has been shown to exhibit cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
plant metabolite
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		3.2510caffeic acidgeroprotector;
mouse metabolite
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.2510aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone: structure given in first source; endogenous differentiation-inducing factor; induces stalk-cell differentiation in the cellular slime mold Dictyostelium discoideum		3.2510
quercetin
[no description available]		2.15107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.1510trihydroxyflavoneantineoplastic agent;
metabolite
luteolin
[no description available]		2.15103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
vomifoliol
blumenol A: a phytotoxin isolated from Oryza sativa Awaakamai; structure in first source. vomifoliol : A fenchane monoterpenoid that is 3,5,5-trimethylcyclohex-2-en-1-one substituted by a hydroxy and a (1E)-3-hydroxybut-1-en-1-yl group at position 4.. (6S,9R)-vomifoliol : A (6S)-vomifoliol with a R configuration for the hydroxy group at position 9.		2.0210(6S)-vomifoliolmetabolite;
phytotoxin
mycophenolate mofetil
mycophenolate mofetil : A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.		3.2510carboxylic ester;
ether;
gamma-lactone;
phenols;
tertiary amino compound		anticoronaviral agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
immunosuppressive agent;
prodrug
cucurbitacin i
cucurbitacin I: toxic constituent in edible gourd; see also records for cucurbitacins & specific cucurbitacins. cucurbitacin I : A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22.		3.2510cucurbitacin;
tertiary alpha-hydroxy ketone		antineoplastic agent;
plant metabolite
caffeic acid phenethyl ester
phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.		3.5620alkyl caffeate esteranti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent
muromonab-cd3
cudraflavone B: antiproliferative from Cudrania tricuspidata. cudraflavone B : An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.		2.0810extended flavonoid;
pyranochromane;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
artepillin c
artepillin C: RN refers to (E)-isomer		3.2510
olomoucine ii
olomoucine II: structure in first source		2.0510
mimulone
mimulone: structure in first source		3.6790
nymphaeol c
nymphaeol C: from the leaves of Macaranga tanarius; structure in first source. nymphaeol C : A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy group at positions 5, 7, 3' and 4', a geranyl group at position 2' and a prenyl group at position 6. Isolated from Macaranga tanarius and propolis collected in Okinawa, it exhibits radical scavenging activity.		3.87304'-hydroxyflavanones;
tetrahydroxyflavanone		metabolite;
radical scavenger
ym 155
sepantronium bromide : An organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis.		3.2510organic bromide saltantineoplastic agent;
apoptosis inducer;
survivin suppressant
nystatin a1
Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.		2.0410nystatins
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0210
schweinfurthin g
schweinfurthin G: structure in first source. schweinfurthin G : A stilbenoid that is the 3-deoxy derivative of vedelianin. Isolated from Macaranga alnifolia, it exhibits cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
metabolite
schweinfurthin f
schweinfurthin F: structure in first source. schweinfurthin F : A stilbenoid isolated from Macaranga alnifolia and has been shown to exhibit cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		metabolite
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity		3.2510
frax486
[no description available]		3.2510
frax597
FRAX597: structure in first source		3.2510
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		2.0210nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ag-879
AG-879: structure given in first source		3.2510
frondoside a
frondoside A: from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Ovary
[description not available]		02.0310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0310
Benign Neoplasms
[description not available]		03.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0610
Malignant Melanoma
[description not available]		02.0210
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.0210